Jin Yong Kang
Gyeongsang National University, Korea
Title: Relative physiological activity of chlorogenic acid and 3,5-dicaffeyolquinic acid on problems caused by high-fat diets
Biography
Biography: Jin Yong Kang
Abstract
This study was performed to confirm the influence of chlorogenic acid (CGA) and 3,5-dicaffeyolquinic acid (3,5-diCQA) intake on disorders caused by high-fat diets. They have been shown to improve impared glucose tolerance and inhibit weight gain caused by high fat diet although CGA and 3,5-diCQA differ in their activity. In biopsy, it is confirmed that CGA inhibits visceral fat and liver fat accumulation, and 3,5-diCQA also inhibited visceral fat accumulation, but a 3,5-diCQA increased liver fat accumulation. Both CGA and 3,5-diCQA inhibit accumulation of visceral fat by stimulating AMPK phosphorylation in epididymal white adipose tissue. CGA also increased AMPK phosphorylation in the liver tissue, but 3,5-diCQA reduced AMPK phosphorylation. This result in liver tissue is presumed to be related to Akt phosphorylation. AKT phosphorylation was significantly increased in liver of the 3,5-diCQA group. Increased AKT phosphorylation improved glucose tolerance, but it inhibted AMPK phosphorylation and thereby increase fat accumulation in liver. In addtion, as a result of confirming the degree of liver damage, the liver fat accumulation induces oxidative stress, but 3,5-diCQA reduced oxidative damage through its antioxidant activity. To sum up, a CGA is effective in improving the problems caused by high-fat diets while maintaining balance. A 3,5-diCQA also has shown a positive effect on problems caused by high-fat diets, but it increased liver fat accumulation and thereby cause negative consequences.