Day 3 :
- Nutrition- Health and Choice | Nutrient related Chronic diseases | Vitaminology & Lipidology | Paediatric Nutrition | Food & Nutritional Toxicology | Diet in Obesity and Underweight
National Nutrition and Food Technology Research Institute, Iran
CESPU University, Portugal
Time : 09:30-10:00
Roni Lara Moya has done his studies in Biomedicine from the University of Mogi das Cruzes, Sao Paulo. He has done his specialization in Anti-Aging Medicine from Seville University, Spain. He completed his Master of Science in Molecular and Cellular Immunology and Biology from the University of Coimbra, Portugal and Master of Science in Clinical Advanced Nutrition from the University of Barcelona, Spain. He did his PhD in Biomedicine and Immunology from the Gulbenkian Institute of Science and Coimbra University. He is the Coordinator of Orthomolecular Medicine of ReGenera Research Group for Aging Intervention. He is the Professor and Director of the Graduation Program in Orthomolecular Therapy-CESPU University, Portugal. He is the Scientific Advisor for Nutraceuticals and Cell Therapy Companies in Europe
One of the main health problems of the contemporary life and a mandatory concern to all anti-aging physicians is the outcome of the constant contact with the high level of intoxication, which can be connected to the widest range of diseases, from allergies till cancer or neurodegeneration. Discussion of the physiological pathways for detoxification has been mainly centered around phase I and phase II enzyme systems. Some key nutrients and antioxidants substances, which can inhibit the oxidation of a molecule and have the capacity to nullify the ill effects of oxidation caused by free radicals in the living organisms, have been and continue to be investigated for their role in the modulation of metabolic pathways involved in detoxification processes. Superoxide dismutase (SOD), glutathione peroxidase (GPX) and catalase are the key enzymatic antioxidants of this defense system by which the free radicals that are produced during metabolic reactions are removed. Several publications to date have leveraged cell, animal, and clinical studies to demonstrate that within the correct dose and synergy, food-derived components and nutrients can function as important co-factors to modulate processes of conversion and excretion of toxins from the body. The “Phase I” cytochrome P450 superfamily of enzymes (CYP450) is generally the first defense employed by the body to bio transform xenobiotics, steroid hormones, and pharmaceuticals. These microsomal membrane-bound, heme-thiolate proteins, located mainly in the liver, but also in enterocytes, kidneys, lung, and even the brain, are responsible for the oxidation, peroxidation, and reduction of several endogenous and exogenous substrates. It is accepted that any variability in the number of CYP450 enzymes could have benefit(s) and/or consequence(s) for how some individual responds to the effect(s) of (a) toxin(s). Many nutrients appear to act as both inducers and inhibitors of CYP1 enzyme. These findings indicate that specific foods, vitamins, minerals, enzymes, etc., may upregulate or favorably balance metabolic pathways to assist with toxin biotransformation and subsequent elimination. Various foods such as cruciferous vegetables, berries, soy, garlic, turmeric and other spices, plus probiotics and exogenous antioxidants such as vitamins C, E, B complex, glutathione, cysteine, taurine, methionine, L-carnitine, CoQ10, etc., have been suggested to be beneficial and commonly prescribed as part of the orthomolecular and functional medicine-based therapies. The objective of this talk is to highlight the clinical effect of the orthomolecular nutrients in the detoxification mechanisms. Enhance the knowledge about the main antioxidants, foods, and their individual phytonutrients, especially in the case of dietary supplements and functional foods, could be worthwhile for clinicians to consider for patients who are taking a polypharmacy approach or are in contact with pollution by-products, heavy metals, hormones and further xenobiotics.
National Nutrition and Food Technology Research Institute, Iran
Title: Whether probiotic supplementation is effective in prevention of the hyperglycemia induced maternal hypertension?
Time : 10:00-10:30
Hajifaraji Majid is a Research Associate Professor in Nutritional Sciences of the National Nutrition and Food Technology Research Institute (NNFTRI), and has been served as Dean of Faculty of Nutritional Sciences and Food Technology (FNSFT) from 2010- 2015 and President of Iranian Nutrition Society (INS) from 2011-2015. He has a PhD in clinical nutrition program at Kings College, London University.
Despite achieved progress in the control and treatment of pregnant women with gestational diabetes mellitus (GDM), these patients are still at risk of disease complications. The aim of present study was to investigate the effect of probiotic supplement on systolic blood pressure (SBP) and diastolic blood pressure (DBP) among GDM pregnant women.
In this randomized double-blind, placebo-controlled trial 64 pregnant women with GDM were assigned into two groups and received probiotic capsule (n=32) or placebo (n=32) for 8 weeks. Blood pressures were measured at baseline and 2 weeks intervals and up to 8 weeks.
56 subjects were analyzed at the end of the study. After 8 weeks, SBP didn’t differ significantly in probiotic group at any time checkpoint but increased significantly in placebo group. DBP changes in a trend in probiotic group was obvious after 2 weeks and was reducing towards, however in placebo group, there was a tendency for higher DBP after week 6. There were significant differences between two groups of study after 6 weeks in the terms of SBP[104.828 (2.051) mmHg vs. 112.963 (2.126) mmHg , p=0.008 and 106.552(1.845)mmHg vs. 115.185(1.912)mmHg, p=0.002, in weeks 6 and 8 respectively] and DBP [62.414 (1.353) mmHg vs. 70.741 (1.402) mmHg , p<0.001and 60.690 (1.540)mmHg vs. 71.296 (1.596)mmHg, p< 0.001, in weeks 6 and 8 respectively].
Conclusion: The results demonstrated that taking probiotic supplements for 8 weeks in patients with GDM prevented the increase of SBP and resulted in reduction of DBP after 2 weeks of consumption.
Time : 10:30-11:00
Yi-Cheng Hou beening detention since June 2007 in Taipei Tzu Chi Hospital. So far, in the clinical business in the deep understanding of pre-diabetes and diabetes patients have an increasing trend for the active intervention of this group of patients become urgent of the subject. Diabetes and pre-diabetes in addition to blood sugar than the average person, the nutritional intake and diet behavior correction, intestinal function has begun to occur lesions, and even whether the brain structure has begun to change, need to be strictly monitored. Therefore, Hou dietitian research is mainly for pre-diabetes and diabetes patients with the above objectives of the intervention. During the working period, two papers have been published in the domestic society, ten international papers, one from SCI original papers and international journals SCI papers.
The functional connectivity of diabetes can help us explain the brain function decline in hyperglycemic status. However, the issue has not been addressed much in prediabetes. Therefore, we designed this study to investigate the inter-hemispheric coordination in the prediabetes. Sixty-four prediabetic patients and fifty-four controls were enrolled in this protocol. They received the structural and resting-state functional magnetic resonance imaging screen. The imaging data were preprocessed and analyzed to obtain voxel-mirrored homotopic connectivity (VMHC), which can measure inter-hemispheric coordination. The VMHC values were compared between two groups with age and gender as covariates. The controls had higher VMHC values than prediabetic patients in bilateral anterior cingulate cortex. The prediabetic patients had higher VMHC values than controls in bilateral middle frontal gyrus. The VMHC values were also negatively correlated with pre-prandial serum glucose level in inferior frontal gyrus of prediabetic patients. In addition, the VMHC values of prediabetic patients were negatively correlated with total carbohydrate and calorie intake in anterior cingulate cortex. The inter-hemispheric coordination in anterior sub-network of default mode network and fronto-cingulate regions would play a role in the pathophysiology of prediabetes. The diet impact on the inter-hemispheric coordination is also an interesting issue.
Young Researchers Forum
Ankara University, Turkey
Time : 11:20-11:40
Çaglar Akçalı has completed her Bachelor of Nutrition and Dietetic from Ege University. She is doing her Master’s degree in Department of Nutrition and Dietetic at Ankara Univesity. Also, she is a Research Assistant at the same university.
Essential subject taking place within the education process of students of nutrition and dietetics who are responsible for the regulation of nutrition of whole society and trainings in this issue is on bodily use of nutritional elements and disease relations. The aim of this study is to figure out to what extent effects of micronutrients on nutrition and human health is known by especially students of nutrition and dietetics who lead the society in terms of nutrition. This study has been conducted with 168 (157 females and 11 males) undergraduate students in 3th and 4th grade of Department of Nutrition and Dietetics of two universities. In the study, micronutrient knowledge of students has been investigated. A questionnaire form with 33 questions has been used in the study. 1 and 0 points have been given to each true, false and neutral responses respectively. In total, minimum 0 and maximum 33 points can be obtained. In all statistical tests, significance level has been accepted as p <0.05. Any significant difference has not been found between average knowledge points and gender, age, grade and university (p >0.05). It has been figured out that average knowledge point of students is 19. This study has an importance in terms of determining the knowledge level of students of nutrition and dietetics who have a vital role in protection of community health about micronutrient resources, its recommended doses, health problems as a result of inadequate or high intakes. As a result of the study, knowledge level of the ones who have taken education in this issue is moderate. Following the current guides may be helpful for the students to keep their knowledge updated.
Ankara University, Turkey
Time : 11:40-12:00
Semsi Gul Yilmaz was born on February 6, 1993, in Konya, Turkey. In 2014, she has completed from Gazi University’s Department of Nutrition and Dietetics in Ankara after graduating from primary school and high school in Konya. She is doing her Master's degree in Department of Nutrition and Dietetics at Ankara University in 2015. Also, she is a Research Assistant at the same university. She is interested in obesity, nutrigenetics, nutrigenomics, genotoxicity
Statement of the Problem: The prevalence of obesity has reached very serious dimensions and continues to increase day by day. Most of the studies aimed at obesity consist of physiological and biochemical clinical studies. However, obesity is not only a psychological and physiological aspect, but also an important health problem that should be addressed by social aspects due to discriminatory or stigmatizing and prejudiced behaviors of obese individuals against others in the society. The purpose of this study is to determine the body perception and obesity prejudice in university students.
Methodology & Theoretical Orientation: The study was conducted on 607 university students (465 female and 142 male) in Ankara. The GAMS-27 Obesity Prejudice Scale was used to assess the prevalence of obesity and to be focused on the views of participants about obese individuals, their health status, and their social relationships. The significance level in all statistical tests was accepted as p<0.05.
Findings: The mean body mass index (BMI) of male was 23.6±3.02 kg/m2 while female was 21.4±2.72 kg/m2. The rate of participation in the negative statement about body perception and obesity prejudice in the prejudiced group was found to be higher than the unprejudiced group. Numerical differences between those who were prejudiced and unprejudiced were statistically significant.
Conclusion & Significance: Many individuals think that they are not prejudiced against obese individuals, but there are prejudices that they are not aware of it. Although most participants state that they are not prejudiced against obese individuals, it is clear that the result is prejudiced or prone to bias. Obesity prejudice and body perception disturbance are a very important problem today. In order to determine the necessary policies for resolving these problems, it is necessary to carry out more comprehensive studies on the causes and the influences of these situations.
Federal University of Goiás, Brazil
Time : 12:00-12:20
Ana Gabriella Pereira Alves is a Nutritionist graduated from the Federal University of Goiás, Brazil. C er’s degree in Health Sciences (Faculty of Medicine/Federal University of Goiás, Brazil) and is currently a PhD student in the same program. She concluded a postgraduate in Sports Nutrition and is a postgraduate student in Functional Clinical Nutrition, co-author of two book chapters, related to Sports Nutrition, and is Anthropometrist ISAK Level 1. She is also a Member of the Laboratory of Physiology, Nutrition and Health (Faculty of Physical Education and Dance/Federal University of Goiás, Brazil).
Statement of the Problem: Overweight is a worldwide public health problem, including in Brazil, and fruits and vegetables consumption is a way to prevent it. In relation to vitamin C, found mainly in fruits and vegetables, its consumption contributes to the reduction of the inflammatory process associated with overweight. The aim of this study was to evaluate the relationship between vitamin C intake and obesity in Brazilian adults.
Methodology: This cross-sectional study was developed in approved by the Research Ethics Committee of Federal University of Goiás, Brazil. The body fat percentage was measured by bioelectrical impedance analysis and the subjects were classified as obese and non-obese. For the assessment of the adequacy of vitamin C intake, were collected 24-hour dietary recalls in three non-consecutive days, including one day of the weekend, considering the average intake. Pearson’s chi-square test was used to compare the prevalence of low vitamin C intake between obese and non-obese. Binary logistic regression was used to analyze the association between obesity and vitamin C intake. P values <0.05 were considered significant.
Findings: Of the 31 participants, 96.8% were female and the mean age was 41.39 (±11,36) years. There was a greater prevalence of low vitamin C intake among obese adults (p=0.006) (Table 1), and the low intake of vitamin C increased the chance of being obesity (OR=0.060, p= 0.028) (Table 2).
Conclusion: The consumption of foods rich in vitamin C should be encouraged among the assessed obese adults, improving the intake of foods with lower energy density and higher antioxidante status, which consenquently will prevent future health problems.
University of Nairobi, Kenya
Title: Overweight in Children: An Unexpected Outcome by Trained Community Health Workers in a Rural Setting in Kisumu County, Kenya
Time : 12:20-12:40
Caroline Sawe is a Lecturer at Moi University, Kenya. She teaches Human Nutrition. She is a PhD student at University of Nairobi Kenya in Applied Human Nutrition. She holds a Master’s degree in Public Health (Moi University, Kenya), Bachelors of Sciences degree in Foods Nutrition and Dietetics (Egerton University, Kenya). Prior to joining Moi University, she worked at Moi Teaching and Referral Hospital, Eldoret as a Nutrition Office and an HIV nutrition research project. She believes research is the most important service she can provide to her poor community because it is only opportunity she can help a generation function knowledgeably in a society where rapid technological advances constantly pose new questions and ethical challenges.
Globally an estimated 19 million children are malnourished. The prevalence of child overweight is rising in low income countries and more in the poor rural setting. It is no longer associated with socio economic elite. It predisposes individuals to adulthood obesity, psychological morbidity and is associated with increase in prevalence of non-communicable diseases. This is a public health issue that needs urgent intervention. In several communities, trained Community Health Workers have been used as agents of improving nutritional outcomes and have proved effective. World Vision Kenya trains them on timed target counseling where they visit mothers and give key nutrition messages at specific times during child’s growth. This study assessed the effect of the counseling intervention on nutritional status of 101 children aged below two years in a rural setting in Kenya. The analysis compared nutritional status before and after the intervention. Child weight and height were collected and Weight for Age Z-scores calculated. Mean age of children was 11.84 months, weight 8.6kg, height 70.86cm and 51(50.5%) were females. The prevalence of overweight and severely overweight was 3.79% and 3.01% at baseline and 10.89% and 4.95% (chi= 21.547, p<0.001) respectively at end-line. It is emerging that overweight in young children is a worrying trend and interventions even in poor settings should not ignore over-nutrition. This trend should be tamed before in early years of life so as to avert its negative consequences in later years.
Hacettepe University, Turkey
Time : 12:40-13:00
Gulsum Gizem Topal works as Research Assistant in the Department of Nutrition and Dietetics at Hacettepe University. She holds a Master’s degree on Food Service System. Her Master’s thesis topic is the determination of the aflatoxin M1 levels in different yogurt types in the markets. She wants to continue her academic life with food carcinogens that she is interested in.
Statement of the Problem: Aflatoxin M1 (AFM1) is a major toxic and carcinogenic molecule in milk and milk products. Therefore, it poses a risk for public health. There are some studies that probiotics have a binding ability to AFM1, so that they can remove the AFM1 from yoghurt. The aim of this study is to evaluate the AFM1 binding ability of some probiotic bacteria in phosphate buffer saline.
Methodology & Theoretical Orientation: The PBS samples artificially contaminated with AFM1 at concentration 100 pg/ml were prepared with probiotics bacteria that including monoculture (L. plantarum, B. bifidum ATCC, B. animalis ATCC 27672) and binary culture (L. bulgaricus + S. thermophiles, B. bifidum ATCC + B. animalis ATCC 27672, L. plantarum+B. bifidum ATCC, L. plantarum+ B. animalis ATCC 27672). The samples were incubated at 37°C for 4 hours and stored for 1, 5 and 10 days. The toxin was measured by the ELISA.
Findings: The highest levels of AFM1 binding ability (63.6%) in PBS were detected yoghurt starter bacteria, while L. plantarum had the lowest levels of AFM1 binding ability (35.5%) in PBS. In addition, it was found that there was significant effect of storage on AFM1 binding ability in all groups except the one including B. animalis (p<0.05).
Conclusion & Significance: Results demonstrate that AFM1 detoxification by probiotic bacteria has a potential application to reduce toxin concentrations in yoghurt. Moreover, probiotic strains can react with itself as synergic or antagonist.
Hacettepe University, Turkey
Time : 13:00-13:20
Sumeyra Sevim has gratuated from Department of Nutrient and Dietetics, Hacettepe University in 2013 and Master’s degree in Food Service System at Hacettepe University, then she completed her Master’s degree which is related to AFM1 detoxification by probiotic bacteria in 2016. She is still a PhD student. She wants to work on probiotic bacteria for her PhD thesis.
Statement of the Problem: Aflatoxin M1 (AFM1) represents mutagenic, carcinogenic and immunosuppressive properties, and shows adverse effect on human health. It is emphasized that probiotic bacteria can reduce the level of toxin by AFM1 binding ability in recent studies. Moreover, the studies show that inulin is a prebiotic to improve the ability of probiotic bacteria. Therefore, the aim of the study is to investigate the effect of inulin on AFM1 binding ability of some probiotic bacteria.
Methodology & Theoretical Orientation: Yoghurt samples were manufactured with artificially contaminated skimmed milk powder with 100 pg/ml AFM1. Different samples were prepared using L. bulgaricus and S. thermophilus as yoghurt starter bacteria and L. plantarum, B. bifidum ATCC, B. animalis ATCC 27672 as probiotic bacteria. Moreover, the same work groups were prepared with inulin (4%). The samples were incubated at 42°C for 4 hours, then stored for three different time interval (1, 5 and 10 days). The toxin was measured by the ELISA.
Findings: When inulin was added to work groups, there was significant change AFM1 binding ability at least one sample in all groups except the one with L. plantarum (p<0.05). The highest levels of AFM1 binding ability (68.7%) was found in B. bifidum and inulin added samples, while the lowest levels of AFM1 binding ability (47.2%) was found in B. animalis and inulin added samples. The most impressive effect of inulin was found on B. bifidum. In this study, it was obtained that there was a significant effect of storage on AFM1 binding ability in the all groups with inulin except the one with L. plantarum (p<0.05).
Conclusion & Significance: Results show that AFM1 detoxification by probiotics has a potential application to reduce toxin concentrations in yoghurt. Besides, inulin has different effects on AFM1 binding ability of each probiotic bacteria strain.
Extended Networking Session
Awards & Closing Ceremony