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Sudathip Sae-tan

Sudathip Sae-tan

The Pennsylvania State University, USA

Title: Anti-diabetic Activities of Vitexin and Isovitexin from Mungbean Soup

Biography

Biography: Sudathip Sae-tan

Abstract

Diabetes is one of the worldwide non-communicable chronic diseases. Mungbean is one of plant legumes grown in Asia. It is rich with phytochemical compounds that are beneficial to the human health and also has the preventive effects against certain diseases. Vitexin and isovitexin are flavones found with high amount in mungbean. Both are known to have many biological activities including antioxidant, anti-proliferation, anti-inflammation and anti-diabetes. Mungbean soup is one of the popular healthy drinks. This study focuses on anti-diabetic effects of mungbean soup. Mungbean soup was standardized for concentrations of vitexin and isovitexin by high performance liquid chromatography before it was examined the anti-diabetic effects. The result showed that mungbean soup could inhibit alpha-amylase with IC50 0.1437 and 0.2826 mg/ml and inhibit alpha-glucosidase with IC50 0.0239 and 0.0469 mg/ml (vitexin and isovitexin, respectively). Mungbean soup could also inhibit the formation of advanced glycation end products (AGEs) with IC50 0.0128 and 0.0252 mg/ml (vitexin and isovitexin, respectively). Our study suggests that mungbean soup containing vitexin and isovitexin has anti-diabetic effects and these effects are due in part to inhibition of carbohydrate-metabolizing enzymes and AGEs formation.