Dina Keumala Sari
University of Sumatera Utara, Indonesia
Title: Vitamin D supplementation increased 25(OH)D serum levels but did not reach normal range in North Sumatera women with vitamin D receptor gene polymorphism
Biography
Biography: Dina Keumala Sari
Abstract
Background: A large proportion of women living in tropical regions experience Vitamin D deficiency especially in North Sumatera, Indonesia, and lifestyle being one of the predisposing factors. Other causes may be attributed to the presence of polymorphism in the Vitamin D receptor gene TaqI and BsmI.
Objective: To assess the effect of 1000 IU vitamin D supplementation on 25(OH)D serum and calcium levels in North Sumatera women with vitamin D re ceptor gene polymorphism (TaqI and BsmI).
Design: The study was a parallel clinical trial, thirtysix subjects with vitamin D receptor gene polymorphism (TaqI and BsmI) were selected using certain criterias. The subjects were devided into two groups using block randomization. Nineteen subjects in vitamin D group received 1000 IU vitamin D supplementation per day and dietary counseling (D), while seventeen subjects in counseling group received placebo and dietary counseling (C). Serum 25-hydroxyvitamin D and calcium levels were assessed on day 0 and 28. Before and after treatment, dietary intake were assessed with 2x24 hour recal methods.
Results: Nineteen subjects in D group and seventeen subjects in C group completed the study. There was no significant differences in baseline data both groups. After 28 days treatment, there was no significant differences in nutrients intake in two groups except vitamin D intake in D group. There was significant increase in 25(OH)D serum level in D group while no change was observed in the C group (p=0.04). Serum calcium concentration showed no significant change in both groups. There was significant differences between both group but all subjects did not reach normal value in 25(OH)D serum level (normal value >30 ng/mL).
Conclusions: The result shows that vitamin D deficiency can occur in women with Vitamin D receptor gene polymorphism even already supplemented with 1000 IU vitamin D.