Day 1 :
- Clinical Nutrition | Nutritional Science | Clinical Nutrition
Location: Webinar
Session Introduction
Jyoti D. Vora
CEO, Dhirang Consultants, India
Title: An Insight InTo Wheatgrass (Triticum aestivum): Application Of The Modular Approch Of Haccp Or Total Quality Management (TQM)
Biography:
Dr. Jyoti D. Vora, an eminent Biochemist is the Head ofthe Department of Biochemistry and Food Science and Quality Control, Ramnarain Ruia College, India. Dr. Jyoti D. Vora has graduated with Honors in Microbiology and Chemistry from University of Mumbai in 1977, followed by Post graduation in Biochemistry by research in 1980.In 1984, she completed her Doctoral degree inBiochemistry from IIT, Mumbai. She has been conferred various academic honors including the Fellowship of the Society of Science, MASFFBC at Harvard Medical School, Boston, USA.She is an avid researcher in the field of Biochemistry, with over 40 publications in various peer-reviewed national and international scientific journals. She has also deliveredlectures and oral presentations as an invited speaker at several national and international seminars, conferences. She has authored of 3 books in the realm of Biochemical research published by Lambert Academic Publications, Germany.
Abstract:
Hazard Analysis Critical Control Point (HACCP) is an emerging concept protecting any and every manufacturing process, right from gathering the requirements up to the final step of development of the product. This can be applied to any desired and relevant field for the optimization of the over-all process and attaining the best possible outcomes form the optimized process. Total Quality Management (TQM) forms the basis of HACCP Analysis and this process is employed during the novel product development. The idea of development of a novel recipe with the use of wheatgrass (Triticum aestivum) was to present this valuable plant in an alluring form, which can be enjoyed by all. The wheatgrass plant and its preparations have been consumed since ages, in different forms in order to maintain optimum health conditions. Determining various critical control points for the entire recipe development process and suggesting remedial measures was the chief aim. The entire procedure of the novel product development can thus be validated with the help of HACCP and is a step towards corrective action required for enhanced product quality, enriching the total product likeliness and acceptability. The novel product can be further used as a nutraceutical, promoting optimum health and nutrition.
Biography:
Gaia Rocchitta has completed her graduation in chemistry in 1999 with a thesis about polyphenols in red wines, then she completed her PhD in Neuroscience at School of Medicine of Sassari University (Italy) in 2004. She was a Postdoctoral fellow at School of Chemistry and Chemical Biology, University College, Dublin (Ireland) in 2006, working on the development of amperometric biosensors for in vivo monitoring of neuro chemical compounds. She currently is a tenured researcher and lecturer in Pharmacology and Nutraceutical at School of Medicine of Sassari University (Italy). Dr Rocchitta has been a tutor for numerous PhD projects mainly focused on the development of analytical devices for the monitoring of neuro chemicals in vivo, but also of nutraceuticals in agrifood matrices. Moreover, she has published about 60 papers in peer-reviewed journals of international relevance.
Abstract:
The brain is influenced by substances present in the diet (as essential fatty acids, including omega- 3 polyunsaturated fatty acids, but also essential amino-acids, vitamins and minerals).It has been postulated that food can have an impact on brain structure and functioning. Actually, most micronutrients (trace-elements or vitamins) have been directly linked to the setting of cerebral functions. For example, some micro-elements, as vitamin B1, that controls cognitive performances, especially in the elderly, it has been demonstrated being implicated the use of glucose by nervous tissue. So as vitamins B6 and B12, among others, are involved in the synthesis of some neurotransmitters. It has been also demonstrated that nerve endings contain the highest concentrations of vitamin C in the human body, demonstrating the fundamental importance of this essential vitamin. It has been proposed that vitamin D could be of interest in preventing neurodegenerative or neuroimmune diseases and vitamin E (tocopherols and tocotrienols), in particular alpha-tocopherol is actively up taken by brain and directly implicated in nervous membranes protection. Vitamin K has also been shown to be implicated in brain biochemistry .Even trace-elements play an important role in brain. In fact, magnesium has been demonstrated to have an important role in ionic and oxidation-reduction regulation More, an impaired copper metabolism homeostasis has been linked to Alzheimer disease, while iodine has been linked to energy metabolism of the cerebral cells. Moreover, it has been largely proved that manganese, copper, and zinc play a pivotal role in enzymatic protection mechanisms against reactive oxygen species. So, food nutrient composition can have either immediate or long-term effects, positive or negative. It has been postulated that brain diseases during aging can also be due to dietary deficiencies in anti-oxidants and nutrients (non-essential micronutrients such as polyphenols or trace elements and vitamins) and therefore lead to failure for protective mechanism, for example related with protection against free radicals.
Laetitia Aerts
Catholic University of Leuven, Belgium
Title: Therapeutic targeting of PC1/3 deficiency: from obesity to gastrointestinal disorders
Biography:
Laetitia Aerts is a biochemist and biotechnologist and ending PhD at the laboratory for biochemical neuroendocrinology at the centre for human genetics at KU Leuven. She won several scientific awards as poster and presentation awards (ref Science battle, Diabetes Liga). Beside her role as an assistant teacher and supervisor of master students, she started a new thematic program metabolic diseases in the doctoral school of biomedical sciences at KU Leuven. She obtained numerous certificates of statics, laboratory animal science, the floor is yours training, strategic management in pharmacological sector.
Abstract:
Proprotein convertase 1/3 (PC1/3), encoded by the PCSK1 gene, is an enzyme that belongs to the family of seven highly conserved subtilisin-like serine proteases. PC1/3 is expressed in neuronal and endocrine cells, including endocrine cells in the gut, the β cells in the pancreas and in hypothalamic nuclei (POMC and AgRP neurons) known to function as centres for energy homeostasis. Loss-of-function mutations in PCSK1 cause an autosomal recessive disorder characterized by childhood obesity, malabsorptive diarrhea and other endocrinopathies. The gastrointestinal complications start immediately after birth and causes chronic diarrhea, weight loss, dehydration and metabolic acidosis which can lead to death in early childhood. After hospitalization and parental nutrition these PCSK1 null patients are reported with severe early onset obesity and postprandial hypoglycaemia. PC1/3 is highly expressed in the enteroendocrine cells of the small intestine and co-localizes with gut hormones like cholecystokinin (CCK), glucosedependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1,2 (GLP-1 and GLP-2). Remarkably however, the gastrointestinal tract has a (near-)normal histology and no chronic infection. How PC1/3 deficiency leads to chronic diarrhea is still unclear. Because of the appearance of the idiopathic chronic diarrhea in the PCSK1 null patients, has caused a shift in the clinical paradigm of PC1/3 deficiency and highlighted the current lack of understanding the role of PC1/3 in the gastrointestinal tract. Given the role of enteroendocrine factors secreted by gastrointestinal cells in energy and blood glucose homeostasis, a better understanding of this phenotypical aspect is dearly needed. Therefore we characterize the novel Pcsk1-/- mouse model, which is a representative mouse model to study the metabolic disorder of PC1/3 deficiency because of the duel phenotype: the obesity and gastrointestinal phenotype.
Kimberly Janiszewski
Spalding University School of Professional Psychology, USA
Title: The Prevalence of ACEs Among Obese Pediatric Patients Presenting in Primary Care
Biography:
Kimberly Janiszewski is a fourth year doctoral student in Spalding University School of Professional Psychology’s clinical psychology program. As part of her training, she is completing a rotation in an integrated primary care setting where she provides brief therapy and intervention to an underserved population on the outskirts of Louisville, Kentucky. Kimberly strongly believes that mental health is just as important as physical health and that each one has significant impact on the other. Kimberly’s research interests include trauma, obesity, and resilience when facing chronic health conditions especially within pediatric populations.
Abstract:
The obesity epidemic has been of increasing concern in the United States for years (Ogden et al., 2014). According to the CDC, childhood obesity affects nearly one fifth of the children in the U.S. (Hales et al., 2017). Many of the widely known risk factors have been identified, however, there are other factors that are harder to identify (Agras et al., 2004). Research has established a relationship between stress and weight gain. Persistent and prolonged stressors can lead to an overreactive response to stress and the dysregulation of hunger hormones as well as maladaptive coping mechanisms such as overeating (Bose, Oliván, & Laferrère, 2009; Dallman et al., 2003; Sapolsky, 2004). An example of the types of stressors frequently associated with weight gain is traumatic experiences or adverse childhood experiences (ACEs). In addition to a heightened stress response, the emotional dysregulation resulting from trauma is frequently associated with disordered eating behaviors (Dye, 2018; Micanti et al., 2015). While adverse childhood experiences (ACEs) have been identified as risk factors for multiple health issues including obesity in adults, there is a lack of research identifying if this risk factor increases risk of obesity earlier in life as well (Felitti et al., 1998). To fully understand the childhood obesity epidemic and effectively implement preventative and remedial treatments, we must understand the impact traumatic experiences have on the health of children prior to adulthood, when the treatment of obesity related illnesses becomes significantly more complex with varying comorbidities and other obstacles. By collecting archival data from electronic health records at community health clinics, this study plans to investigate relationships between pediatric patients with a history of ACEs and their BMI. Based on similar studies with adults, we expect children who have ACEs to have higher BMIs, and the severity increasing as number of ACEs increases. The results of this study have important implications for the treatment of pediatric obesity in primary care. Not only does it highlight the importance of educating patients on preventing the occurrence of ACEs, but it provides justification for early intervention provided by mental health providers in integrated healthcare settings. The processing of trauma with children and families and provision of education on healthy coping offers a new avenue for the treatment of pediatric obesity in primary care with the ultimate goal being prevention of childhood obesity, generating a more positive trajectory for health and wellness into adulthood.
Marcello Menapace
M&Ms Consulting Ltd, Borehamwood, UK
Title: The Birth of a New Medicine - Western Constitutional Nutrition
Biography:
Marcello Menapace has completed his Master’s degree at the University of Milan (IT) in Chemistry, his second Master’s degree in Business Administration (MBA) at the London School of Business and Finance in London (UK) and his PhD in Life Science at the H. S. University in Philadelphia (US). He is the director of M&Ms Consulting Ltd, a high-end consultancy service organization. He is a researcher, philosopher, scientist, medical writer, and professional regulatory consultant (MTOPRA) and has published more than 15 papers in reputed journals and been serving as editorial board member in several of International Journals.
Abstract:
All of the main historical types of alternative forms of medicines which fall into the category of traditional complementary and alternative medicines (TCAM) have in common the idea that food has peculiar properties. Both traditional Chinese medicine (TCM), Unani Tibb, traditional Japanese medicine (TJM), Ayurveda, and all other traditional medicines teach that foods can be divided in two ways according to their qualities. These qualities are hot/cold and dry/moist and based on these all TCAM suggest to use these foods to harmonize any disequilibrium (disease) that a person may have (dietetic treatment) due to its individual temperament (constitution), at any specific point in time. All TCAMs have developed from a common ancestor medicine and have splitted into several branches each focusing on their own peculiar treatment patterns. While Unani has taken the concept of the four humours from ancient Greek medicine, TCM and Ayurveda utilized 5 and 3 elements, respectively, as a foundation and have established their own treatment system around this. Similarly, modern blood type diet (BTD) approach considers humans divided by blood types and assigns to each a peculiar set of foods adapt to their biochemistry through a process of experimentation. Both dietary practices are not mutually exclusive, but can be suitably and positively combined into a new system of medicine where diet and practice is at the centre. This new system will take advantange of the millennial tradition of ancient medicine and the novel advances of biochemistry to provide a truly individualized medicine.
Marcello Menapace
M&Ms Consulting Ltd, Borehamwood, UK
Title: Nutrition and the Holobiont - New Insights into an Old Problem
Biography:
Marcello Menapace has completed his Master’s degree at the University of Milan (IT) in Chemistry, his second Master’s degree in Business Administration (MBA) at the London School of Business and Finance in London (UK) and his PhD in Life Science at the H. S. University in Philadelphia (US). He is the director of M&Ms Consulting Ltd, a high-end consultancy service organization. He is a researcher, philosopher, scientist, medical writer, and professional regulatory consultant (MTOPRA) and has published more than 15 papers in reputed journals and been serving as editorial board member in several of International Journals.
Abstract:
The earthshattering concept of the holobiont has sent ripples into the well-established disciplines of ecology and biology and is now promising to change forever the landscape of medicine too. The once appraised thought of sterility of the organs and internal tissues is now laid hopelessly in waste and in its stead stands the revishing idea of a molteplicity of species fighting for dominion in whatsoever niche within our body. The thousands of articles and experiments completed over the last twenty years are a testimony to the dreadful idea of contamination of our organism which is deemed a house full of uncountable species of bacteria, protozoa, fungi and viruses. These microorganisms compete for the limited food that we provide and follow a pattern dictated by our biochemistry: the blood typology of our body. These minute chemical compounds that star each cell (proteins and lipids, alike) have the power to recognize and be identified by the microflora circulating and surrounding the cells and tissues and thence secretly decide which types of germs prosper and which wane. Since these microscopic beings have a vast array of biochemical engines (enzymes), the different species would force the holobiont to display distinct biological features depending on the blood group of the individual. Finally, the picture of the holobiont is complete only once we consider the proper diet for these different biotypes as a food for the diverse microorganisms rather than for the human beings: the right food materials will allow the right microflora to thrive.
Kathleen C. Voigt
Rush University School of Nursing, USA
Title: Community Supported Promotora-Led Nutrition Program to Prevent Childhood Obesity Targeted to High Risk Latino Families
Biography:
Kathleen Voigt is an adult and family nure practitioner with over 30 years experience in health care. She was the Executive Director for Clinic Research Trials at the University of California San Diego and provided health care leadership for the Department of Defense and State Department over 5 years in the middle east. She is completing her doctorate in Transformative Leadership in Population Health from Rush University School of Nursing, Chicago, IL
Abstract:
Child abuse and neglect for adverse child experiences is a global concern. Negative child health risks in this population are many and include childhood obesity related to malnutrition. Decreasing the risk for childhood obesity in Latino children can be successful using culturally tailored nutrition programs targeting parents of preschoolers. This project implements a nationally validated nutrition program using a quasi-experimental, before and after design, conducted in Summer 2020. The target population is Latino families with history of child abuse and neglect participating in behavioral health services in the US southwest. The program goal is to increase the knowledge base in nutrition and healthy food selection in the target population. A partnership between a nonprofit community behavioral health services organization and a university-affiliated, federally funded nutrition program was presented to Latino families at risk for poverty and food scarcity. Participants volunteered through intra-agency recruitment attending an 8-week course of one-hour modules using the ZOOM on-line platform for instruction. Simulation learning experiences, guided by the Social Cognitive Theory, encouraged self-efficacy for behavioral changes in healthy food selection. Intervention evaulation, guided by the Logic Model, includes program outcomes, impact, and stakeholder resources and inputs. Data analysis is a comparison of participant’s pre-test and post-test knowledge and behaviors of healthy food selection with national EFNEP data. This collaborative effort provides an opportunity to reverse adult health risks related to childhood obesity based on national, state, and local community alliances sharing scare resources to make a collective impact.