Biography:

Harmit Singh’s research is focused on the promotion of more acceptable natural food ingredients and bio-friendly food processing technologies such as membrane and enzyme technologies. His recent projects include purification and concentration of natural food colors using membrane technology and evaluation of antioxidant properties and stability of these colors during application. His research is also focused on application of enzymes as processing aid to affect protein solubilization, allergen degradation and other food industry processes.

Abstract:

Statement of Problem: Membrane technology has become a potential technique to remove unwanted molecules and concentrate the natural colors without thermal treatment. However, this technology needs to be investigated for the efficiency and changes in ACNs quality throughout the process. The Purpose of this was to purify and concentrate ACN extract from red cabbage using membrane filtration; and to compare the color intensity, aroma, the antioxidant capacity, phenolic content and chemical composition of the purified anthocyanins.

Methodology: ACNs were extracted from red cabbage by constant agitation using a 0.5% HCl solution. The extracted suspension was centrifuged and clarified using Microfiltration (MF) membrane to remove any unwanted particles. The resulting permeate with color was collected and concentrated using Nanofiltration (NF). The final permeate and retentate were analyzed for composition and other characteristics. Reverse Phase High Performance Liquid Chromatography (RP-HPLC), colorimeter, antioxidant capacity and total phenolic content were used to evaluate any changes.

Findings: There was a 42% decrease in total phenolic content from raw sample to concentrated sample, while the antioxidant capacity remained the same at 16 mg/L throughout the whole process. No change in RP-HPLC was observed throughout the purification process indicating the concentration process did not affect ACNs composition. The NF membrane proved to have a good anthocyanin retention since no anthocyanin content was found in the permeate. Interestingly, the undesirable aroma from red cabbage was less intense in the concentrated sample as compared to the raw sample and will need further study.

Biography:

Sevil Yücel has received the PhD at Istanbul Technical University, Department of Chemical Engineering in 1991. She began working at Yildiz Technical University, Department of Bioengineering in 2006 as Assist. Prof. and worked at the same department with the title of Assoc. Prof. between 2009-2014 years. She is still working at Yildiz Technical University, Department of Bioengineering as professor till 2014. Sevil Yücel has many research papers published in SCI indexed journals and by the international indexed journals, book chapters and international meetings

Abstract:

Mushrooms have long been part of the human nutrition. In recent years, mushrooms have attracted much research attention due to being important natural resources of bioactive compounds, antibacterial, antioxidant, and anticancer agents. Tricholoma terreum (Schaeff.) P.Kumm. is an edible mushroom growing in many districts of Europe; however, the fruiting bodies of this wild mushroom was suspected as toxic and should be consumed after cooked [1]. In the present study, T. terreum were collected from MuÄŸla, Turkey. The influence of baking on the fatty acid profile and antioxidant activity of the extracts of T. terreum obtained by traditional, Soxhlet and ultrasonic assisted extraction technique was investigated. The fatty acid profile and antioxidant properties based on free radical scavenging activity was studied using GC-MS and spectrophotometer, respectively. The fatty acid content and radical scavenning activity of mushroom extracts were varied by using on the bases of different solvent extractions and several extraction techniques. The linoleic and palmitic  acid found to be the main fatty acids in baked samples while linoleic, linolenic and oleic acid in unbaked ones. When mushroom was baked, palmitic acid and linoleic acid percentages of all extracts increased, whilst linolenic acid decreased. Among the all extracts, the water extract of unbaked and baked mushroom obtained by Soxhlet extraction was found to be the most active on DPPH^• assay. It was observed that the baked mushroom extracts exhibited less activity than those of raw extracts

Biography:

Monira Pervin has completed her PhD studies in Nutritional Biochemistry at Graduate School of Nutritional and Environmental Sciences, Department of Food and Nutritional Sciences, University of Shizuoka, Japan with thesis entitled: “Studies on biological effects of plant lectins on animal cells and tissues”.  At present, she is working as postdoctoral research assistant in Tea Science Center, Graduate School of Integrated Pharmaceutical and Nutritional Sciences, University of Shizuoka, Japan on prevention of brain aging by green tea catechin using human neuroblastoma SH-SY5Y cells and mouse brain tissues. Her work has been reported in fifteen published paper in peer-reviewed Journals

Abstract:

The consumption of green tea catechins (GTCs) suppresses age-related cognitive dysfunction in mice. GTCs are composed of several catechins, of which epigallocatechin gallate (EGCG) is the most abundant, followed by epigallocatechin (EGC). Orally ingested EGCG is hydrolyzed by intestinal biota to EGC and gallic acid (GA). To understand the mechanism of action of GTCs on the brain, their permeability of the blood brain barrier (BBB) as well as their effects on cognitive function in mice and on nerve cell proliferation in vitro were examined. The in vitro BBB permeability (%, in 30 min) of EGCG, EGC and GA was 2.8±0.1, 3.4±0.3 and 6.5±0.6, respectively. The permeability of EGCG into the BBB indicates that EGCG reached the brain parenchyma even at a very low concentration. The learning ability of SAMP10 mice (a mouse model of brain senescence) that ingested EGCG (20 mg/kg) was significantly higher than of mice that ingested EGC or GA. However, combined ingestion of EGC and GA showed a significant improvement comparable to EGCG. SH-SY5Y cell growth was significantly enhanced by 0.05 µM EGCG, but this effect was reduced at higher concentrations. Co-administration of EGC and GA increased neurite length more than EGC or GA alone. These results suggested that cognitive dysfunction in mice is suppressed after ingesting GTCs when a low concentration of EGCG is incorporated into the brain parenchyma via the BBB. Furthermore, the additive effect of EGC and GA suggests that EGCG sustains a preventive effect after the hydrolysis to EGC and GA.

Biography:

I have been working at Osaka Municipal Technical Research Institute since graduating from KONAN University in Kobe, Japan, and have been engaged in research into microbial enzymes, such as glycosidases, glycosyl transferases, oxidases. I received a doctoral degree  on “Levan degrading enzymes”. I have also been interested in enzymatic and microbioal oxidation of saccharides. Productions of Lactobionic acid, D-glucuronic acid and D-glucaric acid are good  examples for effective conversion of aldose to aldonic acid, uronic acid and aldaric acid.

Abstract:

Objective:  Concerned about utilization of lactose and development of high-soluble calcium supplement, with an interest on biological oxidation of oligosaccharide, we examined microbial and enzymatic oxidation of lactose and aimed to establish  effective production systems of calcium lactobionate. Lactobionate, b-1,4-D-galactosyl-D-gluconate, is an oxidized product of lactose. It has been reported to have mineral-absorption-promoting effects, Biffidobacterium-growing activity, moisturizing effect, and high solubility in water. Despite its useful properties, lactobionate has been supplied only in a small scale by chemical oxidation because there is no easy and efficient way to produce it.

Results:  As for fermentation, we isolated a mutant strain of Burkholderia cepacia which has no b-galactosidase activity to avoid hydrolysis of lactose and has sugar-tolerance to react with concentrated lactose. After 4-day cultivation, lactose was completely disappeared and the equivalent molarity of calcium lactobionate was accumulated. In the case of 10-day-fed-batch culture, the final concentration of the product reached 400 g/L in 100% yield. The product was purified from culture supernatant by ethanol precipitation.

 As for microbial conversion, cells were incubated with 100 to 200 g/L of lactose and half mole equivalent calcium carbonate to lactose. The oxidation activity of the cells was defined as the amount of cells which produced 1 mmol of D-gluconate per minute from 0.1M D-glucose under the assay conditions. When 2 U/mL of cells were incubated with 100 , 150 and 200 g/Lof lactose, it took 18, 27 and 48 h for 100% conversion. Reuse of resting cells was available for repeated conversions. Cells of Gluconobacter sp.were also used for microbial conversion. As for enzymatic conversion, we isolated a strain of Paraconiothyrium sp. which secreted a stable oxidase in culture. These biological conversion systems of lactose were effective to produce calcium lactobionate with high yield, no by-product, easy purification, and easy operation in one-pot synthesis.

Biography:

Dina Keumala Sari has her expertise in vitamin D and polymorphism vitamin D receptor gene. Her interest in vitamin D creates a theory about microevolution in North Sumatera women in Indonesia

Abstract:

Background: A large proportion of women living in tropical regions experience Vitamin D deficiency especially in North Sumatera, Indonesia, and lifestyle being one of the predisposing factors. Other causes may be attributed to the presence of polymorphism in the Vitamin D receptor gene TaqI and BsmI.

Objective: To assess the effect of 1000 IU vitamin D supplementation on 25(OH)D serum and calcium levels in North Sumatera women with vitamin D re ceptor gene polymorphism (TaqI and BsmI).

Design: The study was a parallel clinical trial, thirtysix subjects with vitamin D receptor gene polymorphism (TaqI and BsmI) were selected using certain criterias. The subjects were devided into two groups using block randomization. Nineteen subjects in vitamin D group received 1000 IU vitamin D supplementation per day and dietary counseling (D), while seventeen subjects in counseling group received placebo and dietary counseling (C). Serum 25-hydroxyvitamin D and calcium levels were assessed on day 0 and 28. Before and after treatment, dietary intake were assessed with 2x24 hour recal methods.

Results: Nineteen subjects in D group and seventeen subjects in C group completed the study. There was no significant differences in baseline data both groups. After 28 days treatment, there was no significant differences in nutrients intake in two groups except vitamin D intake in D group. There was significant increase in 25(OH)D serum level in D group while no change was observed in the C group (p=0.04). Serum calcium concentration showed no significant change in both groups. There was significant differences between both group but all subjects did not reach normal value in 25(OH)D serum level (normal value >30 ng/mL).

Conclusions: The result shows that vitamin D deficiency can occur in women with Vitamin D receptor gene polymorphism even already supplemented with 1000 IU vitamin D.

Biography:

Alison Burton-Shepherd is a Registered Nutritionist (Scientist) and Senior Lecturer in Adult Nursing at De Montfort University Leicester UK. She is a part time Advanced Nurse Practitioner and Non Medical Prescriber. Recently she became an Inspector for the Care Quality Commission inspecting primary medical services to ensure that high standards of clinical care are being maintained. She is proud to be a Queens Nurse a title given to nurses who have achieved and continue to strive for excellence.

Abstract:

Chemo-radiotherapy (CRT) causes or exacerbates symptoms, such as alteration or loss of taste, mucositis, xerostomia, fatigue, nausea and vomiting, with consequent worsening of malnutrition. It is well known that radiotherapy is invariably associated with mucositis, xerostomia, dysphagia, haematological toxicities and other acute side effects, whose incidence increases when chemotherapy is also administered, and that oral mucositis incidence leads to higher unplanned breaks and delays in radiotherapy administration. In addition, in many patients such toxicities may be very severe and even life threatening and may lead to treatment interruptions that are invariably associated with poorer outcome. 

This presentation will review best practice in the nutritional management of patients undergoing chemotherapy and radiotherapy

Biography:

Iris Shai is a professor of Nutrition and Epidemiology at BGU and a visiting Scientist at Harvard School of Public Health in the field of nutrition and chronic diseases. Her focuses are long-term, compressive dietary randomized controlled trials (RCTs), performed in standards of drugs trials, and long-term cohorts. Following her fellowship in Harvard School of Public Health, she performed the 2-year Dietary Intervention Randomized Controlled Trial (DIRECT) and 4-year follow-up, comparing the effects of low-fat, Mediterranean and low-carb diets on cardiometabolic risk and plaque regression. In her next RCT she addressed the 2-year effect of moderate alcohol in type 2 diabetes and her current whole-body MRI RCT focus on dynamic of  human specific fat depots and fuel metabolism across dietary strategies

Abstract:

BACKGROUND: It remains unclear whether specific lifestyle strategies can differentially mobilize fat depots/ectopic-fat-deposits.                                                                                                        

METHODS: During an 18-month trial in an isolated workplace with monitored, provided lunch, we randomly assigned participants with abdominal obesity/dyslipidemia to iso-caloric low-fat(LF) or low-carbohydrate/Mediterranean(LC/MED) diets. After 6 months, we re-randomized half of each arm to moderately-intense physical-activity (PA⁺;80%-aerobic; free gym membership). We performed whole-body magnetic-resonance-imaging (3-Tesla-MRI) at 0,6,18 months

RESULTS: Of 278 randomized participants [age=48yr;88% men; body-mass-index=30.8kg/m²) 86.3% completed the trial. While the caloric deficit was similar, the LF group preferentially decreased saturated/unsaturated fats (p<0.001), and the LC/MED decreased carbohydrates (p<0.001) and trans-fat intake (p=0.029 vs. other diet). The PA⁺ group increased their MET/wk (p=0.009 vs. PA^-). Fat depots/deposits were significantly reduced to different degrees [Hepatic:(-32%);deep-subcutaneous-adipose-tissue(SAT):(-29%);visceral-adipose-tissue(VAT):(-25%);superficial-SAT:(-19%) and intra-pericardial:(-14%(-25mL))], with lesser changes of renal:(-9%);intermuscular:(-2%) and pancreatic-fat:(-1%). Although weight loss was comparable, LC/MED^PA+ favorably reduced waist-circumference (p<0.05), and induced -14% further loss of intra-pericaridal;p=0.003, -4% VAT;p=0.037 and -1.9% pancreatic-fat;p=0.007, compared to LF^PA- changes (reference-group; weight-loss-adjusted for all). LC/MED decreased hepatic fat beyond LF diet by -15%;p=0.044. Conversely, renal-sinus and femoral-intermuscular fat dynamics were similarly altered by lifestyle strategies. VAT and intrahepatic fat loss associated with an improved lipid profile, and deep-SAT loss with improved glycemic control.  

CONCLUSIONS: Human depots/ectopic-fat-deposits are substantially variable in their capacity to respond to different long-term moderate weight-loss strategies. LC/MED diet, particularly with PA, can favorably enhance fat mobilization in several depots. These findings may suggest defined lifestyle protocols for targeting specific fat storage sites.

Biography:

Yuanlong Pan completed his BVM from Gansu Agricultural University, P.R. China.  Dr. Pan received his PhD in Animal Nutrition from Virginia Tech, USA and PhD in Human Nutrition from UNC-Greensboro, USA. Dr. Pan conducted research in the area of menopause and cognition at Wake Forest University School of Medicine from 1996 to 2000. In 2000, Dr. Pan joined Nestle Purina Research. He has published more than 18 papers, and obtained 78 patents. Dr. Pan won the Academy of Science-St Louis 2016 George Engelmann Interdisciplinary Award for his outstanding achievement in science through collaboration and become a Fellow of the Academy of Science- St Louis.

Abstract:

Aging affects all tissues and organs in humans and animals including dogs and cats. Some senior dogs and cats eventually develop cognitive impairment and dementia called cognitive dysfunction syndrome (CDS), a condition similar to Alzheimer’s disease in people.  Since CDS is not a curable condition, our non-invasive research has been focused on nutritional strategies that promote healthy brain aging in dogs and cats. We have developed two nutritional solutions to enhance cognitive functions in dogs and cats. The first solution is to address the reduced ability of aging brain cells to utilize glucose as energy by feeding medium chain triglycerides (MCTs), and our studies have confirmed that MCTs enhance cognition in aging dogs. The second nutritional solution is to minimize known risk factors associated with brain aging. Since there are multiple risk factors, we have developed a nutrient blend targeting those risk factors and confirmed that the nutrient blend significantly enhances cognitive functions in middle-aged and aging cats. In summary, our research demonstrates that optimal nutrition can enhance cognitive functions in healthy aging dogs and cats. What we have developed for pets will help facilitate the development of similar nutritional solutions for people.    

Biography:

Prior to joining Duke University, Chow was the Director of TCOG (Taiwan Cooperative Oncology Group) Statistical Center and the Executive Director of National Clinical Trial Network Coordination Center. Prior to that, Chow also held various positions in the pharmaceutical industry such as Vice President, Biostatistics, Data Management, and Medical Writing at Millennium Pharmaceuticals, Inc., Cambridge, MA; Executive Director, Statistics and Clinical Programming at Covance, Inc., Director and Department Head at Bristol-Myers Squibb Company, Plansboro, NJ; Senior Statistician and Research Statistician at Parke-Davis Pharmaceutical Division, Warner-Lambert Company, Ann Arbor, MI and Wyeth-Ayerst Laboratories, Rouses Point, NY. Through these positions, Chow provided technical supervision and guidance to project teams on statistical issues and presentations before partners, regulatory agencies or scientific bodies, defending the appropriateness of statistical methods used in clinical trial design or data analyses or the validity of reported statistical inferences. Chow identified the best statistical and data management practices, organizes and leads working parties for development of statistical design, analyses and presentation applications, and participated on Data Safety Monitoring Boards in clinical research and development. Chow's professional activities include playing key roles in many professional organizations such as officer, Board of Directors member, Advisory Committee member, and Executive Committee member. He has served as Program-chair, session-chair moderator, panelist and instructor faculty at many professional conferences, symposia, workshops, tutorials and short courses. He is the Editor-in-Chief of the Journal of Biopharmaceutical Statistics. Chow is also the Editor-in-Chief of the Biostatistics Book Series at Chapman and Hall/CRC Press of Taylor & Francis Group. He was elected Fellow of the American Statistical Association in 1995 and an elected member of the ISI (International Statistical Institute) in 1999. He was the recipient of the DIA Outstanding Service Award (1996), ICSA Extraordinary Achievement Award (1996), and Chapter Service Recognition Award of the American Statistical Association (1998). Chow was appointed as Scientific Advisor to the Department of Health, Taiwan in 1999-2001 and 2006-date. Chow was President of the International Chinese Statistical Association, Chair of the Advisory Committee on Chinese Pharmaceutical Affairs, and a member of the Advisory Committee on Statistics of the DIA.

Abstract:

Human studies are essential to obtain evidence of beneficial effects of nutritional interventions on health. Clinical nutritional development plans include a range from small pilot trials to well-designed confirmatory studies, following good clinical practices.

Nutrition interventions are generally safe compared to pharmaceutical compounds. Regulatory guidance limits the benefits of nutrition to the maintenance of normal function or the reduction of accepted risk factors. Therefore, nutritional trials do not necessarily follow the same development process as pharmaceutical products. The objectives focus more on maintaining health and preventing risk factors for disease rather than showing efficacy in disease conditions. Clinical trials in the nutritional field have specific challenges to overcome in terms of population, intervention, design and methodology.  Additional challenges are the lack of learning phases, small beneficial effects, high heterogeneity of the responses and difficulties in finding appropriate endpoints.

In recent years, the use of adaptive design methods in clinical trials has received much attention due to its flexibility and efficiency in clinical development. In practice, adaptive design may provide the opportunity to modify certain aspects of the trial design whilst the study is still ongoing, without violating the quality and the integrity of the data. However, introducing more flexibility may come with many difficulties: major adaptations of on-going trials may result in designs unable to address the original scientific/medical questions. In addition, fundamental differences between pharmaceutical and nutritional research potentially trigger limitations but also opportunities for the application of such innovative design.

The aim of this work is to highlight specificities and challenges in nutritional clinical trials, review the concepts of adaptive design and then address the advantages, limitations, and feasibility of commonly considered adaptive designs. Statistical, clinical, operational and regulatory aspects of implementing adaptive designs will be discussed. 

Biography:

Hamish Love is a researcher and PhD candidate at the University of New England in NSW, Australia. After completing his degree in Psychology with Honours at CSU he found his interest in psychology further honed to the intersection of nutrition/diet and psychology and has been researching and studying since. His current focus is on the implementation of healthier dietary practice through improved understanding of self-control

Abstract:

Statement of the Problem: Numerous health problems and cause of death have been attributed to dietary factors. However, further nutritional education alone is insufficient, as APA surveys have shown that although American participant’s most common goal was to improve their diet for better health, 94% of respondents were unable to do so and cited insufficient self-control as the main barrier to success. However, as yet there are no validated models of the relationships between self-control and dietary outcomes or moderating psychological constructs. Further, scales do not yet exist to measure these constructs to measure potential targets for clinical intervention or future research.

Aims: The current study is validating new scales for measurement of psychological-nutritional constructs in self-control for dietary satisfaction.

Methodology & Theoretical Orientation: 3 new scales are under development and validation using factor analysis and convergent/divergent validity with existing scales. Based on previous models of self-control, a new model of self-control for satisfaction with dietary behavior will be tested.

Findings: The scales to be created for model testing are currently being validated, with research scheduled to be completed by March 2017. Conclusion & Significance: The creation of the scales displayed in Figure 1, a proposed model of self-control for satisfaction with dietary behavior, will contribute improved understanding of how self-control and related constructs interact with dietary goals to predict dietary outcomes for better health.

Biography:

Daniel is the Marketing & Communications Manager at Biopolis, a Spanish based biotech company producer of probiotics. He has expertise within the probiotics and food supplement industry by designing and developing new product ideas, communicating them (EFSA and FDA related issues) and giving marketing and promotion support to Biopolis’ clients and partners. He has previously worked in Coca-Cola and Millward Brown (both in Germany) and in Natraceutical in Spain. He holds an MSc in Food Economics & Marketing (University of Reading) and BSc in International Marketing & Communications (Hochschule Bremen and University of Valencia).

Abstract:

It is undeniable the fact that the probiotic market is suffering a transition where new trends are coming across. In addition to this, regulation (by means of EFSA in Europe) is extremely relevant. New trends and Health Claim Regulations entail new challenges and impact on innovation.

Furthermore, the industry is moving at a fast-growing pace so that products containing probiotics are attractive to both food and pharma companies.

New indications from different nature -the so called third generation claims- appear more and more as hot topics/niches (atopic dermatitis, psoriasis, stroke, sport nutrition, gut-brain axis), abandoning soft communications such as digestive health or immune system support.

In this sense, new and interesting final product ideas are being developed within the industry, where probiotic producers should acquire a relevant role, going together with pharma and food industry based companies as well as contract manufacturers in order to create outstanding synergies and fulfill new market needs.

Biography:

Zou Yuxiao has her expertise in Food Chemistry and Nutrition. Her research program addresses all aspects of sericulture resources and Characteristic Lingnan fruits/vegetables nutrition, bioactive substances and the related functional evaluation since 1998. She has hosted more than 20 items of national projects, including the National Natural Science Foundation of China, National Science and Technology Support Program and National Public Welfare Industry Science and Technology Program.   Since 2005, she won 8 prizes in provincial and ministerial level, including 3 first prizes (rank 3, 5, 8) 3 second prizes (rank 7, 10, 13) and 2 third prizes (rank 7, 9). She was authorized 24 pieces of invention patent, edited 5 books, published 65 articles and involved in the establishing of 4 items of enterprise product standard. During June 2010 to May 2011, she was in the Tufts University for further study with the funding from China Scholarship Council.

Abstract:

Silkworm pupae are good resources of edible oil that is especially rich in unsaturated fatty acids and considered an excellent dietary supplement for hyperlipidemia. In order to investigate the effects of silkworm pupae oil (SPO) on the lipid profile and oxidative stress, dyslipidemic-diabetic Wistar rats (n = 50) were divided into five diet groups of 10: normal control (C); high-fat diet control group (HF); and three other groups fed a high-fat diet with SPO supplementation (1, 2, or 4 mL•kg-1•d-1) orally. Groups fed with SPO had significantly lower concentrations of serum total cholesterol (TC) (P<0.05) and low-density lipoprotein cholesterol (LDL-C) (P<0.05) compared with the HF group. In regard to antioxidant parameters, except for levels of glutathione peroxidase (GSH-Px) in the liver, 2 and 4 mL•kg-1•d-1 of SPO supplementation leaded to higher total antioxidant capacity (T-AOC) (P<0.05), superoxide dismutase (SOD) (P<0.05) and GSH-Px levels (P<0.05) and lower malondialdehyde (MDA) levels (P<0.05) both in serum and liver versus the HF group. The study indicated that supplementation with SPO can improve lipid profiles and alleviate oxidative stress in dyslipidemic-diabetic rats induced by high-fat-diet, which showed great potential in ameliorating disorders of glucose and lipid metabolism.

Biography:

She studied nutrition at the Faculty of Medicine of Autonomous University of Yucatan where she now is teaching. Maria Luisa holds a master’s degree in Epidemiology from the National Institute of Public Health of Mexico, and she hold a PhD at Loughborough University. She is interested in the study of human growth, development, obesity, and body composition. During the last six years, she took part in a radio program on nutrition and health in Radio Universidad, in Merida. She has offered clinic consultations on obesity and eating disorders. She holds a Certificated like CONCER since 2016 and CONCAPREN since 2008 from Mexico. Also, holds a SNI level 1. At present, she works as teacher in the degree in nutrition at the Faculty of Medicine of UADY and researcher too. She is researcher supports in projects of the Cinvestav. She is also a teacher of Mexican dance and loves eating chocolates

Abstract:

Mexico has a high prevalence of stunting in children and adolescents, due to poor nutrition. Paradoxically, too many Mexican children and adolescents are currently overweight or obese (OW/OB). The dual-burden of stunting (low height for age) and OW/OB are nutritional conditions that increase the risk of developing chronic degenerative diseases in adulthood. The persistence of high levels of stunting in southern regions of Mexico, such as Yucatan, may be due to diet changes (nutrition transition) that Yucatecan population has experienced in recent years. Vitamins, such as folic acid (FA) and VB12 are micronutrients necessary for normal metabolism and growth. The relationships between the intake of these micronutrients and growth rate were identified. The impact of micronutrient consumption on body composition was also investigated. The sample population comprised 273 adolescents (152 females) aged 10-18 years, from Merida, Mexico. Dietary information was obtained using a food frequency questionnaire (FFQ) covering 106 local foods. Anthropometric and body composition measurements were taken, and socioeconomic data were gathered. Data were collected between September 2011 and July 2012. Over 50% of participants had inadequate consumption of both vitamins: 64% had inadequate intake of FA and 69% of VB12. Almost half (46.9%) were either short or stunted, and 33% were at risk of OW/OB. A higher risk of presenting OW/OB was found for participants with FA intake less than the RDI of 400 μg/day and for those with VB12 intake less than the RDI of 2.4 μg/day. No relationship was found between body fat percentage and the consumption of FA or VB12

Biography:

She studied nutrition at the University of Veracruz, Reyna holds a postgraduate in Teaching Specialization and Master in Higher Education in the Autonomous University of Yucatan in Merida and she holds a science doctorate in Physical Activity and Sport at the University of León getting Cum Laude. Holds a Teacher certification by the Company CONOCER since 2010. Works experiences were in Mexican Social Security Institute (IMSS) in the hospital area: 1984-1997 and Medical Network in the clinic consultations: 1997-2000. At present, she works in the Autonomous University of Yucatan, Faculty of Medicine, Bachelor of Nutrition Teaching: 1997 to date. She is interested in the study of Health self-care, eating disorder and cardiometabolic diseases

Abstract:

Objective: To determine the effects of a diet rich in lycopene, the practice of physical exercise or association between them on levels of blood lipids in adults with dyslipidemia.

Material and Methods: It is an experimental study with duration of 12 weeks. The diet was designed rich in lycopene (50mg / day), the standard diet and exercise program. Before and after the intervention lipid profile of the participants was determined. Involved people between 21 and 64 years old, randomly divided into 4 groups: two standard diet (one did exercise and one not), and the other two with diet rich in lycopene, one did exercise and one not. For each indicator behavior regarding their group arithmetic mean and standard deviation were used. Later ANOVA was used to demonstrate the significance and finally the post hoc Tukey test.

Results: 48 participants completed the study of which 35.4% (17) were male and 64.6% (31) female. The mean differences were significant post-pre cholesterol (p = 0.004) and LDL (p = 0.001). The mean difference between groups was significant for cholesterol between the standard diet with exercise and diet rich in lycopene with exercise and vice versa (p = 0.002). For the LDL was significant difference between the standard diet and exercise group with the other groups.

Conclusions: The lycopene-rich diet (50 mg / day) for 12 weeks significantly reduce LDL cholesterol levels and blood. Exercise training (4 days a week for 60 minutes) for 12 weeks significantly decreased blood levels of LDL when combined with the standard diet and cholesterol levels and LDL to be associated with diet rich in lycopene.

Biography:

Farag Ali Saleh has completed his PhD at the age of 32 years from Cairo University. He is the Prof of Food Science and Nutrition. He has published more than 26 papers in reputed journals and serving as an editorial board member of repute. He is member in many professional societies. He has attended more than 17 national and international conferences and scientific symposia

Abstract:

Recently, scientists interested in functional food, especially probiotic food which has many health benefits. Probiotic microorganisms expose to many risks during their presence in food products and after passing through gastrointestinal tract as well. Therefore, the a main goal of this study to try to keep probiotic bacteria alive in date products during storage period and after eating. Free and calcium alginate microencapsulated Bifidobacterium lactis Bb-12 were mixed with date paste and date syrup (Dibs) and exposed to simulated gastrointestinal conditions, to observe its effects on viability of  on B. lactis. The results showed that date paste and Dibs have a protective effect to the free bacteria and increased protection of encapsulated bacteria when compared to free bacteria without mixing with a date paste and Dibs. The viable counts of probiotic bacteria were numerated in date paste and Dibs during storage. At the end of the seventh week from storage period, the numbers of free B. lactis were reduced in both date paste and Dibs for up to 10⁶ cfu/g, while the numbers of encapsulated bacteria remained at 10⁷ cfu/g. The microencapsulated bacteria retained the numbers up to 10⁶ cfu/g until week ten. The changes in pH values, production of organic acid and color of date paste and Dibs were monitored during storage period. The sensory analysis of date products fortified with probiotic bacteria were evaluated. The results showed that the addition of both free and encapsulated probiotic bacteria did not show any significant effect on the sensory properties of date products. This study has  shown the microencapsulation protected Bifidobacterium lactis Bb-12 from the high sugars concentration of date products and simulated gastrointestinal conditions. Such of this product will provide an alternative probiotic food choice for consumers and could be particularly appealing to children.

Biography:

Niranjani Wickramasinghe is currently pursuing PhD in Public Health at Curtin University, Perth, Australia. She has completed her MSc from University of Peradeniya Sri Lanka and Bachelor of Science degree from The Open University of Sri Lanka. She has worked as a Clinical Dietitian and Obesity Management Dietitian in Sri Lanka and United Arab Emirates. She has submitted four articles from her PhD study for publication

Abstract:

Natto and tempeh are indigenous Asian soya fermented foods which were originated in Japan and Indonesia, but now also being consumed in all over the world. Importantly these soya based fermented foods are rich in phytoestrogens genistein and daidzein. Phytoestrogens are plant derived isoflavone compound which has similar structure and antagonize human estrogens. While some of previous research indicates that phytoestrogen may act as anti-carcinogenic agents and inhibits tumor growth in patients with breast cancers, some of the other scientific literature says that “they stimulate tumor growth and therefore leading to practical issue for safety of food with phytoestrogen such as soya. Also some of research data say that phytoestogens have increasing attention due to the beneficial effect on glucose, lipid metabolism (protection against cardiovascular diseases), osteoporosis and complications related to menopause. However these health benefits of soya and phytoestrogens are controversial issue as number of research findings has indicated inverse results as well. Moreover contrasting results have been recorded on its cancer protection ability (hormone dependent cancers such as breast and prostrate) and due to these negative findings health authorities of some countries have indicated maximum daily intake level for phytoestrogen. Therefore preparation of indigenous Asian fermented legume foods such as natto and tempeh using other comparable legume is an interesting alternative to avoid overdosing above mentioned compounds. The aim of this study was to determine the amount of genistein and daidzein content of lupin and fermented lupin (lupin natto and tempeh) and whether fermentation time affected the genistein and daidzein content of lupin. Lupin tempeh and lupin natto were prepared using either whole seed (WS) or de-hulled seed (DHS). Analysis for genistein and daidzein content was conducted using HPLC for time points zero, 12 h, 24 h, 36 h, 48 h and 72 h after fermentation. Repeated measures ANOVA with source of lupin as between-subject factor was independently run for lupin tempeh and lupin natto. Results revealed that the amount of genistien and daidzein significantly increased with time in both tempeh and natto. Both isoflavones peaked at 48 h in lupin tempeh and earlier at 36 h in lupin natto. WS tempeh and WS natto had significantly more genistein than WHS tempeh and WHS natto. Diadzein content of WHS tended to be higher than WS across both products. It is concluded that, lupin and fermented lupin have very low amount of genistein and daizein compared to soya bean. Therefore, it is safe to consume without risk of phytoeastrogen overdosing. Fermentation time increased the amount of genistein and daidzein content in both lupin tempeh and natto and the form of lupin raw material used affected the genistein level and to some extent the daidzein content of fermented products.

Biography:

Özlem TokuÅŸoÄŸlu has completed her PhD at Ege University Engineering Faculty, Dept. of Food Engineering in 2001. She is currently working as Associate Professor; Dr. Faculty Member in Celal Bayar University Engineering Faculty Department of Food Engineering. She performed a Visiting Scholar at the Food Science and Nutrition Department/University of Florida, Gainesville-Florida-USA during 1999-2000 and as Visiting Professor at the School of Food Science, Washington State University, Pullman, Washington,USA during April-May 2010. She has published many papers in peer reviewed journals and serving as an Editorial Board Member of selected journals. She published and scientifically edited two international books entitled “Fruit and Cereal Bioactives: Chemistry, Sources and Applications” and “Improved Food Quality with Novel Food Processing” by CRC Press, Taylor & Francis,USA Publisher, third book “Food By-Product Based Functional Food Powders” is in progress. She also published two national books entitled “Cacao and Chocolate Science and Technology” and “Special Fruit Olive: Chemistry, Quality and Technology”. She organized and/or administered as Conference Chair at many conferences and congresses in various parts of USA and Europe.

Abstract:

The purpose of the study is to determine the effect of preservation and different processing methods on shelf life and quality of oil obtained from less black table olives (natural black olives in brine and turning olives). For this purpose, samples of Gemlik variety olives were harvested from the orchards of Olive Research Institute located in Bornova and KemalpaÅŸa. Olives were processed by two kinds of methods including packaged with vacum and modified atmosphered (N₂ 60% and CO₂ 40%) packaging and applied gamma irradiation (0, 1, 3, 5 kGy), then olives were stored in the ambient conditions for 8 months. During fermentation, acidity and pH of black table olives produced through natural fermentation was changed in the standart duration. Slight increasings were observed in the acidity and pH values of vacuum and MAP packaging and gamma irradiated table olives at the end of the product storage. α-tocopherol, total chlorophyll, and total carotene values were decreased owing to the processing and storage along with radiation treatment and were found statistically significant (p<0.05). Tocopherol quantity decreased during storage (in turning olives from 142.13 to 23.25 mg/kg, naturally black olives in brine from 106.25 to 7.38 mg/kg). Total chlorophyll quantity showed a decrease during storage (in turning olives from 2.06 to 1.31 mg/kg, naturally black olives in brine from 1.24 to 0.65 mg/kg). Total carotenoid quantity diminished during storage (in turning olives from 2.57 to 2.38 mg/kg whereas naturally black olives in brine from 2.37 to 2.23 mg/kg). In this context, it is determined that the best preservation was performed by modified atmosphered packaging (MAP) technology

Biography:

Daniela Assimiti is a Romanian Clinical Biochemist and a Lecturer in   Biochemistry, Microbiology and Nutrition at “Dr. Luca” SDA Nursing College, Romania. Since   2005, she is teaching at St. John Mary International School and California Prep International School in Thailand.

Abstract:

It is interesting to know that even referring to such a kind of very minute effectors involved in the cellular processes, as the minerals and vitamins are, the mineral deficiencies can be still visibly expressed in the general state of health of an individual, as well as in the form of some specific external signs, particularly observed either by evaluating the skin (especially by performing a facial analysis for cell salts), or the fingernails. This study as a part of a more extended study which evaluated the level of stress and its interactions with the nutrition refers particularly to the context of observation of the aspect of the fingernails. The observations were made on 38 individuals (26 females and 12 males), residing in Thailand. The subjects were randomly chosen from different cultural and social backgrounds both Asian and Caucasian genders, age, blood type and type of diet. The results showed a clear prevalence of their deficiency which proves consistent with the previous statistics reported in the scientific literature for the Asian region. Among other kinds of mineral deficiencies, the zincone came to appear also with a certain frequency. Moreover, due to the lack of special preparation and laborious analytical procedure needed, this method shows to be very promising and extremely useful for mass screening, being easily applied as a method for the future prevention of mineral or vitamin deficiencies both in children and adults.

Biography:

Sudathip Sae-tan is interested in food and health. Currently she works at Department of Food Science and Technology, Faculty of Agro-Industry, Kasetsart University, Thailand. Her focus is on dietary food components to prevent non-communicable diseases. She has experiences in using chemical-based and cell-based assay including animal models to test the bioactivity. With all these assays, it allows her to find out the dietary components for disease prevention.

Abstract:

Diabetes is one of the worldwide non-communicable chronic diseases. Mungbean is one of plant legumes grown in Asia. It is rich with phytochemical compounds that are beneficial to the human health and also has the preventive effects against certain diseases. Vitexin and isovitexin are flavones found with high amount in mungbean. Both are known to have many biological activities including antioxidant, anti-proliferation, anti-inflammation and anti-diabetes. Mungbean soup is one of the popular healthy drinks. This study focuses on anti-diabetic effects of mungbean soup. Mungbean soup was standardized for concentrations of vitexin and isovitexin by high performance liquid chromatography before it was examined the anti-diabetic effects. The result showed that mungbean soup could inhibit alpha-amylase with IC₅₀ 0.1437 and 0.2826 mg/ml and inhibit alpha-glucosidase with IC₅₀ 0.0239 and 0.0469 mg/ml (vitexin and isovitexin, respectively). Mungbean soup could also inhibit the formation of advanced glycation end products (AGEs) with IC₅₀ 0.0128 and 0.0252 mg/ml (vitexin and isovitexin, respectively). Our study suggests that mungbean soup containing vitexin and isovitexin has anti-diabetic effects and these effects are due in part to inhibition of carbohydrate-metabolizing enzymes and AGEs formation.  

Biography:

Fatemeh Miremadi is an accredited practicing dietitian, specialized in hypercholesterlomia and food allergies, and working in different multidisciplinary medical centres across Melbourne, Australia since 2011. In 2013, she was awarded an Australian postgraduate award to commence her PhD at Victoria University, Melbourne. Australia.  Her project evaluates the combined effectiveness of probiotics, prebiotics and polyphenols in the synbiotic yogurt in modulating total cholesterol and LDL-C levels in mildly to moderately hypercholesterolemic population and its effectiveness in ameliorating cardiovascular disease risk factors in both women and men. She has already published 3 research papers leading journals and presenting her findings at national and international conferences

Abstract:

Statement of the Problem: The World Health Organization estimates 17.5 million deaths every year from cardiovascular diseases, particularly heart attacks and strokes. A substantial number of these fatalities can be attributed to lipid profile abnormalities, which triples the risk of heart attack in people with hypercholesterolemia, compared to those with normal blood lipid profiles. Various dietary approaches have been employed to alleviate hypercholesterolemia at the population level including the use of probiotics and prebiotics in development of functional foods. The purpose of this study is to evaluate the effects of a synbiotic yogurt, a novel product on lipid profile and blood pressure in mildly to moderately hypercholesterolemic and hypertensive subjects.

 Methodology & Theoretical Orientation: Synbiotic yogurt     contained probiotics L. rhamnusis and L. acidophilus, 2% prebiotic fructooligosaccharide enriched inulin (FEI) and 20% pomegranate juice concentrate (PJC) was used as dietary supplement. This product had 90% probiotics survivability, 72% total phenolic compounds and 68% antioxidant activity over a 4-week period of refrigerated storage. To assess its health benefits, an 8-week parallel, double-blinded, randomized trial was conducted with 48 male and female volunteers, aged 30-65 years, consuming a daily serve of 200g yogurt. Subjects were assigned to 3 groups: a control; group 2 consumed the synbiotic yogurt without PJC, and group 3 consumed the same synbiotic yogurt containing 20% PJC. Fasting blood samples, 3d dietary records, anthropometric measurements and BP were collected at baseline, end of 4 and 8 weeks.

Results: Consumption of the synbiotic yogurt containing PJC resulted in 6% decrease in total cholesterol and 8.3% decrease in low-density lipoprotein cholesterol (LDL-C) levels compared with the controls. Systolic blood pressure was reduced by 3.70 mmHg and diastolic blood pressure by 2.33 mm Hg. No significant changes from the baseline were observed in triglycerides and HDL-C levels. Total cholesterol: HDL-C ratio and LDL-C: HDL-C ratio as atherogenic indices significantly decreased in group 3 that consumed synbiotic yogurt containing PJC compared with the control group.

Conclusion: This study indicates the combined effectiveness of probiotics, prebiotics and polyphenols in ameliorating cardiovascular disease risk factors in both women and men

Biography:

Patarapan Odton has her Ph.D. in Research Methodology, Prince of Songkla University. She started working in health economics research at Ministry of Public Health since the year 2006. She’s moved to do research in economics of education during the past 5 years. She has expertise in health economics, statistical modelling, and GIS

Abstract:

Background: Breastfeeding is the gold standard when it comes to infant nutrition, and no artificially produced infant formula will ever be able to replace it. In the first years of life, breast milk protects infants from infections by passing on their mothers’ antibodies. In Thailand, there were many studies on prevalence and determinants of breastfeeding since National Breastfeeding Project began in 1989. Only few studies related to effects of breastfeeding on child’s nutritional status.

Objective of this study is to investigate impact of breastfeeding practices on nutritional status of children.

Methodology: The Thailand Multiple Indicator Cluster Survey (MICS3 and MICS4) are the main data source. For assessing the nutritional status of children, we use three anthropometric indices, weight-for-age, height-for-age, and weight-for-height. Regression models are performed to assess the effects of breastfeeding on child’s nutritional indices, including demographic and socio-economic factors.

Findings: Based on weight-for-age, height-forage, and weight-for-weight z-score, infant aged 0-5 months with exclusively and non-exclusively breastfed are not significantly different in all those three indices. During ages 6-11 months, infants who never been breastfed are moderately underweight and moderately stunted, much smaller and shorter than who ever been breastfed. There are no different in height-for-age when they get older, aged 24-59 months. Results from regression models indicate that infant with less than 6 months of breastfed are significantly higher in weight-for-age z-score than who never been breastfed. Children have been longer breastfed (24 months and over) are smaller than who never been breastfed. It’s clear that longer breastfed than 12 months can effects to lower weight-for-height.

Conclusion: Breastfeeding effect to nutrition indices when infant aged 6-11 months. Longer breastfed can effect to lower weight-for-age, height-for-age, and weight-for-height when they aged 12-47 months. At the fifth year of life, all children are in the standard weight and height.

Biography:

Özlem TokuÅŸoÄŸlu has completed her PhD at Ege University Engineering Faculty, Dept of Food Engineering in 2001. She is currently working as Associate Professor and faculty member in Celal Bayar University Engineering Faculty Department of Food Engineering. She was a Visiting Scholar at the Food Science and Nutrition Department/University of Florida, Gainesville-Florida-USA during 1999-2000 and a Visiting Professor at the School of Food Science, Washington State University, Pullman, Washington,USA during April-May 2010. She has published many papers in peer reviewed journals and serving as an Editorial Board Member of selected journals. She published and scientifically edited two international books entitled “Fruit and Cereal Bioactives: Chemistry, Sources and Applications” and “Improved Food Quality with Novel Food Processing” by CRC Press, Taylor & Francis,USA Publisher, third book “Food By-Product Based Functional Food Powders” is in progress. She also published two national books entitled “Cacao and Chocolate Science and Technology” and “Special Fruit Olive: Chemistry, Quality and Technology”. She organized and/or administered as Conference Chair at many conferences and congresses in various parts of USA and Europe.

Abstract:

The functional constituents of the foods or some functional foods must be standardized as nutraceutical products generated under good manufacturing practices (GMPs). These formulations should be applicated as food tablet forms. A nutraceutical is “any non-toxic food constituent that has scientifically proven health benefits, including disease treatment or prevention”. Oral utilization has been one of the most popular routes of drug delivery because of its ease of administration, patient compliance, least sterility constraints and flexible design of dosage forms. Food tablets are defined as unit dose, temper evident, solid preparations including one or more active ingredients or whole food powder. In applications, nutraceutical food tablets has been prepared by direct compression method. The powder blend has been thoroughly mixed with talc and magnesium stearate and compressed into a 300-400 mg tablet using single rotatory punching machine based on tablet processing strategy. The physiochemical properties including the bulk density (g/ml), tapped density (g/ml) as pre-compression parameter have been confirmed while thickness (mm), hardness (kg/cm²), % weight variation, % friability, % in- vitro drug release as post-compression parameters have been carried out. In our scientific research, black mulberry powder, aronia berry powder, mesir paste powder (containing 41 type spice mixture and majorly cinnamon), Turk powder (containing 15 type of endemic plant and spice mixture), hünnap fruit powder, sour cherry fruit, pomegranate peel powder applications performed, tablets were obtained and quality profiles were detemined. Phenolic compounds of above mentioned tablet forms were examined based on their active ingredients. It has been concluded that the nutraceutical tablets has been prepared by direct compression method and has given satisfactory and acceptable outputs. Additionaly, final products not included side effects, they were appropriate for consumer utilization and their cost were minimized. Conventional tablets of studied nutraceuticals showed immediate food and plant releasing owing to their direct compression. The formulation containing mesir powder could be more efficacious due to the major presence of cinnamaldehyde (as v/v) whereas black mulberry powder could be more beneficial as a nutraceutical food due to the presence of morusin and apigenin phenolic anticarcinogenics.

Biography:

Safrullah Amir is a student of Public Health Post-graduate Program at Universitas Gadjah Mada Indonesia. His research is focused on public health nutrition especially for maternal and child health. He worked as a Research Laboratory Assistant in Centre of Public Health Laboratory in Hasanuddin University before he took his Master’s degree

Abstract:

Statement of the problem: A high-risk pregnancy refers to anything that puts the mother, fetus, or neonate at increased risk for morbidity or mortality during pregnancy or childbirth. Indonesia still faces the increasing number of high risk pregnancy. Several risk factors for high risk pregnancy were present before pregnancy, include multiple pregnancies, maternal age under 16 or over 35 years, and interval between pregnancies less than one year. The purpose of this study is to determine the sociodemographic characteristic of pregnant women with high risk pregnancy in Indonesia.

Methodology & Theoretical Orientation: This study used Total Dietary Survey year 2014 data by National Institute of Health Research and Development (NIHRD), Ministry of Health Indonesia. The number of respondents was 644 from 162.044 individuals who have interviewed in this survey. Respondents were the women who have pregnancy during the time of data collection. High risk of pregnancy is according to maternal age (under 16 years and over 35 years) and interval between pregnancies.

Findings: Prevalence of pregnant women with high risk pregnancy in Indonesia was 20.2%. Based on regional, pregnant women who live in rural areas were higher than in urban area (56.2%). According to education, employment and income status, the pregnant women in Indonesia with lower education (66.2%), unemployed status (66.7%), and middle income (39%) have high risk of pregnancy.

Conclusion & Significance: To conclude, this study showed that majority of pregnant women with high risk pregnancy live in rural areas and have lower education, unemployed status, and middle income.

Biography:

Daniela Assimiti is a Romanian Clinical Biochemist and a Lecturer in   Biochemistry, Microbiology and Nutrition at “Dr. Luca” SDA Nursing College, Romania. Since   2005, she is teaching at St. John Mary International School and California Prep International School in Thailand.

Abstract:

Previous research over many decades determined the correlation between these three important components in their inter dependence and interaction. The mechanism that determine the inter dependence between blood type and diet are not secret anymore and in the long run the way each one of us manage to keep this sensible issue in a balance will influence the future state of well being and general health. The stress being one of the most critical problems of the modern times based on the incidence and also the negative influence it has on the health becomes the main object of discussion in the study realized on a representative group of population here in Thailand. The subjects were randomly chosen from different groups defined mainly based on culture and religion, economic background, age, blood type and type of diet. A number of 36 males and 57 females evaluated their individual stress level by using an adapted Holmes and Rahe scale. Further analysis determined and interpreted the correlations between the stress and their body type and diet. The results showed similar frequencies compared to data in the scientific literature in terms of blood type distribution, blood type stress link and blood type risk of certain diseases and diet stress relationship, which proves this approach as a very helpful tool suited for the management of the stress by using a specific and targeted type of diet.

Biography:

Gauree Konijeti is a gastroenterologist in La Jolla, California. She received her medical degree from Perelman School of Medicine at the University of Pennsylvania and has been in practice between 6-10 years

Abstract:

INTRODUCTION:

Recent data suggests dietary modification can improve clinical responses in inflammatory bowel disease (IBD). The goal of this study was to determine the tolerability and efficacy of an autoimmune protocol (AIP) diet in patients with Crohn's disease (CD) and ulcerative colitis (UC).

METHODS:

We enrolled 18 adult patients with IBD with mild-moderate disease activity (HBI ≥ 5 or partial Mayo score ≥ 3), and objective evidence of active disease (endoscopy within 7 months and/or elevated fecal calprotectin (FC) within 1 month). Three patients withdrew prior to study start due to inability to commit to dietary change. Participants transitioned to the AIP diet over 6 weeks (elimination of grains, legumes, nightshades, dairy, eggs, coffee, alcohol, nuts and seeds, and refined/processed sugars, oils, and food additives) and then maintained the diet for 5 additional weeks. Serial laboratories, fecal calprotectin, microbiome and transcriptome analyses were performed. Endoscopy, radiology, and/or biomarker assessment was performed at study completion to assess for mucosal healing.

RESULTS:

The final cohort included 9 patients with CD and 6 with UC. Mean IBD duration was 19 years (SD 14.6) and active biologic use in 7 patients. Nutrient repletion was initiated for deficiencies in vitamin D (n=3) and iron (n=6). From week 0 to 6, mean partial Mayo score improved from 5.8 (SD 1.2) to 1.2 (SD 2.0) (p<0.01) for UC, and mean HBI score improved from 7 (SD 1.5) to 3.6 (SD 2.1) (p<0.01). At baseline, CRP was normal (<10) in 66% (10/15). Among those with labs completed at baseline and week 6, mean CRP (n=11) improved from 8.3 to 7.0 (p=0.46), and mean FC (n=5) improved from 412 (range 80-1078) to 196 (range 0-758) (p=0.36). Among those with follow-up endoscopy at week 11 (n=7), improvements were noted in SES-CD (n=1), Rutgeerts score (n=1), and Mayo endoscopy subscore (n=4). No significant changes in lipid profile observed at week 6. One patient with ileal CD with stricture withdrew due to worsening symptoms.

DISCUSSION: 

Dietary elimination has the potential to improve symptoms and endoscopic inflammation in patients with inflammatory bowel disease. Larger randomized trials are needed to validate these findings

Biography:

Sima Hamadeh is an Assistant Professor and Program Coordinator of Nutrition & Dietetics Sciences at Haigazian University-Lebanon. Her interests lie in areas such as the dietary motivations and behaviors in communities; the evolution of nutrition; the epidemiology of obesity especially among youth; the health promotion and communication; and the nutrition policies. Her Master and Doctoral studies were awarded, the “Emerald Literati Network Awards for Excellence 2009” - as Highly Commended Award Winner and the “Prix d’Excellence Scientifique Franco-Libanais 2015” for the outstanding research project respectively. She has several publications in scientific refereed journals and books. She has also many oral communications on public health nutrition in international and national congresses. She works closely with different national ministries and organizations, and international institutions in projects, seminars, researches and community programs. She is also former member of several executive international Scientific Committees and Associations. 

Abstract:

Statement of the Problem: The current information environment around nutrition and physical activity is complex and often confusing to the public. Similarly, social determinants may mediate nutrition communication effects. The purpose of this study is to explore the most effective and trustful communication channels to the public about the evolving understanding of the relationship between nutrition, lifestyle and optimal health in Lebanon.

Methodology & Theoretical Orientation: A formative exploratory study was conducted to explore the most effective nutrition communication channels as perceived by a heterogeneous Lebanese sample (67 adults, 48 youth). An exhaustive integrated conceptual framework based on social marketing approach and mixing related theories and models was used in this study. Directed and semi-structured individual interviews and focus groups were conducted. Collected data have been submitted to a thematic qualitative analysis.

Findings: Knowledge alone cannot predict a healthy lifestyle especially among youth. A social marketing approach should be considered to succeed nutrition and physical activity messages. Success of various communication channels is subject to the influence of socio-demographic and cultural determinants, such as age, social class, social integration, geographical areas, and environmental support. Effective communication strategies should develop culturally relevant nutrition messages and delivery systems that take into account; the barriers to healthy lifestyles, the information sources, and the distinct population segments.

Conclusion & Significance: Comprehensive sociocultural-based nutrition communication strategies can help to successfully promote nutrition, physical activity and prevent diseases.

Biography:

Abstract:

The Philippines is one of the world’s emerging diabetes hotspots. According to the International Diabetes Federation, the Philippines ranked in the top 15 in the world for diabetes prevalence.  Philippines is home to more than 4 million people diagnosed with the disease – and a worryingly large unknown number who are unaware they have diabetes. How a diabetic takes care of his health everyday determines the quality of his existence. The major purpose of the study was to determine the self-management needs of the diabetics to come up with a sound development program that could be implemented by the extensionists in the university, the health-care providers and civic-society organizations.  The respondents included all the diabetic patients registered in the Diabetes clinic of a government hospital.  Data were gathered through interview schedule.  Other pertinent data were taken from the patients’ individual medical chart.  Descriptive and inferential statistics were utilized to interpret the data.  Results showed that the areas of concern needed by the diabetics are meal planning, self-monitoring of blood sugar, sick day management, exercise, knowledge of high and low blood sugar and foot care.  The diabetics expressed their interest to become “managers” in their own care.

Biography:

Abstract:

In the study was to investigate yogurts containing fish essential oil (EO) with sensory characteristics. Yogurt samples were categorised into five groups: C=control (with direct vat set starter culture), C1= 1% (sample with treated essential oil fish), C2=2% (sample with treated essential oil fish), C3=3% (sample with treated essential oil fish) and C4=4% (sample with treated essential oil fish) and stored at 4°C during 21 days. Samples were evaluated as color and appearance, texture, syneresis, flavor, acidity and general acceptability by 20 experienced panelists on the 1^st, 7^th, 14^th and 21^st days of storage. Of the different treated yogurt, both C1 and C2 yoghurt sample groups received higher scores in terms of total sensory characteristics (p<0.05). Panelists were thought to give low scores to overall flavor for the samples containing C4 by indicating a fishy taste and compared to other samples, C4 yoghurt samples were less preferred. It is a good way to elaborate food types by adding fish essential oil (EO) in them to improve their nutritional and physiological properties by regulating the rheological properties of the final product.

Biography:

Yu-Kuo Chen received his Ph.D. in the Institute of Food Science and Technology from National Taiwan University in 2009. After completing around two years as a postdoctoral associate in the Department of Chemical Biology at Rutgers University, he joined the faculty at National Pingtung University of Science and Technology as an assistant professor in the Department of Food Science. Dr. Chen’s research focuses on the biological evaluation of functional foods, purification and identification of active components in functional foods, and analysis of metabolism and bioavailability of those compounds

Abstract:

Our previous results demonstrated that 3'-hydroxypterostilbene (OHPt) has higher anti-tumor activity than pterostilbene (Pt) in vivo. In the present study, we would like to elucidate whether the stronger biological activity of OHPt is due to its higher bioavailability than Pt. We performed pharmacokinetic studies in male Sprague Dawley rats. The animals received a single oral administration of OHPt and Pt at the dose of 50 mg/kg through oral gavage. After oral administration, a series of plasma samples were collected at 0, 5, 10, 15, 30, 60, 120, 180, 240, 480 and 600 min for further HPLC analysis. The results showed that two unidentified metabolites without parent compound OHPt were observed following ingestion of OHPt; while only one metabolite (glucuronide/sulfate conjugates) and parent compound Pt were detected in rat plasma after ingestion of Pt. These results indicated that the biotransformation of OHPt might not be glucuronide or sulfate conjugation, whereas, the major biotransformation pathway of Pt might be glucuronide or sulfate conjugation. The findings of this study provide message that despite structural similarity, Pt and its hydroxyl analog OHPt exert completely differential effects on oral bioavailability and metabolism. Further experiment is needed to identify the unknown metabolites of OHPt

Biography:

Aysun Adan has her expertise in Molecular Biology of Cancer and Signaling Pathways, Natural Plant Products and Their Anti-carcinogenic potentials, Multidrug Resistance Mechanisms and Reversal of Resistance, Apoptosis, The Involvement of Bioactive Sphingolipids in Apoptosis and Drug Resistance, Combination Therapies, Stem Cells and Their Regenerative Potential

Abstract:

The studies elucidating the roles and the mechanisms of action of fisetin and hesperetin, plant flavonoids, in acute promyelocytic leukemia (APL) and chronic myeloid leukemia (CML) are absent. In this study, we investigated the mechanism of the antiproliferative and apoptotic actions exerted by fisetin and hesperetin on human HL60 APL and human K562 CML cells. The viability of HL60 and K562 cells was evaluated using the MTT assay, apoptosis by annexin V/propidium iodide (PI) staining and cell cycle distribution using flow cytometry, and changes in caspase-3 enzyme activity and mitochondrial transmembrane potential were determined. Moreover, we performed whole-genome microarray gene expression analysis to reveal genes and biological networks affected by KEGG and IPA analysis. For APL cells, both flavonoids showed a concentration- and time-dependent inhibition of proliferation and induced G2/M arrest and G0/G1 arrest for hesperetin at only the highest concentrations. There was a disruption of mitochondrial membrane potential together with increased caspase-3 activity. Furthermore, findcution of apoptosis was confirmed by annexin V/PI analysis. The microarray gene profiling analysis revealed some important biological pathways including MAPK and inhibitor of DNA binding (ID) signaling pathways altered by fisetin and hesperetin treatment as well as gave a list of genes modulated involved in cell proliferation, cell division, and apoptosis. For CML cells, fisetin and hesperetin inhibited cell proliferation and triggered programmed cell death. The latter was confırmed by mitochondrial membrane depolarization and an increase in caspase-3 activation. In addition to that, we have detected S and G2/M cell cycle arrests and G0/G1 arrest upon fisetin and hesperetin treatment, respectively. The microarray gene profiling analysis revealed some altered important signaling pathways including JAK/STAT pathway, KIT receptor signaling. They both significantly modulated the expression of genes involved in cell proliferation and division, apoptosis, cell cycle regulation, and other significant cellular processes such as replication, transcription, and translation. 

Biography:

Qian Li has her expertise in Food Nutrition and Health and just got her PhD in June 2016 from South China University of Technology, China. Her research program has been engaged in the scientific research on the structure identification and activity evaluation of natural products, polysaccharides and phenols. She have one year of study and research experience in Bioactive Natural Products and Phytoceuticals (BNPP) Lab of Michigan State University, College of Agricultural Natural Resources. She has published 9 articles in first author and 7 of them are high qualitied SCI. She has her expertise in the extraction, isolation, structure identification and structure-activity relationship of natural product. Her research program addresses all aspects of sericulture resources and Characteristic Lingnan fruits/vegetables nutrition, bioactive substances and the related functional evaluation since she got her job from Sericultural & Agri-Food Research Institute, Guangdong Academy of Agricultural Sciences, China.

Abstract:

Chinese yam polysaccharides were isolated using the method of boiled water extraction and stepwise ethanolic precipitation, combined with the tangential flow ultrafiltration membrane system. Their molecular weights were determined by high performance gel permeation chromatography. Three type yam polysaccharides in different molecular weight were isolated: HSY-I (> 50 kDa), HSY-II (10 ~ 50 kDa), HSY-III (< 10 kDa). The monosaccharide and glycosidic bond links composition were analyzed with GC and Smith degradation. The structure characteristics were further discussed combined with infrared spectrophotometry. Dexamethasone-induced insulin resistance glucose/ lipid metabolism diabetic mice model was established to evaluate the hypoglycemic effect of different concentration of HSY and different molecular weights polysaccharide HSY-I, HSY-II, HSY-III. The results indicated that the HSY polysaccharide mixture, HSY-I and HSY-II had auxiliary hypoglycemic effect. 

Biography:

Rany Adelina has her expertise in nutrition and health sciences. Her focus is to developing research in children and young adult nutrition She has finished her master in Nutrition and Health Sciences, Taipei Medical University, Taiwan  after years of experience in clinical and community nutrition research. Now, she is working as a faculty member for both teaching and doing research in Nutrition department, Malang health polytechnic, Malang city, Indonesia.

Abstract:

Statement of the Problem: The background of this study is referring to the phenomenon of Indonesian students who live on the outside from their hometown tend to have a careless eating habit. The difference in study location may cause a different type of eating habits between Indonesia and overseas, furthermore study intensity, meal preparation, and food access also may be influenced by this difference of study location. The purpose of this study is to determine the correlation between study location and eating habits for students who go abroad in Malang, Indonesia and in the city of Taipei, Taiwan.

Methodology & Theoretical Orientation: Subjects were Indonesian college students who live on the outside from their hometown for doing the study to Malang city, Indonesia and Taipei city, Taiwan. The total target sample was obtained as many as 493 respondents (397 respondents in Malang city and 96 respondents in Taipei City). Measured variables were studied intensity, meal preparation, food access, and eating habits in both two cities.

Findings: The Indonesian college students who lived in both Malang city and Taipei city, did not have the significant difference in eating habits. However, the trend showed healthier eating habits in Malang city.  On the other hand, study intensity, meal preparation, and food access were significantly different in both cities. Indonesian college students in Taipei tended to have higher prevalence of low study intensity, dependent meal preparation, and difficult food access. 

Conclusion & Significance: There is the significant correlation between study location and study intensity, meal preparation, food access, but not eating habits. Future research is needed to know the reasons for this insignificant correlation between eating habits in this two countries.

Biography:

Qunyu Gao is an affiliate of South China University of Technology, China

Abstract:

Sweet potato starch was subjected to cross-linking to achieve high content of resistant starch (RS) under heat-moisture treatment and the physicochemical properties of cross-linked sweet potato starches were investigated. A maximum RS content (72.45%) was obtained after 10% STMP/STPP (99/1% w/w) at 120℃ and pH 11.5 with a 20% moisture level. Through the analysis of 31P nuclear magnetic resonance (31P NMR) spectroscopy, the RS-72.45% contained distarch monophosphate (DSMP), not  be detected monostarch monophosphate (MSMP). After cross-linking, the starches with high moisture treatment (≥25%) were observed loss of birefringence and surface erosion. The X-ray diffraction patterns showed unchanged in crystal type but with slightly alteration in the relative crystallinity of cross-linked starches. The gelatinization temperature increased as the moisture content increased, while gelatinization enthalpy apparently decreased. 

Biography:

Yi-Zhen Chen is a second year master student in the Department of Food Science at the University of National Pingtung University of Science and Technology. She obtained her bachelor's degree in Food Science at NPUST in June 2015. She's full of great interests in the knowledge about food science. For her Master’s Thesis subject is the regulation effect of Djulis hull on blood lipids in hyperlipidemic hamsters. She has published one peer-reviewed research article in SCI international journal and five conference posters, and she has passed the required qualification examination for six technician certificates.

Abstract:

Heart disease and cerebrovascular disease are the second and third leading cause of death in Taiwan in 2015. Many studies showed that the most important factor leading to cardiovascular-related diseases is atherosclerosis, and the main caused by atherosclerosis is high blood cholesterol levels. Over the years, the risk of cardiovascular disease associated with population continues to increase, so the healthy diet and exercise have become one of the important issues. Djulis (Chenopodium formosanum) is a native cereal plant in Taiwan, and the djulis hull (DH) was found to be its major source of antioxidant compound. Studies showed that it possesses several active components with hypolipidemic activities, such as dietary fiber and polyphenol compounds. The objective of this investigation was to evaluate the regulation effects of DH in blood lipid levels to achieve the prevention of atherosclerosis effect. Five weeks old hamsters were randomly divided into five groups: (1) control group, (2) hyperlipidemic group (high fat diet containing 0.2% cholesterol; HFC), (3) low-dose DH group (HFC diet and treated with 100 mg/kg/day DH; LDH), medium-dose DH group (HFC diet and treated with 250 mg/kg/day DH; MDH), high-dose DH group (HFC diet and treated with 500 mg/kg/day DH; HDH). After 8 weeks of feeding study, the results showed that levels of triglyceride (TG; LDH: 194±31 mg/dl; MDH: 194±25 mg/dl; HDH: 204±26 mg/dl), total cholesterol (TC; LDH: 328±25 mg/dl; MDH: 301±21 mg/dl; HDH: 283±41 mg/dl) and low-density lipoprotein cholesterol (LDL-C; LDH: 165±33 mg/dl; MDH: 145±31 mg/dl; HDH: 140±28 mg/dl) in serum were significantly reduced by DH administration compared with those of HFC group (TG: 309±64 mg/dl; TC: 398±79 mg/dl; LDL-C: 184±31 mg/dl). Moreover, levels of TG and TC in liver were lower than HFC group, and levels of TG and TC in feces were higher than HFC group. These results indicate that DH possesses hypolipidemic potential to be a benefit functional food to prevent high fat/high cholesterol diet-induced hyperlipidemia.

Biography:

Jia Lin Guo study in national pingtung university of science and technology master’s degree program in food science, and he has expertise of HPLC analysis in natural compound.

Abstract:

Tangeretin (TAN), a kind of polymethoxyflavones (PMFs) found in citrus peels, has been proved to have many kinds of bioactivities including anti-inflammatory, anti-atherosclerosis and antitumor activities. Prostate cancer is universal malignant in male genital system. According to studies, 5-demethyltangeretin has hydroxyl group at the C₅ position, and higher cytotoxicity than TAN for cancer cells, but the low solubility of 5-DTAN limits their availability in biological system. For the reason that we prepared 5-DTAN derivative (with acetyl group at the C₅ position, 5-acetyltangeretin derivative; 5-ATAN), and hope to increase its solubility and bioavailability. The object of this study is to investigate the anti-proliferation and cellular uptake of 5-ATAN in PC-3 human prostate cancer cells. Esterase present in the cells, therefor, 5-ATAN will be converted to 5-DTAN when 5-ATAN was uptaken into cells. We could use high-performance liquid chromatography lined electrochemical detector (ECD) to detect concentration of 5-DTAN within PC-3 cell. In MTT assay, it demonstrated that 5-ATAN significantly inhibit growth of PC-3 cells in dose- and time-depend manners. In condition of HPLC-ECD showed that 300 mV is the best volt, and retention time of 5-DTAN is 11.6 minutes, and linear regression is 0.1-10 µM. Moreover, the quantification and detection limits (LOQ and LOQ) of 5-DTAN were 7.16 and 1.79 μg/ml, respectively. In bioavailability test, intracellular concentration of 5-DTAN of 5-ATAN-treated group was significantly higher than those of 5-DTAN-treated group, which showed dose- and time-depend responses. Overall, the results indicate that 5-ATAN showed highest anti-proliferation activity than TAN & 5-DTAN in PC-3 cancer cells, and had greater bioavailability than 5-DTAN. 5-ATAN will be expected to have better oral bioavailability in vivo.

Biography:

Ms  Marietta M. Bumanglag, RND,  is a Senior Science Research Specialist at the FNRI-DOST, the country’s lead agency in food and nutrition research & development. She obtained her  Master of Public Health from the University of Queensland, Australia.  Her project involvement includes Recipe development, Recipe/menu evaluation and Development of dietary tools :  recipe booklets  and Menu Guide Calendars (MGC) since 2004 as senior author. Her publication included the FNRI MGCs, LUTONG FNRI: Brown Rice recipes para sa Lahing Kayumanggi and Mga Katutubong Gulay, Recipe booklet utilizing malunggay leaves powder and yacon tubers, and Nutritious recipes for the FNRI supplementary feeding program

Abstract:

Failure to meet increased demands for energy and nutrients and poor eating habits have long term health, growth and development consequences in adolescents. A calendar to promote consumption of healthier meals in adolescents to help meet their nutrient needs through consumption of legumes and nuts was developed. The following activities were conducted: Focus Group Discussion (FGD) among panelists (n=8) to explore adolescents’ perceptions and insights towards food, eating behavior and food preferences; two (2) recipe trials and sensory evaluation to determine acceptability of recipes based on the Hedonic Rating Scale scores of sensory panelists (n=15; n=50) ; estimation of energy and nutrient content of recipes using the FCT + Menu Eval Software; photo-documentation and formulation of 4-week cycle menus. Themed “Helping meet the nutrient needs of adolescents through consumption of legumes and nuts”, the MGC 2016 highlights 15 recipes consisting of snacks, one-dish meal and viands incorporated in the 4-week cycle menu. The recipes utilized locally available and familiar legumes: green and red mung beans, lima beans, peanuts, white and red kidney/snap beans, pigeon pea and string bean seeds. Other features included articles on legumes and nuts, nutritional needs of teenagers and tips on encouraging teens to eat healthy foods and Pinggang Pinoy for teens, 13-18 years. The calendar may serve as a reference/guide for homemakers/food providers in preparing nutritious and varied meals, and a challenge for adolescents to try new and exciting recipes. The MGC is downloadable in the FNRI website for wider audience reach and dissemination

Biography:

He is Pu-Hua Wu, Taiwanese. He is a second year master student at Department of Food Science in National Pingtung University of Science and Technology. As its name, it is located at Pingtung, Taiwan, pure and simple counties. He was born and grown in Pingtung. So He has more emotion not only Pingtung but this school

Abstract:

In recent years, tempe (tempeh) is being more attention than before. Tempe (tempeh) originates from traditional food of Indonesia, is produced by termentation of soybean. Traditional tempeh only uses Rhizopus to ferment. Trying Lactobacillus co-culture with Rhizpous to create more comfortable condition for fermentation. Diabetes, an increasingly serious disease of modern civilization. A healthy body secretes insulin to regulate blood glucose by pancreas. Through the action of insulin so that glucose in the blood transport into cells to provide energy which cells need. When the level of insulin is not enough or inefficient use of insulin to reduce blood sugar in body, the problem of high blood sugar will occur. The most common diabete is type II, which is acquired diabetes. It is confirmed that aglycone can help regulation of blood sugar. Tempe has more aglycone than other soybeans product. This study observes changes of blood sugar in diabetic rats by fed tempe. To induce diabetes uses pharmacy with high-fat diet. Using streptozotocin (STZ) with nicotinamide induces rats to get diabetes and make sure their blood sugar above 150 (mg/dl). At same time, rats had fed high fat diet which include cholesterol, coconut oil and normal diet. Comparing tempe, tempe with Lactobacillus are useful with negative control and soybeans groups. Obviously, diabetic rats regulation of blood sugar with tempe are very useful.

Biography:

Ghazi Daradkeh is an affiliate of Department of Dietetics, ALkhor Hospital, Hamad Medical Corporation, Qatar

Abstract:

Background: Prevalence of overweight and obesity among children and adolescence over the past three decades reached an alarm­ing point in both developed and developing countries. As a result of the economic boom overweight and obesity has become a major health problem in the Arabian Gulf countries particularly in Qatar. Breakfast is considered to be the first and most important meal of the day. Breakfast skipping may be one of the complexes and multi-factorial causes of obesity.

Aims: The aims of this study were (1) to examine the prevalence of breakfast skipping among adolescent in the state of Qatar. (2) Evaluate the hypothesis that breakfast skipping would be associated with increased overweight and obesity and central obesity in the study population.

Method: A cross-sectional study was carried out among 1225 adolescents (625 boys and 600 girls) aged 15 to 18 years were selected by means of a multistage stratified random sampling technique from 14 public and 7 private schools between October 2012 and February 2013. Anthropometric measurements: Weight in (kg), height in (cm), Body Mass Index (kg/m²), waist circumference (cm) and waist to height ratio (WHtR) were measured/computed. Demographic data and Food habits were collected by using structured questionnaire.

Breakfast eating pattern was classified as: Breakfast eaters (students who are ate breakfast at least 4 days in a week). Breakfast skippers (students who skipped breakfast at least 4 days in a week).

Results: Breakfast skipping is a common unhealthy habit, out of 1225 participants 766 (62.5%) consumed breakfast less than daily. 52.5% of the participants were breakfast skipper (ate breakfast less than 4 times/week). Weight, Body Mass Index (BMI), waist cir­cumference (WC), was significantly different between participants age in both gender p< 0.05. The prevalence of overweight (43.0%) and obesity (39.5%) was lower among breakfast eaters than skippers (56.7% & 60.5%) respectively. In addition central obesity (WHtR ≥0.5) was more prevalent among breakfast skippers than eaters (59.3% vs 40.7%) respectively. A dose-response relationship was shown to exist between breakfast consumption and being overweight and obese among all students. This study showed that breakfast skippers were heavier than eater in both genders; body mass index was significantly higher among breakfast skippers.

Conclusion: Regular breakfast consumption is negatively associated with overweight and obesity among adolescents in Qatar, we found that breakfast skipping was prevalent in our study sample, and was associated with overweight, obesity and central obesity in both gender. Awareness programs about the importance of breakfast meal are needed for adolescents

Biography:

Chien-Hua Huang is a first year master student in the Food Science Department at National Pingtung University of Science and Technology. She has a great passion for food science and has the expertise in cell and animal experiments and biochemical techniques such as Western blotting. Chien-Hua Huang is studying the protective effect of Corbicula fluminea extracts in RGM-1 cell against indomethacin-induced gastric mucosal injury. She has published four posters, one of which was presented at the ISNFF International Conference in 2016

Abstract:

Tocotrienols and tocopherols, naturally occurring isoforms of vitamin E, are found abundantly in food such as palm oil, rice bran oil, corn, oats, barley, rye and wheat. Tocotrienols have four different isomers: α-, β-, γ- and δ-forms. The present study was designed to evaluate the protective effect of tocotrienols against methylglyoxal (MG)-induced cytotoxicity in human neuroblastoma SH-SY5Y cells. In order to assess the protective effect of tocotrienols, α-tocotrienol (α-T3), γ-tocotrienol (γ-T3) and δ-tocotrienol (δ-T3) were administered to SH-SY5Y cells for 2 hours prior to the induction of cytotoxicity by MG, and the cell viabilities of SH-SY5Y cells were analyzed by MTT assay. The cell viability of SH-SY5Y cells were reduced to 40% by 24 h treatment of 0.5 mM MG, and two hours pretreatment of α-T3, γ-T3 and δ-T3 increased the cell viability to 75%, 53% and 82%, respectively. It is shown that T3 has protective effect on the neuro-toxicity induction by MG. Among T3, δ-T3 has the best protective activity. The future work needs to be performed to elucidate the neuro-protective mechanism of T3.

Biography:

Abstract:

HPLC-fluorescence detectionï¼›LC-MS-MS

The identification and analysis of three anti-oxidants including: trans-resveratrol, quercetin and emodin in grape and red wine have been studied by HPLC-fluorescence and LC-MS/MS detection with SFE in this work.

Trans-resveratrol (trans-3,5,4'-trihydroxystilbene,resveratrol) is common found in grape and red wine. Trans-resveratrol (trans-RSV) has important effects on lipid metabolism and can be used as anti-inflammatory, anti-oxidant, free radical scavenging, and anti-allergy. It can also prevent the cardiovascular diseases. Besides, trans-RSV is also an effective cancer preventive medication. It can effectively inhibit tumor growth and cancer formation. Trans-resveratrol is sensitive to light and heat. Consequently, trans-RSV will convert to inactive cis-RSV.  The coexistence of antioxidants will also cause activity recession.

In this work, quercetin (2-(3,4-dihydroxyphenyl)- 3,5,7-trihydroxy-4H-chromen-4-one) and emodin (1,3,8-trihydroxy-6-methylanthracene- 9,10-dione are also studied for their interferences in the analytical procedure for trans-RSV. The sensitivity and recovery for the proposed method for natural trans- resveratrol from grape and red wine are also evaluated.

Biography:

Ching-Yi Kuan is a first year master student in the department of Food Science of National Pingtung University of Science and Technology in Taiwan. She has a great passion for food science. She can do cell experiments, Western blotting and animal experiments. She is studying the inhibitory activity of the stilbenes on liver cancer. She has published one poster in Taiwan Association for Food and Technology in 2015

Abstract:

According to the Ministry of Health and Welfare in Taiwan, prostate cancer is the sixth highest cause of cancer-related   death. Besides, prostate cancer cells will metastasize to bones and lymph nodes, so it’s important that prevention and treatment of prostate cancer. In this study, 3'-hydroxypterostilbene (OHPt), a structural analogue of pterostilbene (Pt), were used as experimental samples to investigate the potent anti-tumor effects in PC-3 xenografted nude mice. 1×10⁶ PC-3 cells were injected subcutaneously into the flanks of 30 male Balb/c nude mice to form tumors. When xenografted tumor volume reached around 100 mm³, mice were randomly divided into five groups. Each group consisted of 6 animals. Mice were orally administrated with daily doses of OHPt (5, 25 and 50 mg/kg/d) and Pt (25 mg/kg/d) for 4 weeks; while control group was orally administrated with olive oil only. During the experiment, the tumor volume was determined and recorded once or twice per week using caliper measurements. At the end of the experiment, animals were sacrificed by CO₂ asphyxiation and the individual tumors were excised immediately and weighed. Further the protein expression of tumors was measured. The results showed that the treatment of mice with OHPt could inhibit the tumor volume and tumor weight in a dose-dependent manner, and increased the expression of c-caspase-3 while decreased the expression of MMP-9 and Cox-2. In conclusion, these results revealed that OHPt might be a potential agent to treat prostate cancer.

Biography:

Abstract:

Introduction: Status epilepticus is a condition which has seizures more than 30 minutes without recovery between them. Seizures in the meningoencephalitis patients are caused by enhancement of emphasis and expansive of inflammation area in the brain. The ketogenic diet was given to the epileptic patient to minimize the seizures through some pathways such as: inhibit neurotransmitter release and activation of ATP-sensitive potassium channels, enhance overall bioenergetics and reduce oxidative stress, and modulate tricarboxylic acid flux.

Objection: The aim of this case study is to know the effectiveness of ketogenic diet in order to decrease seizures in a patient with status epilepticus. Method: This study was a case study which observed a patient (boy, 10 years old) at the Dr. Saiful Anwar Hospital, Indonesia, with status epilepticus and loss of consciousness. The ketogenic diet was given gradually, for 7 days (February 25th- March 3th, 2015), a patient was given pan enteral diet 1200 cc/day    (1200 kcal, protein 36.72 g, fat 61,8 g, and carbohydrate 130.8 g), for 9 days (4th-12th March  2015) received ketogenic diet 1600 cc  (2169.9 kcal,   protein 16.32 g, fat 107.2 g, and carbohydrate 280 g).

Result: Seizure decreased at the first day after ketogenic diet administration (seizures <30 minutes) and stop completely at second day after administration. Based on monitoring result, a patient had decreasing body weight and MUAC during ketogenic diet administration. Furthermore, patient had enhancement of lipid profile (total cholesterol 211 mg/dL, TG 256 mg/dL, HDL 32 mg/dL, dan LDL 146 mg/dL).

Conclusion: The ketogenic diet which given gradually can reduce and inhibit seizures in the meningoencephalitis patient.

Biography:

Taejoon Kang received a B.S. in chemistry from KAIST in 2004 and a Ph.D. in chemistry from KAIST in 2010. He did postdoctoral research at KAIST before joining in KRIBB as a senior researcher in 2012. He is currently senior researcher of BioNanotechnology Research Center and BioNano Health Guard Research Center in KRIBB and Associate Professor in major of Nanobiotechnology and Bioinformatics at UST

Abstract:

Rapid, specific and sensitive detection of pathogenic bacteria is crucial for public health and safety. Bacillus cereus is harmful as it causes foodborne illness and a number of systemic and local infections. We report a novel phage endolysin cell wall-binding domain (CBD) for B. cereus and the development of a highly specific and sensitive surface plasmon resonance (SPR)-based B. cereus detection method using the CBD. The newly discovered CBD from endolysin of PBC1, a B. cereus-specific bacteriophage, provides high specificity and binding capacity to B. cereus. By using the CBD-modified SPR chips, B. cereus can be detected at the range of 10⁵–10⁸ CFU/ml. More importantly, the detection limit can be improved to 10² CFU/ml by using a subtractive inhibition assay based on the pre-incubation of B. cereus and CBDs, removal of CBD-bound B. cereus, and SPR detection of the unbound CBDs. The present study suggests that the small and genetically engineered CBDs can be promising biological probes for B. cereus. We anticipate that the CBD based SPR-sensing methods will be useful for the sensitive, selective, and rapid detection of B. cereus.

Biography:

Abstract:

In a study of 224 patients, comprising 157 male patients and 57 female patients, to determine the correlations between Body Mass Index (BMI) and the risk of malnutrition, 124 patients were found to have BMI of 16.00-18.49 Kg/m2 while 54 patients were found to have BMI less than 16.00 Kg/m2. Using the same sample, an assessment of nutritional status of the patients using the Nutrition Alert Form shows that 78 patients had severe malnutrition while 112 patients had moderate malnutrition. In addition, by monitoring the change in patients’ weight over the course of 4 weeks, the study shows that 69 patients or 30 percent of the total sample experienced over 5% weight-loss, 36 patients or 16 percent experienced 2 - 5% weight-loss, and 108 patients or 48.2 percent experienced 1 – 2 % weight-loss. 160 patients had low Albumin serum with 143 patients having 2.0 - 3.5 mg% of Albumin serum and 17 patients having less than 2.0 mg% of Albumin serum.

Patients received Enteral Nutrition Support according to Nutrition Care Process for Cancer Treatment Plan with 115 patients or 51.3 per cent of the total sample receiving 1.2 kcal/1kd/d and 15-20 gm protein, 66 patients or 29.4 per cent receiving 1.25 kcal/1kd/d and 10 - 15 gm protein, 31 patients or 13.8 per cent receiving 1.5 kcal/1kd/d, and 12 patients or 5.5 per cent receiving 1 kcal/1kd/d and 20 - 40 gm protein. Our patient care team is a multidisciplinary patient care approach designed to implement a mixed and integrated patient care system. In particular, the pre-treatment nutritional care is central to the reduction of risk of malnutrition and allows quick and uninterrupted access to nutritional care through our Care Process.

Biography:

Chien is an assistant professor of food science, nutrition, and nutraceutical biotechnology at Shih Chien university in Taiwan. His research field included food analysis and bioassay especially focus on anti-cancer, anti-inflammatory, and analgesic effects by phytochemicals from food (Chien & Wang, 2016). Recently, he developing the anti-aging model to elucidated the protective effects of medical food on degenerative diseases such as osteoarthritis, sarcopenia, and neurodegeneration

Abstract:

As the world aging rapidly, neurodegenerative diseases became one of the most serious age-related health problems. In south Asia, several medical foods have been used as an anti-aging remedy since ancient times. Cordyceps (Paecilomyces hepiali mycelium), a traditional tonic, has been reported with various pharmacological activities. In this study, we utilized Drosophila model system mimicking Huntington’s disease (HD) to exam the neuroprotective effects of the ethanol extraction of P. hepiali mycelium (PHE). These HD flies are expressing motor dysfunction and early death. Results demonstrated that diet containing 1 mg/mL PHE could significantly prolong the mean lifespan up to 31% of flies by compared to the control diet. It was also found that PHE could improve the locomotor activity of flies at the young age (4 days). Besides, oxidative stress plays a causal role in the neurodegenerative process. PHE exhibit antioxidative properties in a concentration-dependent manner by using the DPPH radical scavenging and ferric ions reducing power assay. These results indicated that supplementation with PHE improved movement performance and longevity might contribute by its neuroprotective antioxidants. We suggest that the PHE can be developed as a potential dietary supplement against neurodegenerative diseases such as HD

Biography:

Abstract:

Objectives: To study and develop recipes from soy and soy-based products for female patients of OBGYN clinic at the Prince of Songkhla University Hospital who are in their menopause

Methodology: Developing 4 recipes from soy and soy-based products

Result: Southern Coconut-Rice with Chicken Curry provides the highest level of energy at 460 Kcal, followed by Stuffed Glutinous Rice Balls at 335 Kcal, Spicy Tofu at 270 Kcal, while Baby Mushroom provides the lowest level of energy at 190 Kcal. In addition, a look at how patients assess the recipes shows that the effectiveness of the recipe in controlling underlying medical conditions ranks highest with an average score of 4.43, followed by taste at 4.31, and presentation/appeal at 4.17. The assessment criteria with the lowest score was the ease of cooking, which only received 3.95 on average. The recipes were then assessed on 3 subsequent assessment criteria with the following results:

Taste: Stuffed Glutinous Rice Balls scored highest at 4.6, followed by Spicy Tofu at 4.3, and Coconut-Rice with Chicken Curry at 4.25. Baby Mushroom scored lowest at 4.1.

Presentation/Appeal: Spicy Tofu scored highest at 4.47, followed by Stuffed Glutinous Rice Balls at 4.2, while Coconut-Rice with Chicken Curry and Baby Mushroom received an equal score of 4.

Ease of Cooking: Spicy Tofu score highest at 4.2, followed by Coconut-Rice with Chicken Curry at 4, while Baby Mushroom and Stuffed Glutinous Rice Balls received an equal score of 3.8.

Biography:

Liezl M. Atienza has her expertise in human nutrition. She is a registered nutritionist-dietitian and an Asst. Professor in the University of the Philippines Los Banos. Her current researches are focused on lifestyle factors and metabolic syndrome as well as bioactive compounds in foods for the prevention and treatment of lifestyle-related and non-communicable diseases. She is also involved in delivering nutrition services thru the nutrition  clinic in the University and by serving as technical assistant and resource person to private companies, government and non-government organizations

Abstract:

Introduction: Oxidative stress and inflammation are known to play key roles in both pathogenesis and progression of diabetes mellitus (DM). The study aimed to determine the effects of red raspberries (Rubus ideaus L.) crude extract (RCE) on biomarkers of oxidative stress and inflammation in glucose-induced hyperglycemia in human umbilical vein endothelial cells (HUVECs) that mimicked hyperglycemia in DM. Methodology: The following were determined:1) bioactive compounds in red raspberries including a) dietary fiber; b) antioxidant activity; c) total polyphenol contents; and d)  identity of individual polyphenol, and 2) effects of raspberry crude extracts on biomarkers of oxidative stress and inflammation in glucose-induced hyperglycemic HUVECs in terms of a) ROS scavenging activity; b) lipid peroxidation inhibition activity; and c)  expression of transcription factors nuclear factor (erthyroid derived-2)-like (Nrf2), peroxisome proliferator-activated receptor-gamma (PPAR-γ) and nuclear factor-kB (NF-kB) and cytokine interleukin (IL)-6. Findings: Results revealed that red raspberries contain polyphenols such as quercetin and flavonoids that are known to exert strong antioxidant capacity. Results of in vitro study showed that RCE attenuate oxidative stress by significantly inhibiting reactive oxygen species (ROS) (p<0.05) and lipid peroxidation (P<0.05). However, at higher concentration (20ug/mL), RCE behaved as pro-oxidant and significantly decreased cell proliferation (p<0.05). Also, RCE was observed to interact with molecular signaling pathways that are involved in oxidative stress and inflammation. It significantly up-regulated the expression of transcription factors Nrf2 and PPAR-γ in non-dose dependent manner. Also, RCE significantly down-regulated the expression of pro-inflammatory transcription factor NF-kB and inflammatory IL-6 in dose-dependent manner. Conclusion and Recommendation: Given these findings, in vitro and in vivo studies focused on signaling pathways and molecular targets using different varieties of raspberries merit further investigations

Biography:

Cherry Ann Garcia is a Master in Science in Public Health Major in Nutrition. She worked as a Nursing Review Lecturer for Medical-Surgical Nursing and Maternal and Child Nursing. 

Abstract:

In the Philippines, 2-3 out of 10 children suffer from atopic dermatitis (AD) or eczema. The most common treatment of atopic dermatitis is the application of topical corticosteroids especially for acute exacerbation. Antihistamine is also given to reduce the pruritus. However, despite the presence of pharmacological management, prevention of attacks by identifying and avoiding triggering factors is the focus of health teaching for parents of children with AD. Food allergy is found to co-exist in approximately 40% of children with moderate to severe AD. Nonetheless, potential food allergens can be difficult to avoid because most common food triggers are egg, milk, wheat, peanut, and soy, which are used in many food preparations. For this reason, the research community is investigating possible innovative prevention and treatment strategies for atopic dermatitis. One of these strategies is the manipulation of the intestinal flora through probiotics. Probiotics are defined by the FAO/WHO as “live microorganisms which when administered in adequate amounts, confer a health benefit on the host.” One of the biggest companies that supplies probiotic drink in the country released their annual report in 2014, and about 15% of the total population avails of the probiotic drink with average sales of 15.9 million bottles in one day. Despite of this data, there is very little research on the specific reasons why consumers avail of probiotics. Furthermore, the perspective of mothers on probiotics and its use is an area of research that is not yet explored, evidenced by the lack of published works in local peer-reviewed journals. Through a face-to-face interview using a guide questionnaire, this cross-sectional study gathers information on maternal perspectives on probiotics. A food frequency questionnaire is used to determine the frequency and amount of probiotic food consumption by the child. Using the diagnostic criteria in the ISAAC (International Study of Asthma and Allergies in Childhood) questionnaire, a medical doctor collects data on eczema. The results will hopefully reveal the effect of probiotic consumption to the occurrence of atopic dermatitis in children age four to five.

Biography:

Nindy Sabrina is a second year master student in the School of Nutrition and Health Sciences, Taipei Medical University, Taiwan. Nindy originally from Malang, Indonesia. She received her undergraduate education at Brawijaya University, Indonesia, with a degree in Nutrition and Health. Currently, she is actively involved in Indonesia Student Association in Taiwan. Nindy is broadly interested in human nutrition research particularly obesity, iron, and advanced glycation end products. In her master research, she is seeking to understand the relationships between dietary intake, serum iron biomarkers and advanced glycation end products in Non-Alcoholic Fatty Liver Disease (NAFLD) patient in Taipei

Abstract:

Background: Recent evidence suggests that calorie restriction (CR) is more effective for obesity treatment that dietary fat restriction. Meal replacement (MR) also have shown as an effective strategy for the long term maintenance of weight loss compared with a traditional reduced calorie diet regimen. However, it is not clear whether combination between calorie restriction with meal replacement diet (CRMR) would promote favorable change in body weight and body composition. The aim of this study was to compare the effects of dietary intervention focusing on either calorie restriction alone or calorie restriction plus meal replacement on weight loss and body composition.

Subjects/Methods: The 99 eligible subjects were randomized to either 1500-kcal CR and CRMR groups for 12 weeks. The CRMR group was supplied with low-calorie nutrition drink mix powder. The changes in anthropometry and body composition were evaluated. Body composition was measured with dual energy x-ray absorptiometry (DEXA).

Results: Seventy subjects have completed the study. During weight loss period, body weight and body mass index (BMI) decreased similarly (P<0.001) in the CRMR group (-7.39 ± 5.09 %;-7.40 ± 5.10 %, respectively) and CR group (-2.31 ± 2.07 %; -2.31 ± 2.09 %, respectively). Waist circumference decreased similarly (P<0.001) in the CRMR and CR groups (-6.80 ± 7.59 % and -5.96 ± 4.80 % respectively). Fat mass decreased more (P<0.001) in the CRMR group (-15.99 ± 9.37 %) versus the CR group (-4.20 ± 6.82). Android fat and gynoid fat decreased similarly (P<0.001) in the CRMR group by -7.44 ± 7.82 % and -3.26 ± 7.16 %, respectively.

Conclusion: These findings suggest that CRMR is effective to body weight and body composition of obese in comparison with CR alone

Biography:

Networking & Lunch

Abstract: