Su Bin Park
Gyeongsang National University, Korea
Title: Aruncus dioicus var. kamtschaticus Ameliorates Trimethyltin-induced Neurodegeneration in ICR mice
Biography
Biography: Su Bin Park
Abstract
To estimate physiological effect of ethylacetate fraction of Aruncus dioicus var. kamtschaticus (EFAD) on cognitive dysfunction, in vivo and ex vivo test were conducted in neurodegenerative animal model. The animal model is established as injecting trimethyltin (TMT) (7.1 ðœ‡g/kg of body weight, intraperitoneal injection) in Institute of Cancer Research (ICR) mice. EFAD showed the excellent ameliorating effects on reduced spatial memory ability, short- and long- term memory deficits in the mice through in vivo tests such as the Y-maze, passive avoidance and Morris water maze test. After the behavioral tests, to ascertain the protective effects of EFAD on the cholinergic and antioxidant system, a series of biochemical indicators were measured in brain tissue of mice. Acetylcholine (ACh) as a neurotransmitter and acetylcholinesterase (AChE) as an enzyme that catalyzes the breakdown ACh were measured. EFAD has been proved to have the significant effects on cholinergic system by increasing ACh levles and decreasing AChE activity. In addition, EFAD improve the antioxidant system by diminishing malondialdehyde (MDA), an indicator of lipid peroxide, and elevating antioxidant such as contents of reduced glutathione (GSH) and superoxide dismutase (SOD).