Xiaoxia Dai
Xi′an Jiaotong University Health Science Center, China
Title: Selenium increase the clearance of immune complexes in Kashin-Beck Disease, an endemic osteochondropathy
Biography
Biography: Xiaoxia Dai
Abstract
Many studies suggest that adequate intake of Se is required to ensure optimal immune function and to prevent malignancy. Various components of the immune system fail to function correctly if there is dietary Se deficiency. In the present study, the effect of selenium supplements on the clearance of immune complexes of patients with KBD was evaluated. The effect of different selenium preparations on (1) erythrocyte selenium content, (2) activities of glutathione peroxidase, (3) erythrocyte immune adherence function, and (4) circulating immune complexes (CIC) content of patients with KBD was determined. The effect of sodium selenite and selenium yeast were also compared.
In this randomized study, fifty Kashin-Beck disease patients from the endemic area, aged 13-16 years, were divided into two groups and were given either selenium yeast or sodium selenite orally to provide 200µg of selenium per day for 12 weeks. After supplementing with selenium for 12 weeks, erythrocyte selenium level, glutathione peroxidase activity, and E-C3bRR showed significantly high values, the difference in E-ICRR content was not significant. The effect of selenium in enhancing blood selenium levels and the clearance of immune complexes is greater when supplements provided as selenium yeast is used as compare to sodium selenite. This work was supported by the National Nature Scientific Foundation of China (Grant No. 81673117 and 81573140).