33^rd European Nutrition and Dietetics Conference

Obesity Science, Energy Balance & Weight-Management Therapies

Obesity Science, Energy Balance & Weight-Management Therapies examines the complex interplay of metabolic, hormonal, genetic, psychological, and behavioral factors that contribute to weight regulation. Modern obesity research recognizes that weight management extends far beyond calorie intake, incorporating metabolic adaptation, gut microbiota composition, insulin sensitivity, circadian rhythms, and neuroendocrine drivers of appetite. Interventions now include personalized dietary plans, pharmacotherapy, metabolic surgery, and digital monitoring tools. Novel therapeutics targeting GLP-1, GIP, and appetite-regulating pathways are transforming obesity treatment frameworks. Behavioral interventions, cognitive restructuring, and mindfulness-based strategies enhance long-term adherence and prevent relapse. Advances in metabolic profiling and adaptive nutrition allow clinicians to tailor interventions that address individual metabolic phenotypes, improving both weight outcomes and overall metabolic health.