Nutrition

Biography

Biography: Talha Muezzinoglu

Abstract

In this study, the concentrations of different trace metals, including Fe, Mg, Cd, Ni, Zn, Cu, Se, Ca and Boron (B) in malign and benign prostate tissues, were determined by Induced Coupled Plasma-Mass Spectroscopy and Induced Coupled Plasma-Optic Emission Spectroscopy. We also analyzed the relationship of these concentrations with histopathology stage, PSA and clinical survey. It was investigated the possible role of tissue trace element levels in development of prostate cancer and the relationship between histopathologic stage, preoperative PSA levels and biochemical PSA recurrences. Cd, Ni and Ca average concentrations were determined lower and Fe average concentration was determined higher in prostate cancer tissue, statistically (55.64 µg/kg, p=0.033; 784.02 µg/kg, p<0.001; 656.94 mg/kg, p<0.001 and 56.52 mg/kg, p=0.039, respectively). There was a negative correlation between B and total gleason score (p=0.003) and positive correlation between Se and total gleason score (p=0.002). Mg and Ca were determined higher and B was detected lower in tissues with neuro-vascular invasion (p=0.016, p=0.008 and p=0.033, respectively). Only Zn concentration was lower in cases with extra capsular extention then without (p=0.016). There was no any relationship or correlation between the concentration of trace elements and preoperative PSA levels, biochemical PSA recurrences, surgical margins and invasion of seminal vesicles. The increasing in Fe levels and decreasing in Cd, Ni, Ca, and theirs heterogeneous distribution in malign samples was very important for the investigation of cancer mechanisms. Besides, some of trace elements may effect of the prognosis of prostate cancer. In this context, more studies are needed regarding the increasing or decreasing in the trace element concentrations in malign prostate samples.