Serkan Aslan was graduated from the Department of Nutrition and Dietetics, Afyon Kocatepe University in 2013. He began his Master\'s program at Gazi University, Institute of Health Science in Nutrition in 2014. He is currently studying the determination of nutrition and appetite status in drug addicts.
Drug addiction is one of the most struggling social and health problems worldwide. Various factors determine the efficiency and duration of the addicts’ treatments. One of these factors is nutritional status. Because of drug addiction, individuals slight their nourishment. Several reasons such as particularly drug abuse related loss of appetite, budget and sleep duration cause this situation. Relating to the subject, various literature searches has been done in databases. Even though eating and drug abuse look like separate conditions, actually they both have many neural similarities. Nerve fiber bundles that reach the structure called nucleus accumbens excrete great amount of neurotransmitter dopamine. When a hungry individual finds food, this structure fills up with dopamine. Likewise, cocaine and amphetamine increase the level of dopamine in this structure and cause a wave of pleasure. This situation is one of the factors that diminish appetite of drug addicts. Many of the drug addicts, especially opium addicts have undernutrition in terms of macro and micro nutrients and therefore malnutrition may be occurred. Food consumption preferences of addicts cause malnutrition as well. Addicted individuals’ fruit, vegetable or dairy products consumptions are in small quantities. Changes in drug addicts’ nutritional status serve positively in treatment. Inadequate and unbalanced nutrition related to loss of appetite is a frequent situation that’s seen in the drug addicts. Bettering of nutrition status has important effect on treatment of addicts. Therefore, it’s beneficial to provide adequate and balanced nutrition to drug addicts.
rnKirbaeva Natalya Viktorovna is a Junior Researcher in the Laboratory of Metabolomic and Proteomic Analysis in Federal Research Centre of Nutrition and Biotechnology, Moscow, and performing her PhD. She has published more than 20 papers in reputed journals.rn
Purpose: The brain is the most sensitive structure to stress. It has been shown that stress produces neurochemical and behavioral changes associated with prefrontal cortex function. Limbic system, in particular amygdale, affects the stress-dependent behavior, initiating emotionally motivated responses. A number of data has demonstrated the correlation between rat\'s physiological ability to adaptation to stress and their behavioral type. To identify proteomic features in rat brain departments caused by metabolic stress, we performed comparative proteomic analysis.rnrnExperiment: Wistar male rats were divided into 2 groups of behaviorally passive and active animals. Starvation of rats (water ad libitum) during 5 days served as a model of acute metabolic stress. There was a 5 day recovery period after the starvation, while animals received a standard diet. The protein expression profiles of amygdale and cortex were studied by using two-dimensional electrophoresis and MALDI-TOF.rnrnResults: The proteomic analysis showed the up- and down-regulated expression of calcineurin B homologous protein 1, peroxiredoxin 2, tropomodulin 2, glutathione S-transferase omega 1, Tcrb protein, GTP-binding protein SAR1a, NADH dehydrogenase [ubiquinone] Fe-S protein 8, Ras-related protein Rab-14, NADH dehydrogenase [ubiquinone] flavoprotein 2, OTUB1, serine/threonine protein phosphatase 1 (PP1),cell division control protein 42 homolog (CDC42),proteasome subunit beta type-2 (PSB2),14-3-3 epsilon, alpha-synuclein in amygdale and cortex depending on behavioral type of rats and the stage of stress.rnrnConclusions: Individual behavioral features affect the specific pathway of organism response to the stress and determine an adaptive potential of the organism. rn