33^rd European Nutrition and Dietetics Conference

Microbiome–Gut–Brain Axis & Metabolic Health

Microbiome–Gut–Brain Axis & Metabolic Health examines how microbial ecosystems influence digestion, immunity, cognition, mood regulation, and systemic metabolic function. The bidirectional communication pathways between the gut microbiota and the central nervous system mediated through microbial metabolites, neurotransmitters, and immune signalling play a significant role in shaping metabolic outcomes. Dysbiosis is now linked to obesity, anxiety, insulin resistance, inflammation, and neurological health challenges. Advanced microbiome sequencing and metabolomics profiling are revealing how dietary patterns affect microbial diversity and metabolic efficiency. Specific prebiotics, probiotics, synbiotics, and postbiotics are being studied for their capacity to restore microbial balance and enhance gut–brain connectivity. Understanding microbial nutritional requirements and their metabolic outputs provides deeper insight into appetite regulation, glucose metabolism, and neurobehavioral responses. This expanding research continues to redefine personalized nutrition and therapeutic diet design, emphasizing the central role of gut ecology in shaping whole-body health.