Yuxiao Zou
Guangdong Academy of Agricultural Sciences, China
Title: Silkworm pupae oil exerts hypolipidemic and antioxidant effects in a rat model of high-fat diet-induced hyperlipidemia
Biography
Biography: Yuxiao Zou
Abstract
Silkworm pupae are good resources of edible oil that is especially rich in unsaturated fatty acids and considered an excellent dietary supplement for hyperlipidemia. In order to investigate the effects of silkworm pupae oil (SPO) on the lipid profile and oxidative stress, dyslipidemic-diabetic Wistar rats (n = 50) were divided into five diet groups of 10: normal control (C); high-fat diet control group (HF); and three other groups fed a high-fat diet with SPO supplementation (1, 2, or 4 mL•kg-1•d-1) orally. Groups fed with SPO had significantly lower concentrations of serum total cholesterol (TC) (P<0.05) and low-density lipoprotein cholesterol (LDL-C) (P<0.05) compared with the HF group. In regard to antioxidant parameters, except for levels of glutathione peroxidase (GSH-Px) in the liver, 2 and 4 mL•kg-1•d-1 of SPO supplementation leaded to higher total antioxidant capacity (T-AOC) (P<0.05), superoxide dismutase (SOD) (P<0.05) and GSH-Px levels (P<0.05) and lower malondialdehyde (MDA) levels (P<0.05) both in serum and liver versus the HF group. The study indicated that supplementation with SPO can improve lipid profiles and alleviate oxidative stress in dyslipidemic-diabetic rats induced by high-fat-diet, which showed great potential in ameliorating disorders of glucose and lipid metabolism.