6^th International Conference and Exhibition on Nutrition September 14-16, 2016 Hilton San Antonio Airport
San Antonio, Texas, USA

Biography:

Arpita Basu has completed her PhD in Nutrition from Texas Woman’s University followed by Postdoctoral studies in Clinical Nutrition from the University of California Davis Medical Center. She is an Associate Professor of Nutritional Sciences at Oklahoma State University. She has published more than 40 peer-reviewed reputable journal papers and invited book chapters. Her work in the area of functional foods and dietary bioactive compounds has been widely cited and she serves as an Editorial Board Member of the prestigious Journal of Nutrition.

Abstract:

Cardiovascular disease (CVD) continues to be the leading cause of morbidity and mortality in the global population and much of its etiology has been associated with nutritional factors. Dietary sources of polyphenols especially berries, cocoa and tea have been shown to reduce CVD risk factors in clinical studies and have been associated with reduced risks of diabetes, hypertension and CVD events in large observational cohorts. Our research has demonstrated the effects of green tea, berries and cocoa in improving CVD risk factors especially those related to the metabolic syndrome or pre-diabetes in randomized clinical studies. We reported the role of green tea beverage and supplements in lowering body weight in obese adults with the metabolic syndrome. We also observed significant effects of dietary blueberries and strawberries in lowering blood pressure and blood cholesterol, respectively in obese adults with the metabolic syndrome and elevated serum lipids. These effects were observed in studies ranging from eight to 12 weeks in duration. We also reported acute postprandial effects of cocoa beverage in increasing HDL-cholesterol following a fast food style meal challenge in obese adults with type-2 diabetes. In addition to improving conventional CVD risk factors such as obesity, hypertension and elevated blood cholesterol, berries and green tea were also shown to lower oxidative markers of atherosclerosis such as lipid peroxidation in these at risk individuals in our studies. Our research findings further the understanding of polyphenol-rich foods and beverages in the management of CVD risk factors using dietary achievable doses of berry fruits, cocoa and green tea.

Biography:

Christina Ellervik has completed her MD in 2002 and her PhD in 2007 from University of Copenhagen, Denmark and she was board certified in Clinical Biochemistry in 2009 from National Board of Health, Denmark. She was working as an Associate Professor at University of Copenhagen, Denmark from 2010 to 2015. She is currently a Visiting Scientist at Boston Children’s Hospital and Department of Preventive Medicine, Brigham and Women’s Hospital, Boston, MA, USA. She also the Founder of the Danish General Suburban Population Study (N=21,000) and Co-editor for Clinical Chemistry. She has published more than 50 papers in reputed journals

Abstract:

Previous meta-analyses have shown a reduced risk of ischemic heart disease and type-2 diabetes in individuals consuming dairy products vs. those who do not. We investigated the association between lactase persistence, milk intake and risk of ischemic heart disease and type-2 diabetes in three general population studies of approximately 100,000 adult Danes. We used the genetic variant LCT-13910 C/T (rs4988235) as proxy/surrogate for long-term milk intake in Mendelian randomization studies to assess indirectly whether there may be a causal association between milk intake and risk of ischemic heart disease and type-2 diabetes. The genetic variant LCT-13910 C/T is associated with downregulation of the lactase enzyme activity in adults of European descent, referred to as lactase non-persistence (genotype CC) and lactase persistence (genotypes TC and TT) and affects the ability of adults to digest the lactose in milk. We found no association between milk intake and risk of ischemic heart disease or type-2 diabetes in our observational studies. We found a higher intake of milk among lactase persistent participants (TC/TT) than among lactase non-persistent (CC) corresponding to a difference of approximately 2 glasses per week. However, we found no association between the genetic variant LCT-13910 C/T (proxy/surrogate for milk intake) and risk of ischemic heart disease and type-2 diabetes. The results from our Mendelian randomization studies thus supports the findings from the observational studies. These are important results, as many people, in Denmark as well as worldwide, consume milk

Biography:

Ms Marietta M. Bumanglag, RND, is a Senior Science Research Specialist at the FNRI-DOST, the country’s lead agency in food and nutrition research & development. She obtained her Master of Public Health from the University of Queensland, Australia. Her project involvement includes Recipe development, Recipe/menu evaluation and Development of dietary tools : recipe booklets and Menu Guide Calendars (MGC) since 2004 as senior author. Her publication included the FNRI MGCs, LUTONG FNRI: Brown Rice recipes para sa Lahing Kayumanggi and Mga Katutubong Gulay, Recipe booklet utilizing malunggay leaves powder and yacon tubers, and Nutritious recipes for the FNRI supplementary feeding program

Abstract:

Failure to meet increased demands for energy and nutrients and poor eating habits have long term health, growth and development consequences in adolescents. A calendar to promote consumption of healthier meals in adolescents to help meet their nutrient needs through consumption of legumes and nuts was developed. The following activities were conducted: Focus Group Discussion (FGD) among panelists (n=8) to explore adolescents’ perceptions and insights towards food, eating behavior and food preferences; two (2) recipe trials and sensory evaluation to determine acceptability of recipes based on the Hedonic Rating Scale scores of sensory panelists (n=15; n=50) ; estimation of energy and nutrient content of recipes using the FCT + Menu Eval Software; photo-documentation and formulation of 4-week cycle menus. Themed “Helping meet the nutrient needs of adolescents through consumption of legumes and nuts”, the MGC 2016 highlights 15 recipes consisting of snacks, one-dish meal and viands incorporated in the 4-week cycle menu. The recipes utilized locally available and familiar legumes: green and red mung beans, lima beans, peanuts, white and red kidney/snap beans, pigeon pea and string bean seeds. Other features included articles on legumes and nuts, nutritional needs of teenagers and tips on encouraging teens to eat healthy foods and Pinggang Pinoy for teens, 13-18 years. The calendar may serve as a reference/guide for homemakers/food providers in preparing nutritious and varied meals, and a challenge for adolescents to try new and exciting recipes. The MGC is downloadable in the FNRI website for wider audience reach and dissemination

Biography:

Abstract:

Biography:

TokuÅŸoÄŸlu has completed her PhD at Ege University Engineering Faculty, Dept of Food Engineering at 2001. She is currently working as Associate Professor Dr faculty member in Celal Bayar University Engineering Faculty Department of Food Engineering. TokuÅŸoÄŸlu performed a visiting scholar at the Food Science and Nutrition Department /University of Florida, Gainesville-Florida-USA during 1999-2000 and as visiting professor at the School of Food Science, Washington State University, Pullman, Washington,USA during April-May 2010. She has published many papers in peer reviewed journals and serving as an editorial board member of selected journals. TokuÅŸoÄŸlu published the scientific edited two international book entitled Fruit and Cereal Bioactives: Chemistry, Sources and Applications and entitled Improved Food Quality with Novel Food Processing by CRC Press, Taylor & Francis,USA Publisher, third book Food By-Product Based Functional Food Powders is in progress; Dr Tokusoglu also published two national books entitled Cacao and Chocolate Science and Technology and Special Fruit Olive: Chemistry, Quality and Technology. She organized and/or administered as Conference Chair at many conferences and congress in various parts of USA and Europe.

Abstract:

Innovative frying oil ‘’Spil Innova Fryoil’’ which contain antioxidant, emulsifier and antipolymerizing additive constituents was developed and the quality profiles of improved frying oil and fried food products with above-mentioned oil was evaluated. The physicochemical quality, sensory quality profile, gas chromatography (GC) fatty acid profile, total polar compound, oxidative stability (rancimate) and overall fried food quality of new oil and fried food were performed. It was determined that the total polar compound levels of ‘’Spil Innova Fryoil’’ was stable between 1th-15th (even 10th-15th) frying process. Linoleic acid (C18:2; omega-6) was preserved and no trans acid increasing was found by repetitive fryings; no increased amount of trans-oleic acid (elaidic acid) and trans-linoleic acid (linoleadic acid). It was observed that the used jujube extract additive gave more stability to innovative frying oil; polar compounds of fried potato oils by 5th,10th,15thfrying process and also the fried potato color was stable after repetitive frying

Biography:

Bruce Burnett is an expert in the field of nutritional products development. He is Vice President of Compliance, Regulatory, & Medical Affairs at Entera Health, Inc. Dr. Burnett received his BS degrees in Biology and Chemistry from Eastern Washington University and his Master’s and PhD in biochemistry and biophysics from Yale University. He also received several NIH and SBIR grants, served on the ad hoc study section for review of SBIR awards and acts as a reviewer for several journals around the world. Dr. Burnett has 50 peer-reviewed publications, 2 book chapters, and over 30 peer-reviewed published abstracts

Abstract:

Gastrointestinal Survival of Oral Immunoglobulins Allows for the Management of Gastrointestinal Conditions and Diseases: Oral immunoglobulins have been tested clinically for over 40 years, yet only recently have these agents been used in patients to manage gastrointestinal conditions and diseases. Multiple studies in animals and humans have found that a percentage of these functional proteins survive the harsh gastric environment into the small and large intestines with small amounts remaining active for antigen binding in the feces. There is a structural basis for this phenomenon, which is due to the highly crosslinked, disulfide bond containing nature of antibodies, 3-dimensional folding and post-translational glycosylation. Dozens of studies suggest the utility of these molecules in infectious enteropathy against bacteria, viruses, and protozoa, but they more recently have been tested clinically in irritable bowel syndrome with diarrhea (IBS-D), inflammatory bowel disease (IBD), and HIV-enteropathy. In vitro and in vivo studies demonstrate that a medical food preparation containing serum-derived bovine immunoglobulin/protein isolate (SBI), purified from USDA-approved edible plasma, binds to a wide variety of microbial antigens generated by the cow with exposure feed-lot environments. This protein preparation with over 50% IgG has been shown to safely manage IBS-D, IBD, and HIV-enteropathy by providing for a distinctive nutritional requirement. More likely than not, this occurs through the binding of microbial components (i.e., endotoxins) generated during dysbiotic growth and degredation of microbes in the gut. SBI represents a new type of food-based therapy for the management of chronic conditions and diseases of the intestinal tract

Biography:

Takashi Takeuchi is a Professor of Department of Veterinary Medicine, Tottori University, Japan. His research interest is focused on the novel function of lactoferrin, including intestinal absorption, improvement of liver and kidney failure, anti-stress and anti-nociceptive effect, etc.

Abstract:

Lactoferrin (Lf) is a physiological compound produced by exocrine glands and released at a high concentration in colostrum. It plays numerous biological and beneficial functions. In this study, we investigated a benificial effects of Lf on the chronic kidney disease model induced by 5/6 subtotal nephrectomy rat. Male Wistar rats in 5 weeks old, underwent resection of 2/3 of the left kidney and total excision of the right kidney with an interoperative interval of 1 week (NX rat). The rats were divided into four groups, NX + BSA (300 mg/kg, po), NX+bovien Lf (300 mg/kg, po) and sham+BSA, sham+bLf. Blood and urine samples were collected every 2 weeks, and the blood urea nitrogen (BUN) and creatinine (Cre) were determined up to 12 weeks after the operation. Blood pressure was also measured during the first two weeks. At the 12th week, the rats were sacrificed, then kidney tissue was collected and analysed histopathologycally. In the NX+BSA group, BUN, Cre, urine volume and urinary protein increased time dependently. Blood pressure also incrased at the 3rd day after the operation in NX+BSA rat. In contrast, NX+bLf group showed lower BUN, urinal protein/Cre ratio, and suppressed the increment of blood pressure. Although bLf improved decreasing of glomerular counts, there were no significant differences in interstitial fibrosis and glomerular sclerosis (Masson’s trichrome stain) between NX+BSA and NX+bLf group

Biography:

Osama O Ibrahim is a highly-experienced Principal Research Scientist with particular expertise in the field of microbiology, molecular biology, food safety and bioprocessing for both pharmaceutical and food ingredients. He is knowledgeable in microbial screening, culture improvement; molecular biology and fermentation research for antibiotics, enzymes, therapeutic proteins, organic acids and food flavors; biochemistry for metabolic pathways and enzymes kinetics, enzymes immobilization, bioconversion, and analytical biochemistry. He was an External Research Liaison for Kraft Foods with Universities for research projects related to molecular biology and microbial screening and holds three bioprocessing patents and multiple publications. Upon his retirement from Kraft Foods he formed his own biotechnology company providing technical and marketing consultation for new startup biotechnology and food companies. He has received his BS in Biochemistry with honor and two MS degrees in Microbial Physiology/ Fermentation and in Applied Microbiology. He has received his PhD in Basic Medical Science (Microbiology, Immunology and Molecular biology) from New York Medical College. He is a Member of American Chemical Society, American Society of Microbiology and Society of Industrial Microbiology since 1979

Abstract:

Free sugars refer to monosaccharides such as (glucose, fructose) and disaccharides such as (sucrose, maltose) added to foods and drinks by manufacturer, cook or consumer and sugars naturally present in honey, syrups, fruit juices and fruit juice concentrates’. Reducing free sugars intake to less than 10% of total daily energy uptake was recommended by the WHO (World Health Organization) for the first time in 1989 and was further elaborated by a joint WHO/FAO (Food and Agriculture Organization) expert consultation. This new updated WHO guideline calls for further reduction of free sugars intake to less than 5% of total energy uptake if possible. This guideline is to halt the rise of diabetes and obesity and reduce the burden of premature death due to non-communicable disease (NDCs). It does not refer to sugars in fresh fruits and vegetables and sugars naturally present in milk, because there is no reported evidence of adverse effects of consuming these sugars

Biography:

Alison Burton Shepherd is a Senior Lecturer in Adult Nursing at De Montfort University, UK. In 2010, she became a Queens Nurse, which is an Award given for excellence in Nursing Care within the community setting. She works as an Advanced Nurse Practitioner and she is an Independent Nurse Prescriber. She is also an Inspector for the Care Quality Commission

Abstract:

Chemo-radiotherapy (CRT) causes or exacerbates symptoms, such as alteration or loss of taste, mucositis, xerostomia, fatigue, nausea and vomiting, with consequent worsening of malnutrition. It is well known that radiotherapy is invariably associated with mucositis, xerostomia, dysphagia, haematological toxicities and other acute side effects, whose incidence increases when chemotherapy is also administered, and that oral mucositis incidence leads to higher unplanned breaks and delays in radiotherapy administration. In addition, in many patients such toxicities may be very severe and even life threatening and may lead to treatment interruptions that are invariably associated with poorer outcome. This presentation will review best practice in the nutritional management of patients undergoing chemotherapy and radiotherapy

Biography:

Abstract:

Introduction and purpose of the study Adiponectin (ADPN), adipokine produced by adipose tissue, circulates in several forms, one form of high molecular weight (HMW) is considered to be biologically active. Unlike leptin, ADPN concentrations are lower in obese and / or insulin-resistant patients. Bariatric surgery bypass provides a significant reduction in body fat, improved carbohydrate and lipid parameters and standardization of ADPN concentrations. The long-term surveillance of patients who underwent bariatric surgery has allowed us to observe that there was, in some cases, exaggerated ADPN elevations among patients who had malnutrition with significant hypoalbuminemia. In these circumstances, we quantified the total ADPN (TADPN) and HMW in subjects with hypoalbuminemia and we followed the evolution of ADPN in malnourished patients before and after refeeding. Materials and methods 57 subjects (28 W, 29 M), hospitalized at Pitié-Salpêtrière with hypoalbuminemia were explored. These patients were classified into two groups depending on the concentration of serum albumin: severe hypoalbuminemia <20 g / L (13 W, 22 M) and hypoalbuminemia 20 g / L ≤ AB ≤ 30 g / L (15 W, 7 M). 36 healthy volunteers constitute the control population (20 W, 16 M). We followed 5 patients (4 W, 1 M) who presented hypoalbuminemia after bariatric surgery. The TADPN was assayed by ELISA (ALPCO) and HMW was quantitated by an automated assay (Fujirebio Lumipulse G1200). Results As in controls, the concentrations of TADPN and HMW are higher in women than men among patients with hypoalbuminemia. However, serum concentrations of HMW ant TADPN were significantly higher in subjects with severe hypoalbuminemia whatsoever in men (p = 0.0004) and in women (p = 0.0003) . We were able to demonstrate that there was an inverse correlation between hs-CRP and TADPN and HMW (p = 0.0003 and 0.0002, respectively). Finally, by applying a partial correlation test (by fixing hs-CRP concentrations), there is a significant negative correlation between albumin and TADPN (p = 0.013), albumin and HMW (p = 0.015). Moreover, when hypoalbuminemia is corrected through therapeutic care, we see decreased TADPNT and HMW blood concentrations. Conclusions We show in this work that the values of TADPN and HMW exceed the usual values in patients with hypoalbuminemia but they must be interpreted according to hs-CRP. The concentrations of adiponectin return to normal after hypoalbuminemia correction. While the regulatory mechanisms are still unknown, we propose to evaluate the interest of TADPNT and HMW dosage as a nutritional marker by applying it to a larger population.

Biography:

Habte-Michael Habte-Tsion studied M.Sc. and PhD in Aquaculture (Fish Nutrition) at Nanjing Agricultural University (NAU) in one of the most prestigious universities in China and he received great academic records and achievements (e.g. he has received national and institutional rewards and awards). He has published 1 academic book and 20 original research papers in preeminent peer-reviewed scientific journals. He is also a reviewer in 7 international journals. As a young scientist with an excellent career start, he has great potential for further innovative research task.

Abstract:

The present study conducted a 9-week feeding trial to investigate the effects of threonine (Thr) on the digestion capacity and hepatopancreas gene expression of juvenile blunt snout bream (Megalobrama amblycephala). For this purpose, three tanks (300 litres/tank) were randomly arranged and assigned to each experimental diet. Juvenile fish were fed with diets containing graded Thr levels (0.58, 1.08, 1.58, 2.08 or 2.58% of the diet) to apparent satiation four times daily. At the end of the feeding trial, the results indicated that hepatopancreas weight, hepatosomatic index, hepatopancreatic protein content, intestinal weight, intestosomatic index and intestinal protein content increased with increasing dietary Thr levels up to 1.58% and thereafter decreased (P<0.05). The activities of chymotrypsin, trypsin, amylase and lipase elevated as dietary Thr levels increased up to 1.58% (P<0.05), while these activities decreased in most cases after 1.58% dietary Thr except for chymotrypsin and trypsin in the hepatopancreas (plateau 1.58 – 2.08% Thr). The relative gene expression levels of chymotrypsin, trypsin, amylase, lipase, target of rapamycin and insulin-like growth factor-I were up-regulated, and the highest values were observed with 1.58% dietary Thr or 1.58 and 2.08% dietary Thr, whereas the relative gene expression levels of eukaryotic translation initiation factor 4E-binding protein 2 gradually decreased (P<0.10) as dietary Thr levels increased up to 1.58% and thereafter significantly increased (P<0.05), which could explain that about 1.58% dietary Thr could improve the growth and development of digestive organs and activities of digestive enzymes of juvenile blunt snout bream.

Biography:

Jeongseon Kim is a Professor in the Department of Cancer Control and Policy, GCSP. Kim has been primarily involved in the investigation of dietary factors, using epidemiologic approaches, in the cause and prevention of chronic diseases especially cancer and its important conditions. Principal to this work in the field of nutritional epidemiology has been development of methods to measure dietary intake among populations. Thus she has dedicated continuously significant endeavor to the development and validation of dietary assessment tools to provide accurate and reliable assessments of a wide spectrum of nutritional factors. In addition, she has devoted to implement the evaluation of biological markers of dietary intake using particularly plasma and serum. Her ongoing research projects are 1) development of national cancer screening cohort 2) a study on dietary factors related to the prognosis of breast cancer patients 3) gene-diet interaction in the etiology of gastric cancer 4) evaluation of hazardous materials from food sources (e.g., methyl mercury, lead, and cadmium)

Abstract:

As chronic inflammation plays an important role in colorectal carcinogenesis, inflammation related gene-diet interactions may affect colorectal cancer risk. Therefore, we investigated whether genetic susceptibility alters the effect of diet-induced inflammation on the risk of colorectal cancer. This study included 701 colorectal cancer patients and 1,402 controls. We selected six polymorphisms in four genes (IL1B, TNF, PPARG and PPARGC1A) and calculated diet-induced inflammation using the dietary inflammatory index (DII). Multiple logistic regression models were applied to estimate odds ratios (ORs) and corresponding 95% confidence intervals (CIs) of the main effect of genetic variants and the DII as well as their interactions. Subgroup analyses were performed by anatomic site and other risk factors. Among the investigated polymorphisms, heterozygous carriers of rs3774921 in the PPARGC1A gene were at higher risk of colorectal cancer (OR=1.30; 95% CI, 1.05-1.62 for TC vs. TT). When the data were stratified by rs3774921 genetic variants, the role of a proinflammatory diet in colorectal carcinogenesis was more prominent among homozygous variant allele carriers (OR=4.35; 95% CI, 1.89-10.03 for high vs. low DII) (P for interaction=0.022). When stratified by anatomic site, this association was much stronger for rectal cancer patients (OR=7.57; 95% CI, 2.30-24.93 for high vs. low DII) (P for interaction=0.013). Additionally, this interaction was significant among those older than 55 years old, not exercising regularly and drinking alcoholic beverages. Conversely, the other investigated polymorphisms did not show any association or interaction with diet-induced inflammation in relation to colorectal cancer risk. This study suggests that a pro-inflammatory diet has a differential effect on colorectal cancer risk based on PPARGC1A genetic variation with differential associations according to anatomic location and other risk factors. Although the findings support the molecular link between metabolism and inflammation, future studies are required to confirm our results

Biography:

Neha Kapoor is a PhD candidate in Public Health Nutrition at University of Westminster, London, UK. She holds a MSc in Nutrition and a BSc in Human Nutrition and Dietetics. Her area of research is studying levels of malnutrition and developing nutritional strategies to control malnutrition among the Indian Palliative Cancer patients. She has worked as a Trainee Nutritionist at Glaxo SmithKline in the Department of Nutrition Claims R&D and has contributed to the development of new health food drinks targeted to improve nutritional status of the Indian population

Abstract:

Worldwide prevalence of malnutrition, amongst cancer palliative patients, is 81%. As cancer progresses, patients’ develop malnutrition owing to disease and chemoradiotherapy. Aim of this study was to improve nutritional status of female palliative cancer patients and their quality of life by counselling and providing nutrient rich natural food (IAtta). Female cancer patients (n=47) attending palliative care clinic (AIIMS, New Delhi); with symptoms of cachexia were randomly distributed into control group (CG, n=24) and intervention group (IG, n=23). IG received 100grams of IAtta and CG received wheat flour to be consumed as breads daily along with nutritional counselling for three months. Anthropometric measurements [weight, percentage body fat (%BF) and mid upper arm circumference (MUAC)] and quality of life (EORTC-C30 Questionnaire) were assessed at baseline and after three months. Data was analysed using paired t-test and Wilcoxon signed-rank test on variables assessed. P- value < 0.05 was considered statistically significant at 95% confidence interval. Of 47 patients, 17 in IG and 22 in CG completed the study. Patients in both groups maintained their body weights (IG, p= 0.284; CG, p=0.401) by end of the study. %BF (p=0.041) decreased significantly in the CG and were maintained in IG (p= 0.289). Furthermore, under quality of life domains, at end of study period; IG disclosed significant improvement in fatigue (p= 0.012) and appetite (p=0.004), while CG reported significant decrease in physical functioning (p=0.014). Nutrition sensitive intervention (IAtta) along with counselling may improve quality of life and stabilize body fat in female cancer cachexia patients receiving chemoradiotherapy

Biography:

Farshad Goodarzi Boroojeni has completed his second PhD at Institute of Animal Nutrition, FU Berlin and currently holds the position of Poultry Nutritionist and Researcher. He has 12 years of research experience in Animal Science and Nutrition. He has more than 13 publications in reputed peer reviewed journals. He is serving as a Reviewer for more than 10 reputed journals and as an Editorial Board Member of two international peer reviewed journals, “Journal of Veterinary Research and Animal Husbandry” and “Journal of Animal Nutrition”

Abstract:

Fermentation with probiotics and enzymatic pre-digestion may be able to improve the nutritional quality of pea. This study examined the impacts of different inclusion levels of raw, fermented or enzymatic pre-digested peas on nutrients digestibility in broilers. For fermentation, pea was mixed with water (1:1) containing 2.57×108 Bacillus subtilis (GalliPro®) spores/kg pea and then fermented for 48 hours at 30 oC. For the pre-digestion process, pea was soaked in water (1:1) containing 3 enzymes, AlphaGal™ (α-galactosidase), RONOZYME® ProAct (protease) and VP (pectinases) and incubated for 24 hours at 30 oC. Nine standard diets were formulated by supplying 10, 20 and 30% of the protein with raw, fermented and pre-digested peas. The apparent ileal digestibility of Ca, P, K, protein, AAs and fat were measured at d 35 . Data were subjected to ANOVA using the GLM procedure. Both types of processes reduced the raffinose, trypsin inhibitor and resistant starch. Increasing level of pea products reduced BWG and FI. Broilers fed pre-digested pea had the best FCR at d 35. Both processes had an identical effect on ileal digestibility of all nutrients except starch. The ileal digestibility of starch in raw pea was lower compared with both processed groups. The digestibility of Thr, Lys and Met were higher in 30% groups compared with 10% groups, while chicken fed 10% products showed highest digestibility of starch. In conclusion, both processes could relatively improve the nutritional quality of pea. Replacement of soybean by pea products at less than 20% inclusion level might have no negative impact on the nutrient digestibility and growth. These indicate the feasibility of both processes for nutritional quality improvement of pea, as a partial replacement for soybean in broiler feed

Biography:

Keonie Moore has completed her studies at the renowned School for Complementary and Natural Medicine, Southern Cross University, Australia. She has become a highly sought-after Presenter for her experience in scientific implementation. She is the Director of ReMed Natural Medicine Clinic, a multi-modality clinic that exemplifies scientific implementation in the Australian Health Sector. She is involved in clinical mentoring to enhance additional integrative clinics and practitioners in the assimilation of research findings and evidence into clinical practice. The highlights of her speaking engagements include presenting on Metabolic Syndrome to the Integrative Medicine Education and Research Group, Alfred Hospital and published ‘Metabolic Syndrome: A case for collaborative care’ in the reputable journal, Advances in Integrative Medicine and keynote speaker at the 2nd International Conference on Endocrinology, Chicago IL.

Abstract:

Whilst findings of epidemiological meta-analyses for an inverse relationship between dietary intake of vitamin E and risk of cancer have been inconsistent at best, vitamin E continues to attract interest due to its ability to protect cells from free radical damage and induce apoptotic cell death in various cell types. Earlier studies focused solely on the apoptotic action of alpha-tocopherol, with some authors even concluding that other vitamin E analogues have no influence on cell survival or the ability to induce apoptosis. However, we have seen an emergence of research into the cytotoxic and apoptotic activities of tocotrienols, particularly gamma and delta. Vitamin E exists naturally as a combination of all eight isomers. Further exploration of research reveals that supplementation with single isomers may impact the distribution of other vitamin E isomers and have the ability to cause detrimental outcomes such as reduced bone health and increased cardiovascular risk factors. For effective use of vitamin E in clinical cases, a deeper understanding of the vitamin E isomers and the dynamic balance between them is essential. Case studies in the management of glioma will be used as a guide to highlight the use of implementation science; to promote the integration of research findings and evidence into healthcare clinical practice. There will be a strong practice based focus on the role of vitamin E in enhancing cancer treatment outcomes, reducing toxicity of chemotherapy drugs to healthy cells and its role in attenuating oxidative stress in maintenance of health. Practical interventions to ensure safe administration of vitamin E and major flaws with current practices will be addressed.

Biography:

Yuta Maekawa is a fourth year PhD student at The United Graduate School of Veterinary Science in Yamaguchi University. His research focuses on the effect of lactoferrin, a glycoprotein found in various mammalian body fluids, on glucose metabolism. He was awarded the Student Award of XIIth International Conference on Lactoferrin, Structure, Function and Applications on 2015

Abstract:

Lactoferrin (Lf) is known for its physiologically pleiotropic properties. Nevertheless, the effects of Lf on glucose regulation have not been adequately analyzed. In the present study, we investigated whether Lf affects potential glycemic metabolism and glucose absorption from the small intestine in rats. Bovine Lf (bLf, 100 mg/kg) was intraperitoneally administered to rats before intravenous glucose injection (intravenous glucose tolerance test, IVGTT) or oral glucose administration (oral glucose tolerance test, OGTT). In IVGTT, bLf pretreatment had no significant effect on plasma glucose or insulin. In OGTT, the bLf group tended to show lower plasma glucose at and after the 15-min peak than the control group, and decreased at 180 min. The change in plasma insulin from 0 to 30 min was higher in the bLf group than in the control group. Total plasma GIP was lowered at 60 min by the bLf treatment, while an immediate increase in total plasma GLP-1 was observed within the bLf group undergoing OGTT. In addition, bLf was associated with an increase in the amount of glucose absorbed into the everted jejunum sac. These results suggest that Lf may have a potential to suppress hyperglycemia, accompanied by plasma insulin elevation via transiently accelerating GLP-1 secretion, and that Lf even enhances glucose absorption from the small intestine. Lf may have the potential to promote glucose metabolism via the so-called incretin effect

Biography:

Faheem Shehzad BALOCH has completed his PhD at the age of 31 years from Çukurova University under cultural Exchange Scholarship program. He worked as assistant professor at NiÄŸde University during 2013-2014. Now he is working as assistant professor at Abant izzet baysal University. He is orking on genomics tools in cereals and legumes for the trait of interest. He has more tha 35 publication in journal of international repute. He has been serving as an editorial board member of some national and international journals

Abstract:

Mineral malnutrition particularly Zn and Fe deficiency are major source of concern for public health resulting in many kinds of mental and physical disorders in developing and least developed countries. Phaseolus vulgaris L. is among one of the most important legumes grown worldwide that has appeal to farmers and consumers and represent about 50% of grain legumes used for human consumption in many parts of the world. Therefore, biofortification of the common bean is one of the major option for eliminating the mineral malnutrition in the developing world. There are various strategies for biofortifying the common bean seed through conventional plant breeding and as well integrating using modern biotechnological techniques. Therefore, to achieve the objectives for transcriptomics, the NRAMP (the natural resistance-associated macrophage protein) genes considered to be potential candidates for improvement of mineral nutrients like zinc and iron. Transcript expression of PvNRAMP3 was observed and expressed at different stages of pod development. The expression was increased with increase in pod length of common bean. PvNRAMP4, PvNRAMP5.2 and PvNRAMP1, PvNRAMP7and PvNRAMP5.1showed negligible or undetectable expression in the pods. In short, PvNRAPM3 seems to be excellent candidate however, detailed functions such as tissue specificity and subcellular localization of the gene will be explored in future. Besides this, We have a TÜBÄ°TAK (National) Project for increasing mineral contents in common bean seeds and identify linked DNA markers through genome wide association mapping (GWAS) using DArTseq and SNP markers. We are using 192 common bean genetic resources (landraces), collected from various topographical positions of Turkey, for phenotyping for Zn and Fe contents of seeds under multi locational field trials at various environmental locations. Same set of germplasm is being genotyped by genotyping by sequencing (GBS) technology and hundreds of thousands markers will be used for association mapping studies. Bioinformatic applications will be utilized to identify linked markers though linkage disequilibrium technique and identified linked markers will be further used for marker assisted selection in current breeding programs

Biography:

Alexandra M Johnstone is recognized as a leading innovative UK Researcher within the field of human appetite control and specifically, the role of dietary protein with strong emphasis of application in the food industry. Since completing her PhD in 2002, she has produced an extensive publication record (>60 peer reviewed publications in high impact journals). Her philosophy is ‘Better food for better health’. She is a partner in three EU grants (SATIN, Full4Health, NeuroFAST), a Reviewer of many international journals and works with a variety of stakeholders for research impact (Non-Government Organizations, Policy, Media & Food Sector)

Abstract:

With the ever-increasing obesity problem comes the search for effective dietary strategies to either prevent weight gain, promote weight loss or to maintain a lower body weight. Although one diet does not fit all, high-protein diets seem to provide a tool to promote appetite control and hence body weight control. Dietary strategies that can help reduce hunger and promote fullness are beneficial, since these are limiting factors for success. High protein diets, specifically those that maintain the absolute number of grams ingested, whilst reducing calories are a popular strategy for weight loss (WL) due to the effects of protein induced satiety to control hunger. This effect has been shown in ad libitum clinical studies lasting from 1 to 14 days, up to 6 months. In addition, greater WL has been achieved in comparison to control diets. The mechanisms responsible for the high satiating effect of protein are not known but likely to be around amino acid metabolism and food-gut-brain interactions linked to gut hormones. It is still not clear exactly the amount (g or %), type of protein (vegetable, diary, animal) that is required to promote satiety thus these mechanisms will be a focus for future research. Both the safety and efficacy of high-protein WL diets have been questioned, particularly in combination with low-carbohydrate advice. This has been recently reviewed with growing evidence to support the use of high-protein, moderate-carbohydrate diets as a dietary tool to achieve weight control (30% protein, 30% fat and 40% carbohydrate).

Biography:

Abstract:

In these days the most important subject that the people are thinking about is about on “healthy eating” such as which food is good for eating and which should be prohibited. Despite professionals and laymen advices to us what to eat to be healthy, recently scientists have some good suggestions about “healthy diets” that are depends on molecular biology, genetics, toxicology, and chemistry revealed some complex interrelationships of food with toxicology nutrition with detoxification and diet with the prevention of degenerative disease that should finally enable us to make judgments concerning us about “Healthy diets” In order to have healthy life, healthy food or diet is very important for this reason it should be always take in consideration The importance of diet and nutrition in the detoxication of chemicals Under these subject various facts must be taken in consideration such modification of intestine absorption and intestine cell. Under the the heading of diet it covers very large area from drug to processed food or processed food to raw vegetables or even vitamins. Also the term of Cell includes cell of food or living organism. On the other hand, signaling between cell are very important even for the toxic consequences of diet and wealth such as it was shown that there is cancer cell signaling targeted, by spice Derived nutraceuticals or other type cellular signaling systems intracellular mechanisms that are controlled by intracellular calcium. The consequences of having food are Either good healthy life or life with lot difficulties such as disease the worst is cancer, but having healthy food can also prevent the toxic affect of food

Biography:

Abstract:

Oxidative stress is the result of an imbalance between excessive reactive oxygen species and anti-oxidants mechanisms. Recently, the anti-oxidant caffeic acid phenethyl ester (CAPE) and Epigallocatechin Gallate (EGCG) have come to the attention of researchers. CAPE is an active component isolated from the propolis found in honeybee hives. CAPE has been determined to have neuroprotective, anti-oxidant, anti-inflammatory and anti-apoptotic properties. It is nontoxic and is consumed as a traditional medicine. As a potent anti-oxidant and NF-ĸB inhibitor, CAPE is more effective than the other types of natural flavonoids found in fruits, vegetables and tea. In vivo studies showed that CAPE prevents the formation of ROS, malondialdehyde (MDA) and peroxynitrite. (EGCG) is also an anti-oxidant polyphenol found in green tea. It may have health benefits as a nutritional supplement for cancer, atherosclerosis, diabetes, neurodegenerative diseases and HPV virus infection. Anti-oxidant effects of EGCG protect cells from lipid peroxidation and DNA damage induced by reactive free radicals. EGCG directly interacts with proteins and phospholipids in the plasma membrane and regulates signal transduction pathways, transcription factors, DNA methylation, mitochondrial function and autophagy to show many of its beneficial biological actions. EGCG induces apoptosis in several human cancer cell lines including breast, prostate, lungs, ovaries, and liver. In this presentation, the beneficial effects of CAPE and EGCG on MCF-7 and MDA 231 breast cancer cell lines will be disscussed

Biography:

Tülay Merve Temel is postgraduate student at Bioengineering Department of Yıldız Technical University, Ä°stanbul, Turkey. Her working areas are biomaterials, lipid technology, environment technology and silica aerogels production and characterization.

Abstract:

A wide range of nutritional supplements have been suggested to prevent the inadequate daily intake of minerals (calcium, iron, magnesium, silica), vitamins and other nutrients that are essential for human health. Silicon is one of the most abundant trace minerals in the human body which is especially found in connective tissues as the aorta, bone, skin, and tracheas [1,2]. Further, it may be found in heart, liver, lung, and muscle in the form of ortho-silicic acid at lower levels. In this regard, silicon is an essential mineral for bone mineralization, collagen synthesis, skin, hair and nails. Its supplementation increases bone mineral density and thus reduces bone fragility. Silicon has additional important health effects in relation to immune system enhancement. Furthermore, silicon contributes to the formation of cross-links between collagen and proteoglycans [3]. Since silica has a fundamental importance to human health, there is considerable attention by the medical community to improve silica based dietary supplements. The main aim of this study is to review the researches that address the nutritional importance, biological and therapeutic effects of silica.

Biography:

Selda Demirtas, graduated from Hacettepe University, Faculty of Medicine, Ankara-Turkey in 1990. She has a Specialist Degree on Clinical Biochemistry, 4 years of post graduate after MD from Ankara University, Department of Biochemistry, in 1995.She is currently Head of Department of Biochemistry in Ufuk University, School of Medicine in Ankara-Turkey. Her researches focus mainly on vitamin B12. She was the first to report of relationship between cognitive failure and Vitamin B12 deficiency in young and middle age individuals and Reference Ranges of Vitamin B12, Holotranscobalamin and Methyl malonic acid in Turkey. She has more than 60 published researches

Abstract:

Background: The growing data indicates that subclinical cobalamin deficiency (SCCD) is being diagnosed more than ever. Because of its common occurence than classical cobalamin deficiency, SCCD is an important condition for public health. One question with SCCD is whether it is only a state of mild metabolic abnormality without any clinical signs or symptoms or is associated with clinical signs and symptoms, albeit vague. The exact prevalence of SCCD which is more frequent in young and middle-aged adults is largely unknown . Furthermore, the absence of ideal test marker for cobalamin deficiency is aggrevate the situation. It is clear that these problems can be solved with the evaluation of reference values of cobalamin and related tests in each population. In our current reference range study, serum cobalamin, folate and holotranscobalamin (Holo-TC) values, plasma homocystein and methyl malonic acid (MMA) levels were assayed in over the 400 healthy volunteers. The results indicated that, all of the tests except for the plasma homocysteine and MMA were found lower than detected by the manufacturer. They were divided to subgroups with respect to ages. Cobalamin and Holo-TC values of youngest group were differ from the oldest group. So, we suggest the use of own reference values for each population and Holo-TC should be used together with the serum cobalamin in diagnosing SCCD. In the another study, we observed that the cognitive test scores elevated with the increase of Vitamin B12 in young and middle-aged. In conclusion, SCCD is a hidden health problem that could be manifested by itself with a cognitive failure in the young and middle-aged population. The serum cobalamin around 190-250 pg / ml should be considered for the diagnosis of SCCD which manifested by the cognitive impairment and cognitive functions should be assayed to provide exact diagnose.

Biography:

Yen Ting Tung studying in Taipei Medical University of Nutrition and Health Sciences. He study in the effect of phytochemicals on leiomyoma and cancer disease.

Abstract:

Women suffering from leiomyoma account for a quarter of the world's female population. Study indicate that leiomyoma may be expand by estrogen imbalance, abnormal deposition of extracellular matrix and stem cell proliferation. Melatonin is an endogenous hormone produced by the pineal gland in the brain, can regulate physiological clock and secrete estrogen. In past studies, melatonin have antioxidant, anti-inflammatory, inhibit cancer cell growth and metastasis. In this study, we investigated the antitumor effect of melatonin on leiomyoma and smooth muscle cell (ELT3, UtSMC) in vitro. We examined the effects of melatonin on leiomyoma stem-like cells number, cell proliferation, cell cycle regulation, apoptosis or autophagy related protein expression and accumulation of extracellular matrix. 1. Melatonin significantly inhibited the proliferation of leiomyoma cell in a dose-dependent and time-dependent manner. 2. Melatonin reduced on leiomyoma stem-like cells number and induced leiomyoma cell early and lately apoptosis. 3. Melatonin induced apoptosis and autophagy related protein expression. 4. Melatonin inhibited accumulation of extracellular matrix on leiomyoma cell. These findings suggest that melatonin may inhibits leiomyoma cell proliferation and have the potential to improve the development of leiomyoma associated with functional food

Biography:

Li-Chun is a graduate student from Taipei Medical University of Nutrition and Health Sciences. She studies in the effects of chinese herbs and phytochemicals on cancer disease

Abstract:

Doxorubicin (Dox) is widely used for the treatment of several cancers. However, multi-drug resistance (MDR) is a major clinical problem and an important cause of treatment failure. How to increase chemosensitivity and reduce the dose of chemotherapeutic agents, in order to prevent drug side effects and the development of new chemotherapeutic agents are important. Uterine sarcoma is a rare gynecologic cancer. The patients sometimes are asymptomatic. It has the high degree of malignancy, poor prognosis and high mortality rate. It often be misdiagnosed as uterine fibroids. Isoliquiritigenin (ISL) is the flavonoid with chalcone structure isolated from licorice root. ISL has been shown to possess significant anticancer activities in many cancer types. In this study, we investigated the antitumor effects of ISL on human uterine sarcoma cancer cell MES-SA and the multi-drug resistant human uterine sarcoma cancer cell MES-SA/Dx5 and MES-SA/DxR-1. Our present results showed that, treatment of ISL alone or combination with Dox significantly inhibited the growth of cancer cells and increased the proportion of subG1 phase. Flow cytometry analysis indicated that ISL induced apoptosis and necrosis. In addition, ISL enhanced the autophagy associated protein expression of LC3Bâ…¡ and apoptosis associated protein expression of cleaved-PARP. ISL also inhibited Bcl-2 and phospho-mTOR protein expression. Moreover, ISL inhibited the migration of the cancer cells. Taken together, ISL can inhibit human uterine sarcoma cancer cells through apoptosis as well as autophagy, and increase the chemosensitivity to doxorubicin in multi-drug resistant human uterine sarcoma cancer cells MES-SA/Dx5 and MES-SA/DxR-1

Biography:

Hsin-Yuan, Chen has completed her Master Degree at the age of 25 years from Taipei Medical University. She had an honor to win the First Prize in Nutrition & Biotechnology Group in TMU 2015 Teachers and Students Joint Academic Symposiumas an “Excellent Research Paper”

Abstract:

Endometrial cancer occurs in women after menopause, is the fourth most common cancer in women in the United States. In Taiwan, due to the widespread use of hormone replacement therapy, the incidence of gynecologic cancer climbs to first place. In recent years, western countries begin the widespread use of herbal therapies, Isoliquiritigenin (ISL), one of the active components in licorice plant flavonoids, in past study, ISL had antioxidant, anti-inflammatory and tumor suppression effect. In this study, we investigated the antitumor effect of ISL on human endometrial cancer in vitro and in vivo. We used human normal endometrial cell lines, T HESCs, and human endometrial cancer cell lines, Ishikawa, HEC-1A and RL95-2 as targets. To examined that the effect of ISL on the cell proliferation, cell cycle regulation, and apoptosis or autophagy related protein expression. In addition, we conducted in vivo experiment to confirm the inhibitory effects of ISL on cancer cell. As the current results show, ISL significantly inhibited the viability of cancer cell in a dose-dependent and time-dependent manner, but has little toxicity on normal cell. And also, flow cytometry analysis indicated that ISL induced sub G1 phase arrest. Mechanistically, ISL enhanced the expression of PARP/LC3B â…¡ protein associated with apoptosis/autophagy. Furthermore, ISL suppressed the xenograft tumor growth in vivo. These findings suggest that ISL is a candidate agent for the treatment of human endometrial cancer, and may play an important role in ISL-induced apoptosis, autophagy and cell growth inhibition

Biography:

Nathalie Estephan has completed her PhD in 2005 from AgroParisTech, France. She is an associate professor at the department of Chemistry and Biochemistry and the Associate Dean of the Faculty of Sciences at USEK. Her field of research is analytical chemistry and chemometrics applied to agrofood, health and environment

Abstract:

Recently, the use of food silicone molds especially in baking cakes, bread and food in general has grown considerably. Their increasing use is due to the fact that these molds are malleable, non-adhesive, easy to clean, unbreakable, withstand heat up to 280oC or more in some cases. These molds are formed of polymerized siloxane. This is a mixed inorganic-organic polymer, whose skeleton is a silicon alternating and oxygen with organic side groups attached to silicon atoms. Two organic functional groups, usually methyl or phenyl groups, are attached to each silicon atom. Frequent use of these molds either for domestic or industrial scale requires a thorough analysis of the behavior of the mold-food system in real conditions of use of this material. The aim of this work is to study the contact food-silicone mold as well as the effect of this contact on both the food and the mold. Our first tests were conducted using the Fourier Transform mid-infrared spectroscopy (FTIR). Preliminary results are promising, the FTIR allowed us to detect differences in behavior between silicone molds based on heating and other parameters. Spectral data were analysed using Principal Components Analysis (PCA) which allows us to extract useful information. The originality of this work lies in the combination of silicone molds footprints by infrared with chemometrics.

Biography:

Joseph Saab completed his phd degree in 2004 and obtained his HDR degree in 2014 at Claude Bernard University –Lyon1- France. He is the head of Chemistry and Biochemistry department at the Holy Spirit University of Kaslik-Lebanon. He published more than 16 papers in reputed journals and serving as member of experts’ committee in AMM in the ministry of Health - Lebanon

Abstract:

Food contamination can result from various interaction between food and packaging materials. The migration process is determined by the properties of the migrant, the polymer and food simulant (solid/liquid , hydrophilic/lipophilic) and by temperature. Practically, volatile and non-volatile compounds can migrate through the different layers (primary or secondary packaging materials) to the food due to diffusion and partition phenomenons. Both phenomenons are related to the physical properties of the migrant, its high solubility in a hydrophilic food simulant for example suggest a high rate of transfer from pacaging material to food. In this work, we studied the Di-isobutyl phthalate, a known food packaging contaminant. we present the experimental measurement of the octanol-water partition coefficient known as best descriptor of a compound behavior between hydrophilic and lipophilic phases, in addition of its vapor pressure measurement in function with temperature (313.15 K to 423.15K). The measured partition coefficient is 4.34 (%RSD= 1.9, n=3), performed by“shake-flask” method, it reflects a significant lipophilicity suggesting a higher migration rate to lipophilic food matrices. Vapor pressure measurements were performed using the transpiration method also called dynamic saturation method. Results showed an increasing vapor pressure with temperature ranging from 0.041 Pa at 313.15K to 215.62Pa at 423.15K (%RSD<1.8, n=5 for each temperature). The increasing vapor pressures of Di-isobutylphthalate in function wih temperature proves the effect of the temperature on the migration rate demonstrated in the majority of the migration studies. Finally, the study of the migrant properties will extent the knowledge of its migration into food