Nutrition

Biography

Biography: Nihal El Habachi

Abstract

As oophorectomised groxidative stress is proposed to be responsible for many of the menopause associated disorders, antioxidants may play an important role in this situation. In this study, forty albino female rats were divided into 4 groups: normal control group, oophorectomised group, oophorectomised group treated with 17- estradiol and oup treated with antioxidants(Vitamin C and low dose Vitamin A).The following were measured: total antioxidant (TAO) and malondialdehyde (MDA), lipid profile, serum insulin, glucose and homeostasis model assessment-insulin resistance (HOMA-IR), bone specific alkaline phosphatase (BALP), urinary hydroxyproline, weight gain and visceral fat. A positive correlation was found between MDA and low density lipoprotein-cholesterol (LDL), HOMA-IR and BALP and urinary hydroxyproline level . Those results denoted that oxidative stress might be a cause of dyslipidemia, insulin resistance and osteoporosis associated with menopause. Both E2 and vitamins in oophorectomised rats led to a significant decrease in MDA , weight gain, visceral fat , cholesterol , LDL cholesterol , and significant increase in HDL and TAO levels compared to oophorectomised rats. Also, both treatments led to a significant decrease of HOMA-IR, BALP and urinary hydroxylproline .An interesting finding was detected where oophorectomised rats showed a decrease in triglyceride level which was significantly increased by E2 administration whereas antioxidant administration produced no change . Our results denote the beneficial effects of antioxidant administration in surgically induced menopause in rats regarding oxidative stress, weight gain, atherogenic lipid profile , insulin sensitivity and bone turnover similar to that of E2.