Day 2 :
CESPU University, Portugal
Time : 10:00-10:40
Roni Lara Moya has done his studies in Biomedicine from the University of Mogi das Cruzes, Sao Paulo. He has done his specialization in Anti-Aging Medicine from Seville University, Spain. He completed his Master of Science in Molecular and Cellular Immunology and Biology from the University of Coimbra, Portugal and Master of Science in Clinical Advanced Nutrition from the University of Barcelona, Spain. He did his PhD in Biomedicine and Immunology from the Gulbenkian Institute of Science and Coimbra University. He is the Coordinator of Orthomolecular Medicine of ReGenera Research Group for Aging Intervention. He is the Professor and Director of the Graduation Program in Orthomolecular Therapy-CESPU University, Portugal. He is the Scientific Advisor for Nutraceuticals and Cell Therapy Companies in Europe.
The state-of-the-art advances in neuroscience and anti-aging medicine show that the brain can adapt to chronic stress by increasing its neuroplasticity capacity. Neuroplasticity allows the neurons in the brain to compensate for injury and disease and to adjust their activities in response to new situations or to changes in their environment. The aging brain can adapt through cellular defences mechanisms, such as DNA repair, release of neurotrophins (BDNF, IGF-1), promotion of neurogenesis and also through the capability of the dendrites and synapses to change in response of the environmental demands, including nutrition. The brain’s perfect immunity regulation by the microglia and the central nervous system’s antioxidant capacity enhancement depends on several concepts, including the best nutritional foods and supplements, hormones, physical activity and learning procedures. The orthomolecular medicine establishes the use of the correct molecules to keep the perfect physiological and biochemical function of the body. The aim of this talk is to reveal the biochemical and immunological mechanisms behind the brain aging and to address the best clinical orthomolecular protocols to prevent the neurodegenerative diseases and stimulate the neuroplasticity with the use of dietary substances, natural immune-modulatory molecules and bioidentical hormones.
University of Copenhagen, Denmark
Keynote: Can rose hip containing seeds and high amount of GOPO shorten the recovery phase after strenous exercise: A comparative study in animals and humans
Time : 10:40-11:20
Kaj Winther was earlier deeply involved in cardiovascular research and medicine with special reference to thrombosis and haemostasis and worked for a period at the Harvard Medical School, Boston, on the topic “Circadian Variation in Myocardial Infraction”. Later in his career, he more and more focused on development and clinical testing of herbal remedies and different versions of new foods. His interest in food and herbal remedies is also based on the fact that much prescription medicine including the non-steroidal anti-inflammatory drugs (NSAID’s) are blamed for serious side effects. As many of our top athletes and more and more of the average population trying to get into a “better shape” is abusing NSAID’s, more attention should be drawn to develop new “pain-killers” without serious side effects.
Statement of the Problem: Strenuous exercise results in muscle pain and stiffness. This can reduce training capacity, success during competition and quality of life, especially if optimal daily performance is mandatory as in bicycling (Tour de France) or in team sports (hockey and soccer) where tournaments can go for days. Non-steroidal anti-inflammatory drugs (NSAID`s) reduces muscle symptoms. However, gastro intestinal “side effects” occur. This research aims to clarify if powdered rose hip, subspecies LiTo, containing galactolipid GOPO and seeds alleviates muscle pain and stiffness observed after exercise.
Methodology & Theoretical Orientation: Randomized, placebo controlled studies were conducted on 76 horses (trotters) and on 44 greyhounds treated 0.1 – 0.3 g powder/kg body weigh daily, for three months. The staff around the animals evaluated muscle pain and stiffness on questionnaires and animal competition speed. Healthy, human, middle age, modestly trained volunteers in randomized, double-blind placebo-controlled design and 18 younger trained volunteers (cross-fit), in open trial, were given the same treatment, in lower dose, for at least 3 months.
Findings: In horses and greyhounds rose-hip treatment reduced muscle pain and stiffness when evaluated vs. placebo the day after competition (p<0.048). Active treatment improved the speed of animals to some extent. In modestly trained human volunteers active treatment resulted in a significant decline in reported muscle stiffness and pain (p<0.045) and in an increase in the quality of life (p<0.040). The younger group of intensively trained cross-fitters reported a significant decline in pain and stiffness the day after strenuous exercise (p<0.020) and in an improvement of quality of life (p<0.035).
Conclusion & Significance: The data suggest that the present rose hip food supplement alleviate pain and stiffness caused by exercise in animals and humans. The present remedy might reduce NSAID abuse in sportsmen and in ordinary people who want to improve their physical performance.
Title: “Tribitor® reduces caloric impact of sugar, glycaemic index of food & glucose and insulin spikes after high carbohydrate meals” – the latest clinical studies
Time : 12:40-13:40
Theodora Mantzourani BSc, MD, MRCGP, MSc, DipNutMed is a GP Specialist in Endocrinology & Diabetes, Nutritional and Preventive Medicine. She is an expert in bioidentical hormones and their use in wellbeing, antiaging and cosmeceuticals. She has a special interest in obesity and obesity-related disease such as insulin resistance and metabolic syndrome. She is an international speaker and a member of IFM and AAFARM. Her scientific research is on Reproductive Endocrinology.
All dietary carbohydrates get converted into glucose after digestion. Carbohydrate digestion and absorption is a multistage process involving enzymes and transporter proteins. High Glycemic Index (GI) carbohydrates break down fast during digestion and release glucose rapidly into the bloodstream; low GI carbohydrates breaks down more slowly and release glucose more gradually. High intake of carbohydrates especially those with high GI together with environmental factors contribute to obesity, metabolic syndrome and diabetes. A new product (Tribitor®) was developed during animal and human studies. During OGTT animal studies performed in rats, different plant extracts were tested for their hypoglycemic effects and after performed comparisons, the plant extracts with the highest hypoglycemic capacities were included into combinations tested for best synergistic hypoglycemic effect. The combination of three extracts with the greatest ability to lower postprandial glycaemia was chosen for further testing in humans. Two randomized, double- blind, placebo controlled studies were performed to GCP standards to verify the hypoglycemic effects of Tribitor®. The effects of this preparation on blood glycaemia were monitored after consumption of different meals. Statistically significant reductions of glucose and insulin peak levels were observed, particularly during the first phase of the test. Reactive hypoglycemia events were observed significantly less frequently when Tribitor® was given before meals. It was also found in a follow-up study, that Tribitor® had the ability to lower the Glycemic Index of white bread.
Poster Presentation 14:00-15:00 @ Avila
- Paediatric Nutrition | Nutrient in Cancer & Chronic diseases | Nutrition in Pregnancy and Lactation | Nutrition during Adolescence | Nutrition, Health and Aging | Nutrition and Psychology | Food and Nutrition | Nutrition Epidemiology | Current Research in Nutrition and Dietetics | Nutraceuticals & Medicinal Foods | Animal and Diary Nutrition
Zurich University of Applied Sciences, Switzerland
National Institute of Nutrition, India
University of Valencia, Spain
Time : 11:40-12:10
Maria J Esteve is an expert in food analysis. She has studied the effect of non-conventional conservation treatments (electrotechnologies, high pressures and ultrasounds) on physicochemical characteristics, nutrients and bioactive compounds of foods of vegetal origin. In her last project she studies the valorization of residues of the food industry with the extraction by non-conventional techniques of bioactive compounds (phenolic compounds, ascorbic acid, carotenes) and colored compounds. She also studies the possible interactions between the compounds as well as their bio accessibility and the effect that different technologies can have. The effect on the health of the consumer is important but also the interest to reduce the environmental impact has increased, reason why it is looked forsustainable processes.
Childhood obesity is one of the main public health concerns. In 2016, the WHO publishes a report that includes a set of recommendations to combat childhood obesity, but also calls on governments of member countries to promote policies to reduce the numbers of overweight and obesity. The school canteens play a fundamental role in the field of infant feeding due to its high number of users, which reached its peak in Spain in 2010-2011, with 1,675,681 users, corresponding to 40.8% of the total Students enrolled in primary and secondary education (Oficina de Estadística del Ministerio de Educación, Cultura y Deporte, 2014). The objective of the present work is to determine the quantity and quality of the fat of the menus served in school canteens. The study is carried out in the four schools (A1, A2, C and D), with a population of 1877 students and 582 regular diners. The management of the school dining service is carried out by 3 different catering companies. Of the four schools, two have autonomous kitchen (A1 and A2) and the other two refer catering service. The menus are collected in one week in each of the schools and the fat is determined using the modified method of Rose Gottlieb and the lipid profile by gas chromatography. The results are compared with those obtained using composition tables.
The fat content is 5.4±3.0, 5.1±2.1, 3.4±0.5 and 4.3±0.7 g / 100 g of the menu in school A1, A2, B and C, respectively. The fatty acid profile is shown in Table1. The results obtained show the importance of not only controlling the amount of fat added during the preparation of the dishes, but also the type of fat used (lipid profile).
Zurich University of Applied Sciences, Switzerland
Time : 12:10-12:40
Christine Brombach is working as Lecturer at the Institute of Food and Beverage Innovation at Zurich University of Applied Sciences, Switzerland since 2009. She received a degree in Home Economics and Nutrition from the University of Giessen, Germany and a Master of Science in Nutrition with a major in Gerontology from Manhattan, KS, USA. She did her PhD at the University of Giessen, Germany on the topic of “eating behaviour in the life course of women over the age of 65 years”. She was project coordinator of the Nutrition Survey II at the Max Rubner Institute, Karlsruhe in Germany before she moved to Switzerland.
Statement of the Problem: Eating behavior is predominantly learnt in childhood during socialization, growing up in a cultural context. Family, parents, (great) grandparents play an integral important role. Development of meals, eating practices should be considered in the context of intergenerational influences. It was the aim of this qualitative study to investigate influences on eating behaviour in a German family living in South-West Germany. The family is unique, most of descendants of the “parents” (F1) (born end of 19th century) still live in proximity. F2 are children, F3 grandchildren, F4 great grandchildren, F5 great great grandchildren. F1 parents had 15 children (two daughters still alive, 90, 86 years), there are 32 grandchildren, 50 great grandchildren and F5 (as today) more than 10 great great grandchildren.
Methodology & Theoretical Orientation: A written survey was conducted with as many family members as possible and where feasible in depth qualitative interviews were conducted. Thereby a hermeneutic interpretation cycle was used to develop themes and topics on meals and meal practices.
Findings: At present the study is still ongoing. Preliminary findings: The predominant role of women in meal preparation, use of family recipes, rituals can be traced into the F4 generation. It seems that the matrilineal dissemination of meal structures and meanings, family recipes, use of cherished cookbooks, rituals is stronger than in the patrilineal way.
Conclusion & Significance: This is a pilot and exploratory study so results may not be generalized and should be interpreted with caution. Nevertheless, some aspects and comparison with other studies are striking such as a previously conducted three generation approach in German sample, where also similarities can be traced within a three generational approach. So far very few studies have been conducted in a three generational approach let alone in multi-generational approach in one family. Findings might help to better understand onset of eating practices.
National Institute of Nutrition -ICMR, India
Time : 15:00-15:30
N Arlappa has completed his MD in Community Medicine from the NTR University of Medical Sciences, Vijayawada, India. He has been working as Nutrition Scientist in the Division of Community Studies, National Institute of Nutrition (NIN), Indian Council of Medical Research, Hyderabad, India. He has 20 years of research experience in the field of Public Health Nutrition and has published more than 60 scientific papers in peer-reviewed national and international journals. He has published 4 book chapters and one book on vitamin A and has completed more than 40 research studies and published more than 250 technical reports out of them. He attended and presented more than 25 scientific papers in national and international conferences/workshops. He is the faculty of the courses of MPH (NIE), MSc (Nutrition) and PG Certificate course in Applied Nutrition, conducted at NIN. He is currently serving as Deputy Director (Scientist-E).
Introduction: Rapid nutrition transition is taking place worldwide, especially in developing and underdeveloped countries. As a part of it, there was an increased demand for domestic production and import of oilseeds and vegetable oils from other counties. Consequently, there is a marked increase in consumption of edible oils in India populations; from 31.4 g/d/capita in 1993–1994 to 41.6 g/d/capita in 2011–2012. In India, vegetable oils used in cooking represent 80% of the visible fat and there has been a shift from traditional groundnut oil to other oils such as palmolein, mustard, sunflower oils and increased consumption of ghee.
Objective: The objective of this communication is to study the trends in consumption pattern of Fats and Oils among Indian population.
Materials & Methods: National Nutrition Monitoring Bureau (NNMB) has been carrying out large scale community based cross-sectional studies in rural, tribal and urban areas of different States of India, covering two-thirds of its geographical area. The latest surveys carried out by the NNMB and other organisation on diet and nutritional status of rural, tribal and urban areas was utilised for this communication. Use of different cooking oils and consumption patterns of visible and total fats obtained through 24-hour recall diet survey among the rural and tribal populations by age group, literacy status and occupation was analysed and presented.
Results: Majority of households in India were using mustard oil for cooking purpose followed by groundnut, palm oil, soybean oil, coconut and sunflower oil. In general, at household level, the intakes of visible fats are less than RDI (20 gr), and the deficit intake of total fat was >50% of RDA during three time points among tribal and rural population. Similarly, the intake of total fat was grossly deficit against the RDA (40 mg) across all the age groups and genders. Likewise, the mean household intakes of visible fats were below the RDIs among urban populations. However, the adequacy (≥70% of RDA) of consumption of fats was higher among the adults (≥18 years) as compared to adolescents and children.
Conclusions: In general, the dietary consumption visible fats as well as total fats were grossly deficit among tribal, rural and urban population of India.
Cen Nutriment Dijon, France
Title: Chitosan reduces hypertensive toxicity of the NaCl: results of a randomised double blind cross over clinical trial
Time : 15:30-16:00
Medical doctor specialised in Public Health, PhD in biostatistics and Pharm D, Pr Francois-André Allaert is strongly involved in the field of medical evaluation and especially in the evaluation of health claim. He is managing a human clinical center specifically approved by French health authorities for food supplement and enriched food evaluation. He is also managing the chair for health claim medical evaluation at the burgundy university of Dijon. He is authors of more than 1500 scientific oral communications and publications among which 210 are pubmed referred.
Study context:. Hypertensive patients have difficulties to reduce salt intake and one new strategy is not only to reduce the salt quantity but also its hypertensive toxicity.
Main objective: The main objective was to compare the decrease of the high blood pressure (HBP) parameter with Symbiosal (NaCl + Chitosan 3%) and with NaCl during the diet and lifestyle improvement period before an eventual antihypertensive treatment
Study design: Double blind, randomized, cross over, controlled clinical trial of Symbiosal (NaCl + Chitosan 3%) vs NaCl on two groups of 20 patients during two periods of 8 weeks. Inclusion criteria: Men and women older than 18 years presenting a mild hypertension defined by a SBP between 140-159 mmHg and a DBP between 90-99 mmHg g and having never been treated with an antihypertensive drug.
Results: 40 patients were included and the effect of Symbiosal appeared as soon as the first period of the cross over showing a decrease of the SBP from 149.2 ± 4.9mmHg to 136.1 ± 9.5 mmHg in patients for which Symbosial was available (decrease of 13.1 ± 10.8 mmHg) versus a decrease from 149.7 ± 4.6 mmHg to 142.9 ± 7.7mmHg in patients eating traditional NaCl (decrease of 6.8 ± 7.5mmHg) (p=0.0404). Similar results were observed with DBP with a decrease of 11.2 ± 7.4mmHg vs 7.0 ± 8.0mmHg (p=0.0560). HBP was controlled (SBP<= 140 and DBP<=90) in respectively 76.2% (16/21) vs 36.8% (7/19)% (p:0.0119). The cross over analysis on the two periods confirmed the results. The salt intake was relatively moderate in both groups: 2.9 ± 1 g/d vs 3.0 ± 1.5 g/d ( p: 0.9412 NS).Conclusion. Switching traditional NaCl by Symbiosal significantly contributes to a better control of hypertension in association to the lifestyle and diet recommendations and may delay the prescription of antihypertensive drugs.
Kamineni Institute of Medical Sciences (KIMS), India
Title: Infant and Young Child Feeding (IYCF) practices and Nutritional Status of Under 5 year Children of Chenchu Primitive Tribe in India
Time : 16:20-16:50
Nikhil Kumar Kotla, MBBS, has graduated from Kamineni Institute of Medical Sciences, Telangana, India in February (2017). He is passionate about research which enhances human wellbeing. He also has clinical experience in the United States of America. He has published one research article in an international journal. He is interested in pursuing his career in the field of Diagnostic Medicine and Clinical Research.
Background: The Chenchus are primitive tribe; a designated Scheduled Tribe in India. They inhabit in the Nallamala forest hilly areas spread in both Andhra Pradesh and Telangana States. They are an aboriginal tribe whose traditional way of life has been based on hunting and gathering. They are a Proto-Australoid tribe and depend on forest produce for their livelihood and both men and women participate in hunting. Similarly, they had distinct socio-culture habits, food habits and food taboos. Appropriate infant and young child feeding (IYCF) practices are pre-requisite for optimal growth and development of the children and inappropriate feeding practices are significantly associated with children under 5 mortality.
Objective: To study the IYCF practices and nutritional status of under 5 year children of Chenchu primitive tribe.
Materials & Methods: A community based cross-sectional study was carried out among 422 Chenchu children less than 5 years of age. Information on socio-demographic particulars and IYCF practices was collected. Weight and height of the children were measured. Appropriate descriptive statistics were performed using SPSS version 19.0. The association between the IYCF practices and nutritional status of children was assessed using chi-square test. The p-value of <0.05 is considered as statistically significant.
Results: About 67% of the mothers initiated breast feeding to their new-born within one hour of the delivery and a majority (92%) of mothers fed colostrum to the infants. The proportion of mothers fed exclusive breast feeding for the first 6 months was 50.2% and about 58% of mothers initiated complementary food to their infant by completion of 6 months. In general, the prevalence of underweight, stunting and wasting among under 5 year children was 42.1%, 56.1% and 16.7%, respectively and no significant difference was found between genders. Though statistically not significant, the prevalence of under nutrition was relatively lower among children exclusively breast fed for the first six months of age (p>0.05). While, a significantly lower prevalence of stunting (p<0.001) and wasting (p<0.05) was reported among those children initiated with complementary feeding at appropriate time i.e. immediately after completion of first six months of age.
Conclusions: In general, the IYCF practices are poor among the mothers of Chenchu primitive tribe, where only about half of the mothers exclusively breast fed their infants and initiated complementary food at an appropriate time. These inappropriate IYCF practices were reflected in poor nutritional status of under 5 year children. Therefore, health and nutrition education (HNE) should be imparted to the mothers through the IEC activities and behavioural change communication (BCC) to adopt the appropriate IYCF practices.
Chinese University of Hong Kong, Shatin, NT, Hong Kong, China
Time : 16:50-17:20
Zhen-Yu CHEN is professor and Head of Graduate Division, School of Life Sciences, Chinese University of Hong Kong. Chen’s research focuses on bioactivity of nutraceuticals, functional foods, fatty acids and cholesterol. Chen is the fellow of American Chemical Society-Division of Agricultural and Food Chemistry, and Royal Society of Chemistry. Chen received his Ph.D degree in 1989 from University of Massachusetts at Amherst. Chen has published more than 230 original scientific papers. Chen is currently associate editor of Journal of Agricultural and Food Chemistry. He is member of editorial boards including Journal of Functional Foods, Biomedical and Environmental Sciences, and Food & Function. Chen has received several awards including the Advancement of Application of Agricultural and Food Chemistry Award by American Chemical Society, High Education Outstanding Scientific Research Output Award by Ministry of Education of China, and Research Excellence Award by The Chinese University of Hong Kong.
Cholesterol is always an important issue because plasma total cholesterol (TC) and low-density lipoprotein (LDL) correlate strongly with the risk of coronary heart disease. Cholesterol homeostasis is maintained by a complex mechanism which involves the sterol absorption, anabolism, catabolism and excretion. Nutraceuticals and functional foods which lower plasma TC can affect the genes which regulate cholesterol homeostasis. In general, cholesterol-lowering functional foods and nutraceuticals can be classified into seven types namely intestinal Niemann-Pick C1 like 1 (NPC1L1) competitors, intestinal acyl-CoA: cholesterol acyltransferase 2 (ACAT2) inhibitors, 3-hydroxy-3-methylglutaryl (HMG-CoA) reductase inhibitors, LDL receptor up-regulators, bile acid reabsorption inhibitors, cholesterol-7α-hydroxylase (CYP7A1) activators, and plasma cholesteryl ester transporting protein (CETP) inhibitors. This presentation will summarize our research, discuss recent research progress in the field, and explore the underlying mechanisms of these popular cholesterol-lowering nutraceuticals and functional foods.
Dr Theodora Mantzourani BSc, MD, MRCGP, MSc, DipNutMed is a GP Specialist in Endocrinology & Diabetes, Nutritional and Preventive Medicine. She is an expert in bioidentical hormones and their use in wellbeing, antiaging and cosmeceuticals. She has a special interest in obesity and obesity-related disease such as insulin resistance and metabolic syndrome. She is an international speaker and a member of IFM and AAFARM. Scientific research: Reproductive Endocrinology. Her clinic is in London.
All dietary carbohydrates are converted into glucose after digestion. Carbohydrate digestion and absorption is a multistage process involving enzymes and transporter proteins. High Glycemic index (GI) carbohydrates are broken down fast during digestion and release glucose rapidly into the bloodstream; low GI carbohydrates are broken down more slowly and release glucose more gradually. High intake of carbohydrates especially those with high GI together with environmental factors contributes to obesity, metabolic syndrome and diabetes.
A new product (Tribitor®) was developed during animal and human studies. During OGTT animal studies performed in rats, different plant extracts were tested for their hypoglycemic effects and after performed comparisons, the plant extracts with the highest hypoglycemic capacities were included into combinations tested for best synergistic hypoglycemic effect. The combination of three extracts with the greatest ability to lower postprandial glycaemia was chosen for further testing in humans. Two randomized, double- blind, placebo controlled studies were performed to GCP standards to verify the hypoglycemic effects of Tribitor®. The effects of this preparation on blood glycaemia were monitored after consumption of different meals. Statistically significant reductions of glucose and insulin peak levels were observed, particularly during the first phase of the test. Reactive hypoglycemia events were observed significantly less frequently when Tribitor® was given before meals. It was also found in a follow-up study, that Tribitor® had the ability to lower the Glycemic Index of white bread.
In summary, Tribitor® is an innovative, patent-pending carbohydrate-blocking technology containing an optimum complex of three standardized plant extracts. Its clinically proven three-phase action reduces glucose and insulin peaks which, in turn, helps reduce the risk of obesity, insulin resistance and reactive hypoglycemia.
University of Sydney, Australia
Vasant Hirani is a Senior Lecturer in the School of Life and Environmental Sciences, University of Sydney. She is a qualified Dietitian, Nutritional Epidemiologist and Public Health Nutritionist, with a PhD in Nutritional Epidemiology. Her primary research interests are focused on the area of ageing research including vitamin D epidemiology and the impact of vitamin D status on healthy ageing. Other research interests are in the field of population health and nutrition, including obesity, chronic disease, anthropometry such as demi-span, and mental health.
Statement of the Problem: Low vitamin D status and sarcopenia are important public health issues among older people due to their adverse impact on morbidity and mortality. A better understanding of the influence of vitamin D metabolites on muscle mass and strength is important clinically. The aims are explore the associations between serum 25-hydroxyvitamin D (25D) and 1,25-dihydroxyvitamin D (1,25D) levels at baseline and incidence of sarcopenia over time in older Australian community-dwelling older men. Methodology & Theoretical Orientation: Men aged ≥70 years (2005-07) from the Concord Health and Ageing in Men Project were assessed at baseline (n=1705), two (n=1366) and five years (n=954). The main outcome measurement was the incidence of sarcopenia defined as appendicular lean mass adjusted for body mass index <0.789 and grip strength <26.0 kg. Serum 25D and 1,25D levels were measured at baseline by radioimmunoassay (Diasorin, Stillwater, MN, USA) and categorised into quartiles as predictor variables. Covariates included age, income, season of blood collection, physical activity, vitamin D supplement and medication use, measures of health, serum parathyroid hormone (PTH), and estimated glomerular filtration rate (eGFR). Findings: The incidence of sarcopenia was 9.2 % in the men at the 2-year follow-up and 14.1% at the 5-year follow-up. Vitamin D levels in the lowest quartiles (25D<40nmol/l; 1,25D<62 pmol/l) were independently associated with the incidence of sarcopenia over 5 years after adjustment for potential confounders and covariates of clinical significance (25D: OR 2.52 (95% CI 1.13, 5.62) p=0.02; 1,25D: OR 2.70 (95%CI 1.29, 5.67) p=0.01). Conclusion & Significance: Low serum 1,25D and 25D concentrations at baseline are independently associated with the incidence of sarcopenia over the subsequent five years. Although our data do not prove any causal relationship, it is conceivable that maintaining vitamin D sufficiency may reduce the incidence of sarcopenia in ageing men.
Dankook University, Korea
The research field of Dr. So-Young Park is natural product chemistry and development of functional food. She holds several patents regarding natural substances having potentials as anti-Alzheimer’s agents. She has worked on to discover natural products which inhibit beta-amyloid production or aggregation, and neuroinflammation. In addition, she expended her research interest to search natural products beneficial for osteoporosis and osteoarthritis.
The advancement of medicine has increased life expectancy, but people are more interested in extending healthy life instead of living unhealthy long life. Ageing increases the incidence of geriatric diseases including cardiovascular diseases, dementia, cataract and osteoarthritis. Among the diseases, bone-related disorders including fracture and osteoporosis affect adversely in the quality of life for old people. Therefore, it is necessary to develop natural substances promoting bone-health without side effects which could be used as food itself or functional food. In this study, we selected 13 natural resources, extracted them with 70% ethanol and boiling water (26 extracts), and tested them for the promoting effects on pre-osteoblastic cell (MC3T3-E1) differentiation using Alkaline Phosphatase (ALP) assay. As the results, 4 extracts from grapes, ginseng, cranberry and roasted peanuts significantly increased the differentiation of pre-osteoblastic MC3T3-E1 cells in APL assay. Particularly, roasted peanuts exhibited the best activity on the differentiation of MC3T3-E1 cells. The roasted peanut extract was partitioned based on solvent polarity to n-hexane, dichloromethane, ethyl acetate and water fractions, and these fractions were also applied to ALP assay. Ethyl acetate fraction the most efficiently induced the differentiation of MC3T3-E1 cells. Then, in order to figure out whether the one of the active compounds included in roasted peanuts is resveratrol, the presence of resveratrol in roasted peanuts were determined by TLC and HPLC. The results revealed that the active compounds in roasted peanuts were not resveratrol. Taken together, roasted peanuts might be beneficial for bone-health by promoting osteoblastic differentiation. Thus, the identification of active compounds other than resveratrol is under investigation. Furthermore, beneficial effects of roasted peanuts on osteoporosis is also under investigation with ovariectomized in vivo animal model.
Temasek Polytechnic, Singapore
Dr Kalpana Bhaskaran is the Domain Lead, Applied Nutrition and Head, Glycemic Index Research Unit at Temasek Polytechnic, Singapore. She championed the design, planning and implementation of Singapore’s and the region’s first accredited Glycemic Index Research Unit (GIRU). She is a qualified Nutritionist/Dietitian w ith more than 20 years of experience in nutrition research, lecturing, project management and consultancy services. She was aw arded the inaugural “Teaching Excellence Aw ard” f or outstanding lecturing, and pedagogy in 2009 and National Day President’s aw ard for Education in 2014. She regularly acts as a nutrition consultant to local and overseas food companies. She is currently the collaborator f or the study on “Investigation of prevalence, burden and risk f ac tors of obesity in schizophrenics”. She is also the Principal Investigator f or f our ongoing clinical trials in the area of Applied Nutrition. Sh e is the Spokesperson f or the Singapore Nutrition & Dietetics Association and the Vice-President of the Diabetes Society of Singapore.
atement of the Problem: As the rate of obesity increases in Singapore, f rom 6.9% in 2004 to 10.8% in the recent National Health Survey, the message and ef f orts f or obesity prevention needs to be targeted at the younger generation. From Singapore’s National Nutrition Survey 2010, skipping breakf ast and having meals aw ay f rom home w ere identif ied as potential risk f actors f or higher BMI observed in the population. The health status of children and adolescents are normally associated to their dietary practices and lif estyle habits. Hence, this study is the first in Singapore w hich aims to look at breakf ast consumption habits, supplement intake and physical activity habits among children and adolescents aged 6 to 17 years old in Singapore. Methodology & Theoretical Orientation: The study w as conducted among 500 Singapore residents aged betw een 6 to 17 years old. Multistage sampling method based on ethnicity, age category and gender w as used. Subjects betw een 6 to 12 years old w ere categorised as “children” and 13 to 17 years old w ere considered “adolescents”.
A survey questionnaire w as designed to capture inf ormation on demographic prof ile, socioeconomic data, breakf ast habits, supplement intake and physical activity among other inf ormation. Findings: Adolescents did not consume breakf ast as regular ly as compared to children. Only 22% of 10 to 11 years aged schoolc hildren consumed breakf ast on a daily basis. This could be supported by the observation that a substantial number of them consumed breakf ast on-to-go. Signif icantly more adolescents reported not f eeling any dif f erence despite not consuming breakf ast. Thirty-nine per cent (39.0%) of the children w ere supplement users and Vitamin C w as the most commonly consumed supplement. Based on a weekly average, adolescents exercised longer (49 minutes) as compared to children (44 minutes). Conclusion & Signif icance: Breakf ast consumption habit w as not associated w ith gender or ethnicity in this study, but signif icantly associated w ith age group. Children consumed breakf ast more regularly than adolescents. There w as no signif icant association betw een BMI categories w ith breakf ast consumption habits among adolescents. How ever, among the children, more skippers than regular breakf ast eaters w ere “overw eight/severely overweight”. The amount of time children and adolescents spent on physical activity w as still below the recommendation by the Health Promotion Board of Singapore.
Neyshabur University of Medical Sciences, Iran
Saeed Samarghandian got Ph.D (NeuroPhysiology, Japan (Tokyo) 2002), and Post-doc (Molecular Medicine, Japan, Tokyo, 2005). He has his expertise in evaluation of Nutrition and diseases (Diabetes, aging and cancer). He also focused on the involved mechanisms of diseases.
Carnosol (CS) is an ortho-diphenolic diterpene in rosemary with great antioxidant potential. This study was designed to investigate the hypolipidemic, anti-oxidant, and anti-diabetic activities of CS. In our experiment, the rats were divided into the following groups of 8 animals each: control, untreated diabetic, three CS (1, 5, 10 mg/kg/day)-treated diabetic groups. On the first day of the study, the diabetic groups were given streptozotocin (STZ) in a single intraperitoneal (i.p.) injection at a dose of 60 mg/kg for induction of diabetes. CS was injected (i.p.) to the treatment groups from 3 days after STZ administration during a period of 4 weeks. At the end of the experimental period, we assessed the serum levels of glucose, IL-6, TNF-α, malondialdehyde (MDA), glutathione–s transfrase (GST), superoxide dismutase (SOD), catalase (CAT) activities, triglycerides (TG), total cholesterol (TC), low density lipoprotein (LDL-C), and high density lipoprotein (HDL-C). The results indicated that STZ caused an elevation of serum glucose, IL-6, TNF-α, MDA, TG, TC, LDL-C, and it also made a reduction of serum GST, SOD, CAT, and HDL-C (p<0.001). The findings showed amelioration in the serum glucose, IL-6, TNF-α, MDA, TG, TC, LDL-C, GST, SOD, CAT, and HDL-C in the CS-treated diabetic groups versus the untreated group, in a dose dependent manner (p < 0.001). In conclusion, the present investigation proposes that CS may be improved diabetes and its complications by modulation of oxidative stress and inflammatory responses.
Korea Food Research Institute, Republic of Korea
Jin-Taek Hwang is a scientist in the field of functional food research. He received his Ph.D. in biochemistry and molecular biology from Kyung Hee University. He is currently working in the Korea Food Research Institute. Current efforts are focused on identifying the active compounds against metabolic syndrome. Dr. Hwang is also interested in the study of nutritional epigenetics.
In the present study, we evaluated the anti-obesity effect of Anacardic acid, a phenolic lipid found in cashew nut (Anacardium occidentale) and elucidated the underlying mechanisms focused on the epigenetic enzymes. We sought to investigate the effect of Anacardic acid on 3T3-L1 adipocyte differentiation. Oil-red O staining revealed that Anacardic acid reduced MDI-stimulated lipid accumulation in 3T3-L1 cells, in the absence of observable cytotoxicity. Western blot analysis showed that Fatty acid synthase (FAS) and Peroxisome proliferator activated receptor gamma (PPARg) expressions were significantly increased by 7 days in MDI-stimulated 3T3-L1 cells, whereas treatment of Anacardic acid markedly decreased the MDI-stimulated FAS and PPARg expressions. In addition, total lysine acetylations were significantly enhanced in MDI-stimulated 3T3-L1 cells, and were decreased by Anacardic acid. Interestingly, histone H3K9 acetylation, an epigenetic modification marker was significantly increased by 7 days in MDI-stimulated 3T3-L1 cells, whereas treatment of Anacardic acid markedly decreased the MDI-stimulated Histone H3K9 acetylation. Taken together, these results suggest that Anacardic acid inhibits the MDI-stimulated adipocyte differentiation in 3T3-L1, and may involve the targeting of histone H3K 9 acetylation.
Diabetic Care Team, Jordan
Rana Mousa Al-Z'ubi has more than twelve years of experience as Registered Dietitian. She is working as a part of Diabetic Care Team and involved in providing dietary health recommendations and interventions as a specialist in dietetics. She worked extensively in translating the science of nutrition into everyday understandable information. She is committed to develop individualized healthcare plans that improve health, prevent disease, and enhance overall physical wellbeing for life.
To measure the abdominal subcutaneous fat (SF) and visceral fat (VF) volumes using high-field magnetic resonance imaging (MRI) and to investigate their association with selected anthropometric and biochemical parameters among obese and non-obese apparently healthy participants. A cross-sectional study was conducted by recruiting 167 healthy participants. Abdominal scans were acquired at 3T MRI, and the SF and VF were segmented and their volumes were calculated. Selected anthropometric and biochemical measurements were also determined. A significant difference (P < 0.05) was observed between normal body weight and overweight and obese participants for SF and VF, total abdominal fat volumes, leptin, resistin, adiponectin and waist circumference. Waist circumferences were measured by tape and MRI. Findings revealed that MRI-measured fat volumes were different between males and females and had a significant (P < 0.01) strong positive correlation with body mass index, leptin, resistin and WC and had a negative correlation with adiponectin level. MRI-measured fat volumes were found to correlate moderately with interleukin-6 and weakly with cholesterol, serum triglyceride and low-density lipoprotein. Except for cholesterol, all measured biochemical variables and abdominal fat volumes in the current study were significantly associated with body mass index. All anthropometric and biochemical parameters showed weak-to-strong associations with the MRI-measured fat volumes. Abdominal fat distribution was different between males and females and their correlations with some lipid profiles were found to be sex dependent. These findings revealed that MRI can be used as an alternative tool for obesity assessment.
Tehran University of Medical Sciences, Iran
Davoud Shojaeizadeh is full Professor of health education and health promotion. He is faculty member of school of public health , Tehran University of Medical Sciences. He is teaching health education, health promotion , health communication and healthy behavior psychology. He has published more than 30 books and more than 50 articles.
Background: Nutrition and medical care prevents the incidence and increase of complications in patients with diabetes. There are controversial believes about the effect of education on the knowledge, attitude and practice of patients with type 2 diabetes. This study aimed to assess the effectiveness of education on knowledge, attitude and nutritional behavior of type m2 diabetic patients.
Methods: In an interventional study, 80 patients with type 2 diabetes were selected from the Tehran clinic, Iran and allocated randomly in two intervention and control groups. Data collection was conducted before and 3 months after the intervention using a questionnaire including two sections: demographic information and questions assessing the knowledge, attitude and nutritional behavior. The intervention was nutritional care education during two group discussion-based session in 30 minutes and by a two week interval.
Results: After the educational program, knowledge increased significantly in both intervention and control groups which was probably due to the routine education program in that center. But significant increase in attitude and behavior was only observed in the intervention group.
Conclusion: Appropriate educational programs should be performed in type 2 diabetes clinics to promote attitude and behavior as well as knowledge of patients.
Federal University of Goiás, Brazil
Ana Gabriella Pereira Alves is a nutritionist graduated from the Federal University of Goiás, Brazil. Completed master’s degree in Health Sciences (Faculty of Medicine/Federal University of Goiás, Brazil) and is currently a PhD student in the same program. Concluded a postgraduate in Sports Nutrition and is a postgraduate student in Functional Clinical Nutrition. Co-author of two book chapters, related to Sports Nutrition, and is anthropometrist ISAK Level 1. Member of the Laboratory of Physiology, Nutrition and Health (Faculty of Physical Education and Dance/Federal University of Goiás, Brazil).
Statement of the problem: Obesity, especially abdominal, is one of the major public health problems in the world. In this regard, studies have observed protective effects of some nutrients on obesity, including calcium, due to its supposed action in the regulation of lipid metabolism in adipocytes. The aim of this study was to evaluate the association between calcium intake and abdominal obesity in Brazilian adults. Methodology: this cross- sectional study was developed in March 2016 with 31
subjects from Santo Antônio de Goiás, Central-West region of Brazil. The waist circumference (WC) was measured with anthropometric inextensible tape (Sanny®, São Paulo, Brazil) at the midpoint between the lowest rib and the iliac crest. Women with WC ≥ 80cm and men with WC ≥ 94cm were classified with increased WC. To obtain average calcium intake, three 24-hour dietary recalls were collected on non-consecutive days, including one day of the weekend. Student’s t-test for independent samples was used to evaluate the difference in calcium intake between adults with adequate and increased WC. Binary logistic regression was used to analyze the association between WC and calcium intake. P values <0.05 were considered significant. This research was approved by the Research Ethics Committee of Federal University of Goiás, Brazil. Findings: Of the 31 participants, 96.8% were female and the mean age was 41.39 (± 11,36) years. There was a higher calcium intake among subjects with adequate WC (p = 0.002) (Table 1). In addition, the lower is the calcium intake, higher is the chance of having increased WC (p= 0.022) (Table 2). Conclusion: Considering the association between calcium intake and waist circumference, the consumption of foods rich in this mineral needs to be encouraged, which may contribute to reduce public health problems like obesity and associated morbidities.