Biography:

Roni Lara Moya has done his studies in Biomedicine from the University of Mogi das Cruzes, Sao Paulo. He has done his specialization in Anti-Aging Medicine from Seville University, Spain. He completed his Master of Science in Molecular and Cellular Immunology and Biology from the University of Coimbra, Portugal and Master of Science in Clinical Advanced Nutrition from the University of Barcelona, Spain. He did his PhD in Biomedicine and Immunology from the Gulbenkian Institute of Science and Coimbra University. He is the Coordinator of Orthomolecular Medicine of ReGenera Research Group for Aging Intervention. He is the Professor and Director of the Graduation Program in Orthomolecular Therapy-CESPU University, Portugal. He is the Scientific Advisor for Nutraceuticals and Cell Therapy Companies in Europe.

Abstract:

The state-of-the-art advances in neuroscience and anti-aging medicine show that the brain can adapt to chronic stress by increasing its neuroplasticity capacity. Neuroplasticity allows the neurons in the brain to compensate for injury and disease and to adjust their activities in response to new situations or to changes in their environment. The aging brain can adapt through cellular defences mechanisms, such as DNA repair, release of neurotrophins (BDNF, IGF-1), promotion of neurogenesis and also through the capability of the dendrites and synapses to change in response of the environmental demands, including nutrition. The brain’s perfect immunity regulation by the microglia and the central nervous system’s antioxidant capacity enhancement depends on several concepts, including the best nutritional foods and supplements, hormones, physical activity and learning procedures. The orthomolecular medicine establishes the use of the correct molecules to keep the perfect physiological and biochemical function of the body. The aim of this talk is to reveal the biochemical and immunological mechanisms behind the brain aging and to address the best clinical orthomolecular protocols to prevent the neurodegenerative diseases and stimulate the neuroplasticity with the use of dietary substances, natural immune-modulatory molecules and bioidentical hormones.

Biography:

Kaj Winther was earlier deeply involved in cardiovascular research and medicine with special reference to thrombosis and haemostasis and worked for a period at the Harvard Medical School, Boston, on the topic “Circadian Variation in Myocardial Infraction”. Later in his career, he more and more focused on development and clinical testing of herbal remedies and different versions of new foods. His interest in food and herbal remedies is also based on the fact that much prescription medicine including the non-steroidal anti-inflammatory drugs (NSAID’s) are blamed for serious side effects. As many of our top athletes and more and more of the average population trying to get into a “better shape” is abusing NSAID’s, more attention should be drawn to develop new “pain-killers” without serious side effects.

Abstract:

Statement of the Problem: Strenuous exercise results in muscle pain and stiffness. This can reduce training capacity, success during competition and quality of life, especially if optimal daily performance is mandatory as in bicycling (Tour de France) or in team sports (hockey and soccer) where tournaments can go for days. Non-steroidal anti-inflammatory drugs (NSAID`s) reduces muscle symptoms. However, gastro intestinal “side effects” occur. This research aims to clarify if powdered rose hip, subspecies LiTo, containing galactolipid GOPO and seeds alleviates muscle pain and stiffness observed after exercise.

Methodology & Theoretical Orientation: Randomized, placebo controlled studies were conducted on 76 horses (trotters) and on 44 greyhounds treated 0.1 – 0.3 g powder/kg body weigh daily, for three months. The staff around the animals evaluated muscle pain and stiffness on questionnaires and animal competition speed. Healthy, human, middle age, modestly trained volunteers in randomized, double-blind placebo-controlled design and 18 younger trained volunteers (cross-fit), in open trial, were given the same treatment, in lower dose, for at least 3 months.

Findings: In horses and greyhounds rose-hip treatment reduced muscle pain and stiffness when evaluated vs. placebo the day after competition (p<0.048). Active treatment improved the speed of animals to some extent. In modestly trained human volunteers active treatment resulted in a significant decline in reported muscle stiffness and pain (p<0.045) and in an increase in the quality of life (p<0.040). The younger group of intensively trained cross-fitters reported a significant decline in pain and stiffness the day after strenuous exercise (p<0.020) and in an improvement of quality of life (p<0.035).

Conclusion & Significance: The data suggest that the present rose hip food supplement alleviate pain and stiffness caused by exercise in animals and humans. The present remedy might reduce NSAID abuse in sportsmen and in ordinary people who want to improve their physical performance.