Francois Andre Allaert
Cen Nutriment Dijon, France
Title: Chitosan reduces hypertensive toxicity of the NaCl: results of a randomised double blind cross over clinical trial
Biography
Biography: Francois Andre Allaert
Abstract
Study context:. Hypertensive patients have difficulties to reduce salt intake and one new strategy is not only to reduce the salt quantity but also its hypertensive toxicity.
Main objective: The main objective was to compare the decrease of the high blood pressure (HBP) parameter with Symbiosal (NaCl + Chitosan 3%) and with NaCl during the diet and lifestyle improvement period before an eventual antihypertensive treatment
Study design: Double blind, randomized, cross over, controlled clinical trial of Symbiosal (NaCl + Chitosan 3%) vs NaCl on two groups of 20 patients during two periods of 8 weeks. Inclusion criteria: Men and women older than 18 years presenting a mild hypertension defined by a SBP between 140-159 mmHg and a DBP between 90-99 mmHg g and having never been treated with an antihypertensive drug.
Results: 40 patients were included and the effect of Symbiosal appeared as soon as the first period of the cross over showing a decrease of the SBP from 149.2 ± 4.9mmHg to 136.1 ± 9.5 mmHg in patients for which Symbosial was available (decrease of 13.1 ± 10.8 mmHg) versus a decrease from 149.7 ± 4.6 mmHg to 142.9 ± 7.7mmHg in patients eating traditional NaCl (decrease of 6.8 ± 7.5mmHg) (p=0.0404). Similar results were observed with DBP with a decrease of 11.2 ± 7.4mmHg vs 7.0 ± 8.0mmHg (p=0.0560). HBP was controlled (SBP<= 140 and DBP<=90) in respectively 76.2% (16/21) vs 36.8% (7/19)% (p:0.0119). The cross over analysis on the two periods confirmed the results. The salt intake was relatively moderate in both groups: 2.9 ± 1 g/d vs 3.0 ± 1.5 g/d ( p: 0.9412 NS).Conclusion. Switching traditional NaCl by Symbiosal significantly contributes to a better control of hypertension in association to the lifestyle and diet recommendations and may delay the prescription of antihypertensive drugs.